       Document 0486
 DOCN  M9620486
 TI    Herpesvirus-like DNA sequences in non-AIDS Kaposi's sarcoma.
 DT    9602
 AU    de Lellis L; Fabris M; Cassai E; Corallini A; Giraldo G; Feo C; Monini
       P; Institute of Microbiology, University of Ferrara, Italy.
 SO    J Infect Dis. 1995 Dec;172(6):1605-7. Unique Identifier : AIDSLINE
       MED/96083512
 AB    The pathogenesis of Kaposi's sarcoma (KS) is suggested to be related to
       an infectious agent transmitted by sexual contact. Recently, DNA
       sequences homologous to gamma herpesviridae have been identified in
       AIDS-associated KS, but no information is available concerning
       non-AIDS-associated KS. Five classic, 12 endemic, and 17 AIDS-associated
       KS skin lesion specimens were analyzed and all were positive for these
       novel DNA sequences. Twenty-four specimens from normal skin were
       negative. These novel sequences were also found in lymph nodes from
       human immunodeficiency virus-positive patients with AIDS or
       lymphadenopathy syndrome but not in peripheral blood mononuclear cells
       from normal subjects. Therefore, the data support the view that a novel
       gamma herpesvirus might be specifically associated with KS
       etiopathogenesis.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS  DNA, Viral/*ANALYSIS
       Herpesviridae/*GENETICS  Human  Polymerase Chain Reaction  Sarcoma,
       Kaposi's/*VIROLOGY  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

