       Document 0766
 DOCN  M9620766
 TI    A role for a new herpes virus (KSHV) in different forms of Kaposi's
       sarcoma.
 DT    9602
 AU    Schalling M; Ekman M; Kaaya EE; Linde A; Biberfeld P; Department of
       Molecular Medicine, Karolinska Institute and; Hospital, Stockholm,
       Sweden.
 SO    Nat Med. 1995 Jul;1(7):705-6. Unique Identifier : AIDSLINE MED/96071537
 AB    Kaposi's sarcoma (KS) is a previously rare, tumour-like lesion of
       controversial biological nature. KS has since the early 1980s become
       frequent in patients with AIDS, particularly in homosexuals. KS is also
       endemic in Central Africa predominantly in otherwise healthy men but
       also in women and children. Recently, evidence for the presence of
       novel, herpes virus DNA sequences in more than 90% of AIDS Kaposi
       lesions (AKS) was presented. This DNA was identified using
       representational difference analysis (RDA) generating short, unique
       sequences with variable homology to several herpes virus, but no intact
       virus was recovered. If these DNA-sequences are also present in other,
       non-HIV-associated forms of Kaposi's sarcoma this would strongly suggest
       a specific, aetiopathological involvement of this putative new herpes
       virus in the pathogenesis of Kaposi's sarcoma, rather than a
       contamination of yet another opportunistic virus in immunosuppressed
       AIDS patients.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS/VIROLOGY  Adult
       Africa/EPIDEMIOLOGY  Child  DNA, Viral/*ISOLATION & PURIF  Female
       Herpesviridae/*ISOLATION & PURIF/*PATHOGENICITY  Herpesviridae
       Infections/COMPLICATIONS/*VIROLOGY  Human  Immunocompromised Host  Male
       Organ Specificity  Polymerase Chain Reaction  Sarcoma,
       Kaposi's/EPIDEMIOLOGY/ETIOLOGY/*VIROLOGY  Sweden/EPIDEMIOLOGY  Tumor
       Virus Infections/COMPLICATIONS/*VIROLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

