       Document 0951
 DOCN  M9620951
 TI    Whole body hyperthermia associated with beta-carotene supplementation in
       patients with AIDS.
 DT    9602
 AU    Pontiggia P; Bianchi Santamaria A; Alonso K; Santamaria L; C Golgi
       Institute of General Pathology, Centro Tumori, University; of Pavia,
       Italy.
 SO    Biomed Pharmacother. 1995;49(5):263-5. Unique Identifier : AIDSLINE
       MED/96026495
 AB    The objective of this work was to check possible additive beneficial
       effects of whole body hyperthermia (WBH) associated with beta-carotene
       (BC) supplementation in patients with AIDS. In a pilot study, 10 HIV
       positive patients, (8 with AIDS and 2 with AIDS related complex, ARC),
       after AZT or DDI discontinuation, were first treated with one single
       session of WBH applied with a non-invasive procedure at 42 degrees C
       core temperature for one hour, and subsequently supplemented with BC 120
       mg daily continuously. All patients well tolerated the non-invasive WBH
       as well as the high dose BC supplementation. Apart from one patient who
       died after 4 months, all the others underwent an HIV burden diminution,
       clinical improvement and amelioration of laboratory data, along with an
       subjective improvement of their life quality. With reference to control
       groups, namely (a) only WBH applied with extracorporeal procedure to 31
       AIDS patients, and (b) only BC supplementation at high dosage applied to
       64 ARC patients, the combined physical and BC supplemental treatments
       clearly showed a better and longer lasting response.
 DE    Acquired Immunodeficiency Syndrome/DRUG THERAPY/*THERAPY  Adult
       Antioxidants/THERAPEUTIC USE  AIDS-Related Complex/THERAPY
       Carotene/*THERAPEUTIC USE  Female  *Food, Fortified  Human
       *Hyperthermia, Induced  Male  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

