       Document 0876
 DOCN  M9620876
 TI    T cell-rich B cell lymphoma bearing Epstein-Barr virus in tumor cells: a
       case of IBL-T-like lesion following Lennert's lesion.
 DT    9602
 AU    Wakatsuki S; Yumoto N; Takagi T; Kurosu K; Sakai C; Tamayama C; Komatsu
       T; Matsuzaki O; Mikata A; Division of Surgical Pathology, Chiba Cancer
       Center Hospital,; Japan.
 SO    Pathol Int. 1995 Jun;45(6):457-62. Unique Identifier : AIDSLINE
       MED/96086452
 AB    A case of T cell-rich B cell lymphoma (TCRBCL) with Epstein-Barr virus
       (EBV) infection in tumor cells is reported. A 50 year old male developed
       right cervical lymph node swelling in July 1988. Initial biopsy in April
       1989 demonstrated many scattered Hodgkinoid atypical cells with
       Lennert's lesion. After partial remission following chemotherapy, the
       lymph nodes enlarged again, and a second biopsy in February 1991 showed
       an IBL-T-like lesion. Only a small number of Hodgkinoid atypical cells
       were still observed. After apparently, complete remission, the lesion
       soon recurred and the patient died in November 1992.
       Immunohistochemically the Hodgkinoid cells were positive for L26, but
       negative for LN2, LN3, UCHL-1, MT1, lysozyme, Ber-H2 and Leu-M1.
       Reactivity for immunoglobulins showed false-positive because of
       polyclonal staining. IgH monoclonality was detected by the polymerase
       chain reaction method in the first biopsied specimen, and by Southern
       blotting in the second biopsied snap-frozen specimen. Monoclonal TCR
       beta rearrangement was not detected. The Hodgkinoid atypical cells were
       positive for EBV-encoding RNA by in situ hybridization, and LMP-1 by
       immunostaining. Occasionally, EBV-bearing immunoblastic, medium sized,
       or small lymphocytic cells were also observed. This case indicates the
       possibility that EBV is related to the pathogenesis of TCRBCL.
 DE    Blotting, Southern  Case Report  *Herpesvirus 4, Human/GENETICS  Human
       Immunoblastic Lymphadenopathy/*PATHOLOGY/VIROLOGY  In Situ Hybridization
       Lymphoma, B-Cell/*PATHOLOGY/VIROLOGY  Male  Middle Age  Polymerase Chain
       Reaction  RNA, Viral/ANALYSIS  Tumor Virus
       Infections/*PATHOLOGY/VIROLOGY  Viral Matrix Proteins/ANALYSIS  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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