       Document 0167
 DOCN  M9620167
 TI    Genomic structure of an attenuated quasi species of HIV-1 from a blood
       transfusion donor and recipients [see comments]
 DT    9602
 AU    Deacon NJ; Tsykin A; Solomon A; Smith K; Ludford-Menting M; Hooker DJ;
       McPhee DA; Greenway AL; Ellett A; Chatfield C; et al; AIDS Molecular
       Biology Unit, Macfarlane Burnet Centre for Medical; Research, Fairfield,
       Victoria, Australia.
 SO    Science. 1995 Nov 10;270(5238):988-91. Unique Identifier : AIDSLINE
       MED/96069819
 CM    Comment in: Science 1995 Nov 10;270(5238):917-8
 AB    A blood donor infected with human immunodeficiency virus-type 1 (HIV-1)
       and a cohort of six blood or blood product recipients infected from this
       donor remain free of HIV-1-related disease with stable and normal CD4
       lymphocyte counts 10 to 14 years after infection. HIV-1 sequences from
       either virus isolates or patient peripheral blood mononuclear cells had
       similar deletions in the nef gene and in the region of overlap of nef
       and the U3 region of the long terminal repeat (LTR). Full-length
       sequencing of one isolate genome and amplification of selected HIV-1
       genome regions from other cohort members revealed no other abnormalities
       of obvious functional significance. These data show that survival after
       HIV infection can be determined by the HIV genome and support the
       importance of nef or the U3 region of the LTR in determining the
       pathogenicity of HIV-1.
 DE    Adult  Aged  Base Composition  Base Sequence  *Blood Donors  Blood
       Transfusion  Cohort Studies  CD4 Lymphocyte Count  Disease Progression
       Female  Gene Rearrangement  *Genes, nef  Genes, Reiterated  Genome,
       Viral  Human  HIV Infections/IMMUNOLOGY/TRANSMISSION/*VIROLOGY  *HIV
       Long Terminal Repeat  HIV-1/*GENETICS/PHYSIOLOGY/*PATHOGENICITY  Male
       Middle Age  Molecular Sequence Data  Sequence Deletion  Support,
       Non-U.S. Gov't  Virulence  Virus Replication  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

