       Document 0040
 DOCN  M9620040
 TI    Increased genital shedding of herpes simplex virus type 2 in
       HIV-seropositive women.
 DT    9602
 AU    Augenbraun M; Feldman J; Chirgwin K; Zenilman J; Clarke L; DeHovitz J;
       Landesman S; Minkoff H; State University of New York-Health Science
       Center at Brooklyn,; USA.
 SO    Ann Intern Med. 1995 Dec 1;123(11):845-7. Unique Identifier : AIDSLINE
       MED/96061864
 AB    OBJECTIVE: To compare the prevalence of genital herpes simplex virus
       type 2 (HSV-2) shedding in human immunodeficiency virus
       (HIV)-seropositive women and HIV-seronegative women. DESIGN:
       Cross-sectional study. SETTING: A major inner-city medical center.
       PATIENTS: 106 women who were HIV-seropositive and HSV-2-seropositive and
       70 women who were HIV-seronegative and HSV-2-seropositive were enrolled
       from various primary care settings. MEASUREMENTS: Herpes simplex virus
       type 2 antibody determinations were done for all patients. Regardless of
       symptoms, vulvar and cervical HSV cultures were obtained from all
       HIV-seropositive women and from a randomly selected subgroup of
       HIV-seronegative women. RESULTS: The prevalence of HSV-2 shedding was
       nearly four times greater in HIV-seropositive than in HIV-seronegative
       women (13.2% compared with 3.6%; P = 0.04; odds ratio, 4.1 [95% CI, 1.0
       to 27.4]) when the serum antibody for HSV-2 was present. Seventy-nine
       percent of viral shedding among HIV-seropositive women was asymptomatic.
       Overall viral shedding increased significantly as the CD4 cell count
       decreased. CONCLUSIONS: Women with HIV infection, particularly those
       with low CD4 cell counts, shed HSV-2 from the vulva and cervix more
       commonly than women not infected with HIV. Most of this shedding is
       asymptomatic.
 DE    Cross-Sectional Studies  CD4 Lymphocyte Count  Female  Herpes
       Genitalis/COMPLICATIONS/TRANSMISSION/*VIROLOGY  Herpesvirus 2,
       Human/*PHYSIOLOGY  Human  HIV Seropositivity/*COMPLICATIONS/IMMUNOLOGY
       Risk Factors  Support, U.S. Gov't, P.H.S.  *Virus Shedding  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

