       Document 0426
 DOCN  M9620426
 TI    Expression of endogenous HIV-1 crossreactive antigens within normal
       human extravillous trophoblast cells.
 DT    9602
 AU    Lyden TW; Johnson PM; Mwenda JM; Rote NS; Department of
       Microbiology/Immunology, Wright State University; School of Medicine,
       Dayton, Ohio 45435, USA.
 SO    J Reprod Immunol. 1995 Mar;28(3):233-45. Unique Identifier : AIDSLINE
       MED/96070219
 AB    Expression of intact endogenous retroviruses by normal placental villous
       trophoblast and immuno-crossreactivity of villous trophoblast with
       anti-retroviral antisera have been documented. The nature and/or
       potential function of these particles/proteins has not yet been fully
       defined. We previously reported that monoclonal antibodies directed
       against HIV-1 envelope and gag proteins react with normal human villous
       trophoblast. In this study, we report that extravillous trophoblast
       (EVT) from second- and third-trimester tissue are also cross-reactive
       with anti-HIV-1 gp120/160 and p17/18 antibodies. We document a
       differential expression of such cross-reactive epitopes between
       mononuclear EVT and placental bed giant cells. Mononuclear EVT
       principally displayed reactivity throughout the cytoplasm with little or
       no difference between cells, whereas placental bed giant cells displayed
       distinct localization of labeling to limited areas of cytoplasm. This
       pattern of reactivity apparently correlates with trophoblast
       morphological differentiation and with our earlier observations
       concerning villous trophoblast. These data illustrate that
       retrovirus-associated epitopes are expressed by trophoblast throughout
       the normal human placenta and that this distribution is related to
       morphologic differentiation of these cells.
 DE    Chorionic Villi/CHEMISTRY/*IMMUNOLOGY  Cross Reactions  Female  Human
       HIV Antibodies/CHEMISTRY/IMMUNOLOGY  HIV Antigens/CHEMISTRY/*IMMUNOLOGY
       HIV-1/*IMMUNOLOGY  Pregnancy  Support, Non-U.S. Gov't
       Trophoblast/CHEMISTRY/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

