       Document 0419
 DOCN  M9620419
 TI    Candida albicans isolates from HIV-infected and AIDS patients exhibit
       enhanced adherence to epithelial cells.
 DT    9602
 AU    Sweet SP; Cookson S; Challacombe SJ; Department of Oral Medicine and
       Pathology, UMDS Guy's Hospital,; London.
 SO    J Med Microbiol. 1995 Dec;43(6):452-7. Unique Identifier : AIDSLINE
       MED/96080238
 AB    The increased prevalence of oral candidosis associated with HIV
       infection must be intrinsically related to immunological changes in the
       host, but might also involve alterations to the infecting strains of
       yeast. This study aimed to determine if strains of Candida albicans
       isolated from asymptomatic HIV-infected individuals or AIDS patients
       possessed altered adherence properties in an in-vitro buccal epithelial
       cell (BEC) adherence assay. C. albicans isolates from 49 patients with
       HIV infection or AIDS adhered to BEC in significantly higher numbers
       than isolates from 49 control subjects (p < 0.001). No significant
       differences in adherence were detected between strains isolated from
       HIV-infected or AIDS subjects, or between strains isolated from C.
       Albicans carriers (low salivary C. albicans counts) or subjects with
       oral candidosis. The presence of whole saliva significantly inhibited
       the binding of candida to BEC (p < 0.001), but the significant
       difference in adherence between the HIV/AIDS and control isolates was
       maintained. The effect of saliva was independent of salivary candida
       antibodies and was abolished by treatment with protease or
       neuraminidase, suggesting the involvement of salivary mucins. The
       results of this study suggest that HIV infection is associated with the
       selection of strains of C. albicans with and increased ability to adhere
       to oral mucosa.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/MICROBIOLOGY  Adult
       Aged  Candida albicans/IMMUNOLOGY/ISOLATION & PURIF/*PHYSIOLOGY
       Candidiasis, Oral/*MICROBIOLOGY  Cell Adhesion  Cells, Cultured
       Epithelium/CYTOLOGY/METABOLISM/MICROBIOLOGY  Female  Human  HIV
       Infections/*COMPLICATIONS/MICROBIOLOGY  Male  Middle Age  Mouth
       Mucosa/CYTOLOGY/*METABOLISM/MICROBIOLOGY  Saliva/IMMUNOLOGY/MICROBIOLOGY
       Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

