       Document 0496
 DOCN  M9620496
 TI    Excess intrauterine fetal demise associated with maternal human
       immunodeficiency virus infection.
 DT    9602
 AU    Langston C; Lewis DE; Hammill HA; Popek EJ; Kozinetz CA; Kline MW;
       Hanson IC; Shearer WT; Department of Pathology, Baylor College of
       Medicine, Houston, TX; 77030, USA.
 SO    J Infect Dis. 1995 Dec;172(6):1451-60. Unique Identifier : AIDSLINE
       MED/96083487
 AB    A prospective study of transplacental transmission of human
       immunodeficiency virus (HIV) showed an increased rate of spontaneous
       fetal demise in HIV-seropositive mothers: 14 losses in 124 pregnancies.
       HIV was detected in placental and fetal tissues in 7 of 14 by in situ
       hybridization. The proportion of fetal infection far exceeded the
       transmission rate of 13% in liveborn babies. No association was seen
       between fetal transmission and a maternal history of drug abuse or
       coinfections; mothers with AIDS more often had fetal loss associated
       with HIV transmission than did asymptomatic mothers. In affected
       fetuses, HIV was detected in many tissues and was associated with thymic
       pathology. This suggests that maternal HIV infection increases the risk
       for pregnancy loss associated with HIV transmission. The possibility
       that HIV may be fetotoxic, that thymic dysfunction may interfere with
       pregnancy progression, or that the intrauterine milieu in
       HIV-seropositive pregnancies may be unfavorable (or a combination of
       factors) should be considered.
 DE    Adolescence  Adult  Child  Disease Transmission, Vertical  Female  Fetal
       Death/*ETIOLOGY  Human  HIV Infections/*COMPLICATIONS  Pregnancy
       *Pregnancy Complications, Infectious  Prospective Studies  Support, U.S.
       Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

