       Document 0132
 DOCN  M9620132
 TI    The relationship between the flamenco gene and gypsy in Drosophila: how
       to tame a retrovirus.
 DT    9602
 AU    Bucheton A; Centre de Genetique Moleculaire, CNRS, Gif-sur-Yvette,
       France.
 SO    Trends Genet. 1995 Sep;11(9):349-53. Unique Identifier : AIDSLINE
       MED/96005621
 AB    For a long time, retroviruses have been considered to be restricted to
       vertebrates. However, the genome of insects contains elements like gypsy
       in Drosophila melanogaster that are strikingly similar to vertebrate
       proviruses of retroviruses, which were considered to be transposable
       elements. Recent results indicate that gypsy has infective properties
       and is therefore a retrovirus, the first to be identified in
       invertebrates. It is normally repressed by a host gene called flamenco,
       which apparently controls the transposition and infective properties of
       gypsy. This provides an exceptional experimental model to investigate
       the genetic relationships between retroviruses and their hosts.
 DE    Alleles  Animal  Drosophila melanogaster/*GENETICS/*VIROLOGY
       DNA-Binding Proteins/GENETICS  Female  Gene Expression Regulation, Viral
       Genes, env  *Genes, Structural, Insect  Invertebrates/VIROLOGY  Male
       Organ Specificity  Ovary/CYTOLOGY/VIROLOGY  Repetitive Sequences,
       Nucleic Acid  *Retrotransposons  Retroviridae/GENETICS/*ISOLATION &
       PURIF/PHYSIOLOGY  Support, Non-U.S. Gov't  Transcription
       Factors/GENETICS/*PHYSIOLOGY  Virus Activation  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

