       Document 0599
 DOCN  M9620599
 TI    Reduced CD21 (CR2) and CD54 (ICAM-1) expression in MT2 cells with HIV-1
       or HIV-2 strains.
 DT    9602
 AU    Larcher C; Julen N; Prodinger WM; Totsch M; Gurtler L; Dierich MP;
       Institut fur Hygiene, Universitat Innsbruck, Austria.
 SO    Immunol Lett. 1995 May;46(1-2):31-6. Unique Identifier : AIDSLINE
       MED/96078150
 AB    Alterations in the expression of cell-surface receptors have been
       reported in HIV-infected cells for CD4, CD25 (IL-2 receptor), CD2, CD3
       and CD8 and CD26. In the present study we provide evidence that CD21 is
       down-regulated in the human T-lymphoblastoid cell line MT2 after
       infection with HIV-1 and -2 isolates. The same effect was observed with
       ICAM-1 (CD54). CD21 expression was monitored by means of fluorescence
       intensity, its functional ability to bind to C3d and by quantitative
       measurement of CD21-antigen in supernatants and cell lysates using an
       immunoassay. In addition, the decrease of CD21 and ICAM-1-specific mRNA
       suggests a mechanism at a transcriptional level. Our data suggest that
       HIV might have a direct influence on the receptor expression.
 DE    Cell Line, Transformed  Down-Regulation (Physiology)/*IMMUNOLOGY  Human
       HIV-1/*IMMUNOLOGY  HIV-2/*IMMUNOLOGY  Intercellular Adhesion
       Molecule-1/GENETICS/*METABOLISM  Receptors, Complement
       3d/GENETICS/*METABOLISM  RNA, Messenger/ANALYSIS  Support, Non-U.S.
       Gov't  T-Lymphocytes/*IMMUNOLOGY/VIROLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

