       Document 0017
 DOCN  M9620017
 TI    Cytotoxic T lymphocyte response to herpes simplex virus type 1 is
       composed of both CD8+ and CD4+ T cell phenotypes in acute and memory
       states.
 DT    9602
 AU    Niemialtowski MG; Rouse BT; Department of Microbiology, University of
       Tennessee, Knoxville; 37996-0845, USA.
 SO    Arch Immunol Ther Exp (Warsz). 1994;42(4):319-24. Unique Identifier :
       AIDSLINE MED/96082650
 AB    Mice were infected via the cornea with HSV-1. Next, draining lymph nodes
       (DLN) and spleen cells were analyzed at various times post infection for
       the presence of cytotoxic T lymphocyte precursors (CTL-p) of both the
       CD8+ and CD4+ phenotypes. Responses were greatest in the DLN, but memory
       CTL persisted in the spleen and were undetectable in DLN by 60 days. On
       all occasions, the frequency of CD8+ CTL outnumbered CD4+ CTL. The
       murine CTL responses to HSV-1 differ from those in man where CD4+ MHC
       class II restricted CTL appear to dominate the response at least in the
       memory phase.
 DE    Acute Disease  Animal  Comparative Study  CD4-Positive
       T-Lymphocytes/*IMMUNOLOGY  CD8-Positive T-Lymphocytes/*IMMUNOLOGY
       Female  Human  *Immunologic Memory  Immunophenotyping  Keratitis,
       Herpetic/*IMMUNOLOGY/PATHOLOGY  Lymph Nodes/IMMUNOLOGY/PATHOLOGY  Male
       Mice  Mice, Inbred BALB C  Organ Specificity  Simplexvirus/*IMMUNOLOGY
       Species Specificity  Spleen/IMMUNOLOGY/PATHOLOGY  T-Lymphocytes,
       Cytotoxic/*IMMUNOLOGY  Virus Latency/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

