       Document 0262
 DOCN  M9620262
 TI    Zinc and immune function.
 DT    9602
 AU    Ripa S; Ripa R; Istituto di Clinica Medica Generale, Universita di
       Ferrara.
 SO    Minerva Med. 1995 Jul-Aug;86(7-8):315-8. Unique Identifier : AIDSLINE
       MED/96069696
 AB    Zinc and immune function relationship has been extensively studied. Both
       in experimentally induced mineral deficit and in genetically determined
       deficit observable in acrodermatitis enteropathica and in enteropathy of
       Danish A-46 cattle, a B and T dependent antibody response decrease, a T
       dependent cytolytic response decrease and a natural killer cytotoxic
       activity decrease are present noteviously. Serious reduction of the
       immune function is present, in proportion to the value of low zinc
       plasmatic level, in elderly patients, in malnourished and seriously zinc
       deficient children, in patients subjected to total parenteral supply, in
       HIV infections and especially in evident AIDS: in this condition the
       plasmatic zinc level can be considered, together with the CD4+
       lymphocytes amount and the B2-microglobulin value, a disease progression
       marker. Zinc immunostimulating action mechanisms are complex, although
       thymic hormone (of which zinc is essential cofactor) stimulation seems
       to be most important. Zinc supplementation, also parenterally, can be
       useful in immunodeficiency (in the elderly, in the post-surgical
       patients, in genetically determined or alimentary induced deficit, in
       AIDS.
 DE    Acquired Immunodeficiency Syndrome/BLOOD  Age Factors  Aged  Animal
       Autoimmune Diseases/BLOOD/ETIOLOGY  Cattle  Child  Child Nutrition
       Disorders/BLOOD/ETIOLOGY/PREVENTION & CONTROL  Human  *Immunity
       Immunologic Diseases/BLOOD/ETIOLOGY/PREVENTION & CONTROL
       Zinc/ADMINISTRATION & DOSAGE/BLOOD/DEFICIENCY/*PHYSIOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

