       Document 0445
 DOCN  M9620445
 TI    [Pathologic anatomy of cytomegalovirus encephalomyelitis and
       varicella-zona virus encephalomyelitis]
 DT    9602
 AU    Henin D; Gervaz E; Seilhean D; Service d'Anatomie et de Cytologie
       Pathologiques, Hopital; Beaujon, Clichy.
 SO    J Neuroradiol. 1995 Sep;22(3):180-3. Unique Identifier : AIDSLINE
       MED/96043313
 AB    Cytomegalovirus (CMV) infection of the nervous system is frequent in
       acquired immunodeficiency syndrome (AIDS) and can be responsible for
       encephalitis, encephalomyelitis, meningoradiculitis or
       polyradiculo-neuropathy. Encephalitis is characterized at microscopy by
       its periventricular and cerebellar location, and by the presence of
       cytomegalic cells, containing intranuclear and/or intracytoplasmic
       inclusions, microglial nodules and necrotic foci. The virus can infect
       almost all types of cells. Coexistence of CMV and HIV has been observed
       in giant cells of macrophagic origin. It has been suggested that the two
       viruses could act in synergy. The nervous system is seldom infected by
       the varicella-zoster virus (VZV) in AIDS. The infection can be
       responsible for multifocal leukoencephalitis, ventriculitis, vascular
       lesions associated or not with cerebral infarction, or with
       meningomyeloradiculitis. In almost all cell types Cowdry's type A
       intranuclear inclusions have been found. The virus can be demonstrated
       by immunohistochemistry or in situ hybridization. VZV antigens have been
       reported in the walls of vessels damaged by a non inflammatory
       obliterating vasculopathy or by a granulomatous angiitis. Coexistence of
       VZV and HIV has been observed in giant cells of macrophagic origin, and
       synergy between those two viruses has been suspected.
 DE    AIDS-Related Opportunistic Infections/*PATHOLOGY  Cerebrovascular
       Disorders/PATHOLOGY/VIROLOGY  Cytomegalovirus Infections/*PATHOLOGY
       Encephalitis, Viral/PATHOLOGY  Encephalomyelitis/*PATHOLOGY/*VIROLOGY
       English Abstract  Herpes Zoster/*PATHOLOGY  Human  Meningitis,
       Viral/PATHOLOGY  Meningoencephalitis/PATHOLOGY/VIROLOGY
       Polyradiculoneuritis/PATHOLOGY/VIROLOGY  Radiculitis/PATHOLOGY/VIROLOGY
       Vasculitis/PATHOLOGY/VIROLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

