       Document 0489
 DOCN  M9620489
 TI    Coinfection of hepatitis C virus with human immunodeficiency virus and
       progression to AIDS. Italian Seroconversion Study.
 DT    9602
 AU    Dorrucci M; Pezzotti P; Phillips AN; Lepri AC; Rezza G; Laboratorio di
       Epidemiologia e Biostatistica, Istituto Superiore; di Sanita, Rome,
       Italy.
 SO    J Infect Dis. 1995 Dec;172(6):1503-8. Unique Identifier : AIDSLINE
       MED/96083494
 AB    To assess the influence of hepatitis C virus (HCV) on the natural
       history of human immunodeficiency virus (HIV) infection, a longitudinal
       study was conducted among 416 HIV-positive, AIDS-free persons infected
       through injecting drug use or homosexual or heterosexual activity and
       with known seroconversion dates. End points were diagnosis of AIDS and a
       CD4 cell count of < 100 x 10(6) cells/L. HCV antibodies were detected in
       214 persons (51.4%). The crude relative hazard (RH) of progression to
       AIDS was 0.96 (95% confidence interval [CI], 0.53-1.76) for
       HCV-coinfected participants compared with those not coinfected. After
       adjustment for CD4 cell count, the RH was 0.97 (95% CI, 0.52-1.79).
       Similar RHs were found using a CD4 cell count of < 100 x 10(6) cells/L
       as the end point. The median CD4 cell loss was 4.83 x 10(6) cells/L per
       month among coinfected persons and 5.70 x 10(6) cells/L per month among
       the others. These results suggest that coinfection with HCV does not
       influence clinical and immunologic progression of HIV disease.
 DE    Acquired Immunodeficiency Syndrome/*ETIOLOGY  Adolescence  Adult  CD4
       Lymphocyte Count  Female  Hepatitis C/*COMPLICATIONS/IMMUNOLOGY  Human
       HIV Infections/*COMPLICATIONS/IMMUNOLOGY  Longitudinal Studies  Male
       Middle Age  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

