       Document 0376
 DOCN  M9620376
 TI    Regulatory genes of simian immunodeficiency viruses from west African
       green monkeys (Cercopithecus aethiops sabaeus).
 DT    9602
 AU    Jubier-Maurin V; Sarni-Manchado P; Veas F; Vidal N; Bibollet-Ruche F;
       Durand JP; Galat-Luong A; Cuny G; Laboratoire Retrovirus, Institute
       Francais de Recherche; Scientifique pour le Developpment en Cooperation
       (ORSTOM),; Montpellier, France.
 SO    J Virol. 1995 Nov;69(11):7349-53. Unique Identifier : AIDSLINE
       GENBANK/U21093
 AB    The high seroprevalence of simian immunodeficiency viruses (SIVs) in
       African green monkeys (AGMs) without immunological defects in their
       natural hosts has prompted consideration of SIV-infected AGMs as a model
       of apathogenic SIV infection. Study of the molecular mechanisms of
       SIVagm asymptomatic infection could thus provide clues for understanding
       the pathogenesis of human immunodeficiency viruses. Regulatory genes
       could be candidates for genetic control of SIVagm apathogenicity. We
       have characterized Vpr, Tat, Rev, and Nef genes of two SIVagm strains
       isolated from naturally infected sabaeus monkeys captured in Senegal.
       The results provide further evidence that SIVagm from West African green
       monkeys is the most divergent class of AGM viruses, with structural
       features in long terminal repeat sequences and Vpr and Tat genes that
       distinguish them from viruses isolated from other AGM species (vervet,
       grivet, and tantalus monkeys).
 DE    Africa, Western  Amino Acid Sequence  Animal  Cercopithecus
       aethiops/*VIROLOGY  Comparative Study  Exons  Gene Products,
       nef/CHEMISTRY/GENETICS  Gene Products, tat/CHEMISTRY/GENETICS  Gene
       Products, vpr/CHEMISTRY/GENETICS  *Genes, Regulator  *Genes, Viral
       Human  HIV/PATHOGENICITY  Molecular Sequence Data  *Phylogeny  Sequence
       Homology, Amino Acid  Support, Non-U.S. Gov't  SIV/*GENETICS/ISOLATION &
       PURIF/PATHOGENICITY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

