       Document 0224
 DOCN  M9620224
 TI    Differential effects of histamine on T helper type 2 (TH2) lymphocytes.
 DT    9602
 AU    Khan MM; Department of Pharmaceutical Sciences, School of Pharmacy &;
       Allied Health Professions, Creighton University Health Sciences; Center,
       Omaha, Nebraska 68178, USA.
 SO    Proc West Pharmacol Soc. 1995;38:79-81. Unique Identifier : AIDSLINE
       MED/96078125
 AB    Histamine inhibits IL-4 secretion from T helper type 2 cells but
       enhances IL-5 secretion from the same cells. Both of these effects are
       mediated by H2 receptors. Not all cyclic AMP-elevating agents affect
       IL-4 and IL-5 secretion. The observations suggest a selective effect of
       histamine on TH2 lymphocytes. Furthermore, Cl- channels may be involved
       in histamine-mediated regulation of cytokine secretion. The data suggest
       that histamine-induced elevation of cyclicAMP may be an important, but
       probably not the sole, mechanism underlying the selective effects of
       histamine on cytokine production.
 DE    Adolescence  Adult  Asthma/METABOLISM  Chloride Channels/DRUG EFFECTS
       Histamine/*PHARMACOLOGY  Human  In Vitro  Interleukin-4/METABOLISM
       Interleukin-5/METABOLISM  Th2 Cells/*DRUG EFFECTS/METABOLISM  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

