       Document 0714
 DOCN  M9620714
 TI    Antibodies to human immunodeficiency virus (HIV-1) in autoimmune
       diseases: primary Sjogren's syndrome, systemic lupus erythematosus,
       rheumatoid arthritis and autoimmune thyroid diseases.
 DT    9602
 AU    Coll J; Palazon J; Yazbeck H; Gutierrez J; Aubo C; Benito P; Jagiello P;
       Maldyk H; Marrugat J; Anglada J; et al; Department of Medicine, Hospital
       del Mar, Universidad Autonoma; de Barcelona, Spain.
 SO    Clin Rheumatol. 1995 Jul;14(4):451-7. Unique Identifier : AIDSLINE
       MED/96070334
 AB    The aetiology of autoimmune diseases remains unknown. The relationship
       between virus, and more recently retrovirus, has been suggested with
       this group of diseases. Immunoblotting is a useful method for
       determining the presence of proteins coded by different retrovirus
       genes. Since the prevalence of these types of proteins in patients with
       primary Sjogren's syndrome (SS), systemic lupus erythematosus (SLE),
       rheumatoid arthritis (RA) and autoimmune thyroid diseases has not been
       fully established, the aim of this work was to determine the prevalence
       of antibodies to immunodeficiency human virus type 1 (HIV-1) proteins in
       these diseases and their possible relationship with the presence of
       anti-nuclear, anti-DNA, anti-SSA (Ro) and anti-SSB (La) autoantibodies.
       Antibodies to human immunodeficiency virus (HIV-1) were studied in a
       group of 341 patients with autoimmune diseases (77 SS, 98 SLE, 75 RA, 91
       autoimmune thyroid diseases) and 126 blood donors as a control group. A
       Western blot was used to detect antibodies to HIV-1, and a double
       polymerase chain reaction (PCR) using nested primers in the gag and pol
       gene of HIV-1. Antinuclear antibodies, anti-DNA, anti-SSA (Ro) and
       anti-SSB (La) were determined by enzyme-linked immunosorbent assays. At
       least one band was shown on immunoblotting in 26% of patients with
       autoimmune diseases and 35% of controls. The presence of antibodies to
       p55 or p68 proteins in patients with SS or SLE proved to be the only
       statistically significant difference between the other autoimmune
       diseases studied and the control group. These antibodies were not
       associated with autoantibodies ANA, DNA, SSA (Ro) or SSB (La).(ABSTRACT
       TRUNCATED AT 250 WORDS)
 DE    Adult  Aged  Antibodies, Antinuclear/ANALYSIS  Arthritis,
       Rheumatoid/IMMUNOLOGY  Autoimmune Diseases/*IMMUNOLOGY  Base Sequence
       Blotting, Western  Enzyme-Linked Immunosorbent Assay  Human  HIV
       Antibodies/*ANALYSIS  HIV-1/*IMMUNOLOGY  Lupus Erythematosus,
       Systemic/IMMUNOLOGY  Middle Age  Molecular Sequence Data  Polymerase
       Chain Reaction  Sjogren's Syndrome/IMMUNOLOGY  Support, Non-U.S. Gov't
       Thyroiditis, Autoimmune/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

