       Document 0045
 DOCN  M9620045
 TI    Ethanol as a possible cofactor in the development of murine AIDS.
 DT    9602
 AU    Fitzpatrick EA; Rhoads CA; Espandiari P; Kaplan AM; Cohen DA; Department
       of Microbiology and Immunology, University of; Kentucky, College of
       Medicine, Lexington 40536-0084, USA.
 SO    Alcohol Clin Exp Res. 1995 Aug;19(4):915-22. Unique Identifier :
       AIDSLINE MED/96026606
 AB    Chronic ethanol (EtOH) abuse in humans leads to a variety of
       immunomodulatory events that can alter resistance to a number of
       infectious agents. Whether alcohol abuse affects the susceptibility to
       human immunodeficiency virus infection or the subsequent development of
       acquired immune deficiency syndrome (AIDS) is a matter of extreme
       importance; however, available information in humans or animal models is
       limited. The goal of this study was to evaluate the effect of chronic
       EtOH feeding in mice on the development of immunodeficiency in the
       murine model of AIDS (MAIDS). C57BI/6 mice were placed on the
       Lieber-DeCarli liquid EtOH diet (25% or 31% total caloric intake) or a
       nutrient-matched isocaloric liquid control diet. Seven days later, mice
       were infected with the LP-BM5 murine leukemia virus mixture, and groups
       of infected and noninfected mice were assayed at defined time points
       postinfection for antigen-specific and nonspecific immune responses. In
       the absence of retroviral infection, chronic EtOH feeding (5-8 weeks)
       led to reductions in spleen weights, compared with isocaloric controls.
       In spite of reduced spleen size, mitogenic responses of spleen cells to
       concanavalin A (ConA) and lipopolysaccharide (LPS) were elevated in
       EtOH-fed mice, as compared with mice fed the control diet. Chronic EtOH
       feeding also enhanced the allogeneic mixed lymphocyte response and
       increased antigen-specific priming of both B-cells and CD4+ T-cells to
       the antigen, sheep red blood cells. In MAIDS-infected mice, chronic EtOH
       feeding delayed but did not prevent the onset of virus-induced
       immunodeficiency and MAIDS-induced autoantibody synthesis.(ABSTRACT
       TRUNCATED AT 250 WORDS)
 DE    Alcoholism/*IMMUNOLOGY  Animal  Antibody Formation/IMMUNOLOGY
       Autoantibodies/BLOOD  B-Lymphocytes/IMMUNOLOGY  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  Epitopes/IMMUNOLOGY
       Immunocompetence/IMMUNOLOGY  Liver/IMMUNOLOGY  Lymphocyte
       Transformation/IMMUNOLOGY  Male  Mice  Mice, Inbred C57BL  Murine
       Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Spleen/IMMUNOLOGY
       Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

