       Document 0015
 DOCN  M9620015
 TI    HTLV-I associated myelopathy in patients from Brazil and Iran:
       neurological manifestations and cerebrospinal fluid findings.
 DT    9602
 AU    Puccioni-Sohler M; Kitze B; Felgenhauer K; Klinik und Poliklinik fur
       Neurologie, Georg-August-Universitat,; Gottingen, Germany.
 SO    Arq Neuropsiquiatr. 1995 Jun;53(2):213-7. Unique Identifier : AIDSLINE
       MED/96083350
 AB    We analysed sera and cerebrospinal fluid (CSF) of 20 cases of human
       T-cell lymphotropic virus type (HTLV-I) associated myelopathy/tropical
       spastic paraparesis (HAM/TSP) from Brazil and Iran and as controls, 16
       Brazilian HTLVI seronegative individuals afflicted with other
       neurological diseases. It was observed in the HAM/TSP patients that: 1)
       all had an inflammatory reaction within the central nervous system
       (CNS); 2) 95% (19/20) showed oligoclonal bands reflecting intrathecal
       IgG synthesis; 3) 85% (17/20) presented a local synthesis of HTLVI
       antibodies; 4) 35% (7/20) had a measurable immunoglobulin (Ig) synthesis
       within the CNS. The CSF parameters of the HAM/TSP were compared with the
       clinical data (age at onset, duration of disease and disability level).
       Our data prove that CSF analysis is important for the diagnosis of
       HAM/TSP. There is no association between the severity of the disease and
       CSF findings.
 DE    Adult  Aged  Brazil  Comparative Study  Female  Human  HTLV-I
       Antibodies/*CEREBROSPINAL FLUID  IgG/CEREBROSPINAL FLUID  Iran  Male
       Middle Age  Paraparesis, Tropical Spastic/*CEREBROSPINAL FLUID  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

