       Document 1044
 DOCN  M9621044
 TI    Beta 2-microglobulin expression of AIDS-related and classical Kaposi's
       sarcoma.
 DT    9602
 AU    Petersen BL; Petersen CL; Jensen A; Thomsen HK; Werdelin O; Braendstrup
       O; Department of Pathology, Glostrup Hospital, Denmark.
 SO    APMIS. 1995 Jul-Aug;103(7-8):553-7. Unique Identifier : AIDSLINE
       MED/96033961
 AB    The expression of beta 2-microglobulin, the invariable light chain of
       HLA class I molecules, of Kaposi's sarcoma from 11 AIDS patients and
       from 11 patients without known immunodeficiency was studied by
       immunohistochemistry using a polyclonal antibody to beta
       2-microglobulin. The staining intensity of spindle cells in these
       lesions was scored in a semiquantitative system. We found that the
       spindle cells of Kaposi's sarcomas from AIDS patients showed
       significantly increased staining intensity for beta 2-microglobulin
       compared to those of Kaposi's sarcomas from non-AIDS patients. The
       results may indicate that Kaposi's sarcomas developing in
       immunocompromised individuals, such as AIDS patients, are not subject to
       immune selection by T cells eliminating HLA class I high-expressing
       tumor cells, while this may be the case in non-AIDS patients.
       Alternatively, the results may be caused by differences in the activity
       of cytokines, which upregulate the expression of HLA class I molecules
       on the cell surface.
 DE    beta 2-Microglobulin/*BIOSYNTHESIS  Acquired Immunodeficiency
       Syndrome/COMPLICATIONS/*METABOLISM/  PATHOLOGY  Adult  Aged  Aged, 80
       and over  Female  Human  Male  Middle Age  Sarcoma,
       Kaposi's/COMPLICATIONS/*METABOLISM/PATHOLOGY  Skin
       Neoplasms/COMPLICATIONS/*METABOLISM/PATHOLOGY  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

