       Document 0487
 DOCN  M9620487
 TI    Interaction with human immunodeficiency virus type 1 modulates innate
       effector functions of human monocytes.
 DT    9602
 AU    Zerlauth G; Maier E; Chehadeh H; Zimmermann K; Eibl MM; Mannhalter JW;
       Immuno AG, University of Vienna, Austria.
 SO    J Infect Dis. 1995 Dec;172(6):1598-601. Unique Identifier : AIDSLINE
       MED/96083510
 AB    The effect of human immunodeficiency virus (HIV) type 1 on human
       mononuclear phagocyte effector functions in response to infection with
       bacteria of the Mycobacterium avium-intracellular complex (MAC) was
       investigated. The results showed that interaction of HIV-1 or its
       constituents with CD4 expressed in the monocyte membrane led to
       substantial impairment of monocyte capacity to restrict the
       intracellular growth of MAC. This was accompanied by substantially
       decreased production of tumor necrosis factor-alpha by HIV-1-exposed and
       MAC-infected monocytes. However, productive HIV-1 infection of monocytes
       was not required to induce the observed effects. These studies suggest
       that HIV-1 may interfere with innate mononuclear phagocyte function.
       This may be of physiologic importance in the late stages of AIDS, when
       an impaired T cell immunity can no longer provide proper
       immune-activating signals, and may help to explain the undue
       susceptibility to MAC infections in these patients.
 DE    Human  HIV-1/*PHYSIOLOGY  Monocytes/*IMMUNOLOGY/VIROLOGY  Mycobacterium
       avium Complex/GROWTH & DEVELOPMENT  Mycobacterium avium-intracellulare
       Infection/ETIOLOGY  Tumor Necrosis Factor/SECRETION  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

