       Document 0469
 DOCN  M9620469
 TI    Extent of T cell receptor ligation can determine the functional
       differentiation of naive CD4+ T cells.
 DT    9602
 AU    Constant S; Pfeiffer C; Woodard A; Pasqualini T; Bottomly K; Section of
       Immunobiology, Yale University School of Medicine, New; Haven,
       Connecticut, USA.
 SO    J Exp Med. 1995 Nov 1;182(5):1591-6. Unique Identifier : AIDSLINE
       MED/96042157
 AB    Naive CD4+ T cells can differentiate into cells predominantly involved
       in humoral immunity, known as T helper type 2 cells (Th2), or cells
       involved in cell-mediated immunity, known as Th1 cells. In this report,
       we show that priming of CD4+ T cells bearing a transgene-encoded T cell
       receptor can lead to differentiation into Th1-like cells producing
       abundant interferon gamma when the cells are exposed to high antigen
       doses, while low doses of the same peptide induce cells with the same T
       cell receptor to differentiate into Th2-like cells producing abundant
       interleukin 4. Thus antigen dose is one factor that can control the
       differentiation fate of a naive CD4+ T cell.
 DE    Animal  Antigens/*IMMUNOLOGY  Cell Differentiation  Cytochrome
       c/IMMUNOLOGY  CD4-Positive T-Lymphocytes/CYTOLOGY/*IMMUNOLOGY
       Dose-Response Relationship, Immunologic  Female  Interferon Type
       II/BIOSYNTHESIS  Interleukin-4/BIOSYNTHESIS  Male  Mice  Mice,
       Transgenic  Moths  Peptide Fragments/CHEMICAL SYNTHESIS/IMMUNOLOGY
       Receptors, Antigen, T-Cell/CHEMISTRY/*IMMUNOLOGY  Support, U.S. Gov't,
       P.H.S.  Th1 Cells/CYTOLOGY/IMMUNOLOGY  Th2 Cells/CYTOLOGY/IMMUNOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

