       Document 0073
 DOCN  M9620073
 TI    Effect of older age on survival in human immunodeficiency virus (HIV)
       disease.
 DT    9602
 AU    Martin JN; Colford JM Jr; Ngo L; Tager IB; Center for AIDS Prevention
       Studies, University of California, San; Francisco, USA.
 SO    Am J Epidemiol. 1995 Dec 1;142(11):1221-30. Unique Identifier : AIDSLINE
       MED/96071717
 AB    To evaluate the impact of older age (> 50 years old) on survival in
       late-stage human immunodeficiency virus (HIV) disease, the authors
       analyzed 846 HIV-infected patients at the San Francisco Veterans Affairs
       Medical Center from 1987 to 1992. The median age was 42 years with 171
       (20.2%) subjects aged 50 or more years. Survival was measured from the
       date of initial lymphocyte testing (median CD4 count, 223 cells/mm3)
       until death or censoring. Compared with those aged less than 40 years,
       and after multivariate proportional hazards adjustment for other
       significant determinants of survival (CD4 percentage, CD8 count,
       hematocrit, and prior acquired immunodeficiency syndrome diagnosis),
       there was no difference in survival for those aged 40-49 years, but
       there was a trend toward decreased survival in those aged 50-59 years
       (relative hazard = 1.32, 95% confidence interval 0.90-1.94) and in those
       aged 60 or more years (relative hazard = 1.56, 95% confidence interval
       0.99-2.46). The impact of older age on mortality in HIV disease is,
       however, less than the impact of age on overall mortality in the United
       States. Accordingly, while older HIV-infected patients do have a
       somewhat poorer survival, this risk need not be too highly emphasized in
       individual patients; older patients deserve aggressive management.
 DE    Adult  Age Factors  Aged  Cohort Studies  CD4 Lymphocyte Count  Human
       HIV Infections/IMMUNOLOGY/*MORTALITY  Middle Age  Mortality
       Multivariate Analysis  Proportional Hazards Models  Support, Non-U.S.
       Gov't  Support, U.S. Gov't, P.H.S.  Survival Analysis  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

