       Document 0257
 DOCN  M9620257
 TI    The effects of human immunodeficiency virus infection on macrophage
       phagocytosis of Candida.
 DT    9602
 AU    Eversole LR; Fleischmann J; Baldwin GC; Sapp JP; Section of Diagnostic
       Sciences, University of California at Los; Angeles, School of Dentistry
       90024, United States.
 SO    Oral Microbiol Immunol. 1994 Feb;9(1):55-9. Unique Identifier : AIDSLINE
       MED/96073171
 AB    The effects of infection by human immunodeficiency virus (HIV) on
       phagocytic function towards Candida pseudotropicalis were tested using
       monocytotropic and nonmonocytotropic HIV strains on peripheral blood
       monocytes. There were no differences in either quantitative phagocytic
       activity or efficacy between the two infected and control mock-infected
       monocytes. Immunofluorescence for cytoplasmic p24 antigen and in situ
       hybridization for detection of HIV-specific RNA sequences revealed that
       very few cells (10(-4)) exhibit productive infection. Occasional cells
       with active infection as defined by microscopically detectable
       fluorescence labelling contained phagocytized yeasts.
 DE    AIDS-Related Opportunistic Infections/IMMUNOLOGY
       Candida/*IMMUNOLOGY/ISOLATION & PURIF
       Candidiasis/COMPLICATIONS/IMMUNOLOGY  Cells, Cultured  Comparative Study
       Human  HIV/*IMMUNOLOGY/ISOLATION & PURIF  HIV
       Infections/COMPLICATIONS/*IMMUNOLOGY
       Macrophages/IMMUNOLOGY/MICROBIOLOGY  Monocytes/IMMUNOLOGY/MICROBIOLOGY
       *Phagocytosis  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

