       Document 0369
 DOCN  M9620369
 TI    Apoptosis of HIV-infected cells following treatment with Sho-Saiko-to
       and its components.
 DT    9602
 AU    Wu X; Akatsu H; Okada H; Department of Molecular Biology, Nagoya City
       University School of; Medicine.
 SO    Jpn J Med Sci Biol. 1995 Apr;48(2):79-87. Unique Identifier : AIDSLINE
       MED/96022735
 AB    Baicalein and baicalin are components of Sho-saiko-to (SST), a Chinese
       medical drug which is claimed to be therapeutically effective in
       treating HIV-infected patients. Although 20 micrograms/ml of baicalin
       was not cytotoxic to CEM cells, a cultured T cell line, it proved to be
       cytotoxic to HIV-infected CEM cells (CEM-HIV) with a higher
       HIV-releasing capacity and DNA fragmentation was detected within 24 hr
       of incubation. However, after incubation of CEM-HIV with a lower dose of
       baicalin (0.1, 0.3 and 2 micrograms/ml) for 24 and 48 hr, the viable
       cell number increased by about 25% and the p24 release into the medium
       was 25% lower than that of the control. After further incubation in the
       presence of the agent for 6 and 9 days, only cells with a lower
       HIV-releasing capacity survived. Baicalin might selectively induce
       apoptosis of CEM-HIV cells which have a high virus-releasing capacity,
       and stimulate proliferation of CEM-HIV which have a relatively lower
       capacity of HIV-production.
 DE    Apoptosis/*DRUG EFFECTS  Bioflavonoids/*PHARMACOLOGY  Cells, Cultured
       Drugs, Chinese Herbal/*PHARMACOLOGY  Flavones/*PHARMACOLOGY  Human  HIV
       Infections/*PATHOLOGY  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

