       Document 0906
 DOCN  M9620906
 TI    HIV-1 soluble antigens induced CD8+ cytotoxic T-cell responses in an
       immunized individual.
 DT    9602
 AU    Achour A; Moukrim Z; Picard O; Bizzini B; Burny A; Zagury D; Universite
       Pierre et Marie Curie, Paris, France.
 SO    Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):395-400. Unique
       Identifier : AIDSLINE MED/96059400
 AB    In an attempt to determine whether immunization of healthy HIV-1
       seronegative individuals with a soluble gp160 candidate vaccine could
       induce an anti-HIV specific immune response, volunteers were immunized
       by two injections of a water-in-oil emulsion containing a mixture of
       gp160 antigen together with selected peptides. Following immunization,
       lymphocytes were collected and stimulated in vitro with autologous
       HIV-1-infected cells. The results showed that immunization with soluble
       HIV-1 envelope was able to generate CD3+ CD8+ CTLs directed to gp160
       antigen. The CTL response was restricted to class I molecule HLA-A2. The
       CTL response was comparable to that elicited by immunization with
       HIV-1-envelope recombinant vaccinia virus.
 DE    Amino Acid Sequence  Antigens, CD3/BIOSYNTHESIS  AIDS
       Vaccines/IMMUNOLOGY  Cell Line, Transformed  Cell Transformation, Viral
       Cytotoxicity Tests, Immunologic  CD4-Positive T-Lymphocytes/IMMUNOLOGY
       Gene Products, env/*IMMUNOLOGY  Human  Lymphocyte Culture Test, Mixed
       Molecular Sequence Data  Peptide Fragments/IMMUNOLOGY  Protein
       Precursors/*IMMUNOLOGY  Support, Non-U.S. Gov't  T-Lymphocytes,
       Cytotoxic/CYTOLOGY/*IMMUNOLOGY  Vaccination  Vaccines,
       Synthetic/ADMINISTRATION & DOSAGE/IMMUNOLOGY  Vaccinia Virus/IMMUNOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

