       Document 0579
 DOCN  M9620579
 TI    [Kaposi sarcoma in Caucasian women. Clinical, chemical laboratory and
       endocrinologic studies in 8 women with HIV-associated or classical
       Kaposi sarcoma]
 DT    9602
 AU    Schofer H; Roder C; Zentrum der Dermatologie und Venerologie, Abteilung
       II, J. W.; Goethe-Universitat, Frankfurt.
 SO    Hautarzt. 1995 Sep;46(9):632-7. Unique Identifier : AIDSLINE
       MED/96042936
 AB    Classic and HIV-associated Kaposi's sarcoma (KS) are predominantly found
       in male Caucasians. It is unclear why KS is so rare in women. At the
       Department of Dermatology, University of Frankfurt, epidemic KS was
       diagnosed in 299/751 (40%) male and 5/72 (18%) female HIV-infected
       patients. To detect common parameters regarding immunodeficiency,
       hormonal disturbances, abnormalities in clinical course, or sexual
       practices, data of eight women with KS (five HIV+, three HIV-) were
       compared. In HIV+ women KS is more aggressive than in HIV- women and
       more aggressive than in HIV+ men. Early and frequent visceral
       involvement and no preference for the lower extremities are found.
       Compared to HIV- women with KS, HIV+ women are generally younger (mean
       age 38 vs 71 years) and significantly immunodeficient (reduced absolute
       CD4 cell count and CD4/CD8 ratio). All women with KS investigated for
       sexual hormones (7/8) showed abnormalities: 7/7 had low oestrogens, 4/6
       low LH and 3/5 low progesterone. Controls (n = 11, HIV+ without KS)
       showed a clear trend for higher serum levels of sexual hormones, but the
       difference was not significant. Although different reasons for low
       levels of oestrogens (drug abuse, marasmus, menopause) must be
       considered, the lack of oestrogens seems to be a common finding in HIV+
       and HIV- women with KS. There was no correlation between sexual
       practices (anal or oral-faecal contacts) and the manifestation or
       aggressiveness of KS.
 DE    Acquired Immunodeficiency Syndrome/*DIAGNOSIS/TRANSMISSION  Adult  Aged
       Aged, 80 and over  Case Report  *Caucasoid Race  CD4 Lymphocyte Count
       CD4-CD8 Ratio  English Abstract  Female  Human  Male  Middle Age  Risk
       Factors  Sarcoma, Kaposi's/*DIAGNOSIS/ETIOLOGY  Sex Factors  Sex
       Hormones/BLOOD  Skin Neoplasms/*DIAGNOSIS/ETIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

