       Document 0458
 DOCN  M9620458
 TI    Incidence of human immunodeficiency virus-related and nonrelated
       malignancies in a large cohort of homosexual men.
 DT    9602
 AU    Lyter DW; Bryant J; Thackeray R; Rinaldo CR; Kingsley LA; Department of
       Medicine, Graduate School of Public Health,; University of Pittsburgh,
       PA, USA.
 SO    J Clin Oncol. 1995 Oct;13(10):2540-6. Unique Identifier : AIDSLINE
       MED/96007578
 AB    PURPOSE: To determine if the rates of malignancies other than Kaposi's
       sarcoma (KS) and non-Hodgkin's lymphoma (NHL) are increased in human
       immunodeficiency virus (HIV)-infected homosexual men. SUBJECTS AND
       METHODS: From 1984 through 1993, 1,199 homosexual men were studied in
       the Pittsburgh component of the Multicenter AIDS Cohort Study (MACS), an
       examination of the natural history of HIV infection. The cohort
       consisted of 769 HIV-seronegative (SN) participants and 430 seropositive
       (SP) members who were either seroprevalent at the time of enrollment or
       who seroconverted during the study. Cancer incidence data were collected
       through semiannual visits, phone interviews, medical records, and death
       certificates. Five thousand seven hundred eight person-years and 2,344
       person-years were contributed to the study by the SN and SP men,
       respectively. RESULTS: In addition to 44 cases of KS, 13 NHLs, and 3 CNS
       lymphomas (CNSLs), 27 other malignancies occurred (three nonmelanoma
       skin cancers and eight other malignancies in the SP group, eight
       nonmelanoma skin cancers, and eight other malignancies in the SN group).
       Age-adjusted rates were calculated for both groups and compared with
       each other and with rates for the general male population in
       Pennsylvania. There were no differences between the SN group and the
       general population. Among the SP group, the combined frequency of all
       cancers other than KS, NHL, CNSL, and nonmelanoma skin cancers was
       statistically significantly increased in comparison to both the SN group
       and the general population. This increase was secondary to an unusually
       increased frequency of both seminoma and Hodgkin's disease. CONCLUSION:
       These findings support the hypothesis that the incidences of cancers
       other than KS and lymphoma are moderately increased in the setting of
       HIV infection and immunosuppression.
 DE    Adolescence  Adult  Aged  Central Nervous System
       Neoplasms/COMPLICATIONS/EPIDEMIOLOGY  Cohort Studies  Comparative Study
       CD4 Lymphocyte Count  Genital Neoplasms, Male/COMPLICATIONS/EPIDEMIOLOGY
       Hodgkin's Disease/COMPLICATIONS/EPIDEMIOLOGY  Homosexuality,
       Male/*STATISTICS & NUMER DATA  Human  HIV Seronegativity  HIV
       Seropositivity/*COMPLICATIONS/IMMUNOLOGY  Incidence  Lymphoma,
       AIDS-Related/EPIDEMIOLOGY  Male  Middle Age
       Neoplasms/COMPLICATIONS/*EPIDEMIOLOGY  Pennsylvania/EPIDEMIOLOGY
       Sarcoma, Kaposi's/COMPLICATIONS/EPIDEMIOLOGY
       Seminoma/COMPLICATIONS/EPIDEMIOLOGY  Skin
       Neoplasms/COMPLICATIONS/EPIDEMIOLOGY  Support, U.S. Gov't, P.H.S.
       JOURNAL ARTICLE  MULTICENTER STUDY

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

