       Document 0824
 DOCN  M9620824
 TI    Progress towards gene therapy for HIV infection.
 DT    9602
 AU    Yu M; Poeschla E; Wong-Staal F; Department of Medicine, University of
       California, San Diego, La; Jolla 92093-0665, USA.
 SO    Gene Ther. 1994 Jan;1(1):13-26. Unique Identifier : AIDSLINE
       MED/96050915
 AB    The retroviral life cycle and genetic plasticity of human
       immunodeficiency virus 1 (HIV-1) present unprecedented therapeutic
       challenges. Twelve years into the HIV epidemic, satisfactory treatment
       remains elusive. Our current understanding of AIDS pathogenesis calls
       for early intervention with antiviral agents. Although still in its
       infancy, human gene therapy holds considerable potential for the
       long-term treatment of genetic disorders, cancer and chronic infectious
       diseases. Gene therapy for HIV infection is receiving particularly
       intensive study: approaches that are in development include both
       immunotherapy (e.g. therapeutic vaccines and adoptive transfer of CD8+
       T-cell clones) and direct antiviral therapy (intracellular
       immunization). The latter strategies include transdominant modifications
       of HIV proteins, RNA decoys, antisense RNA, ribozymes and modifications
       of cellular proteins (e.g. intracellular antibodies, soluble CD4).
       Several of these strategies are now entering clinical trials. While
       significant conceptual and technical hurdles remain to be overcome
       before the promise of gene therapy for HIV infection can be fully
       realized, progress in this field is likely to be rapid and to contribute
       to the broader applicability of human gene therapy to the treatment of
       other disorders.
 DE    Clinical Protocols  *Gene Therapy  Gene Transfer  Genetic Vectors
       Hematopoietic Stem Cell Transplantation  Human  HIV
       Infections/GENETICS/*THERAPY/VIROLOGY  *HIV-1/GENETICS  Immunotherapy
       Mutation  Retroviridae Proteins/GENETICS/IMMUNOLOGY  RNA,
       Antisense/GENETICS/THERAPEUTIC USE  RNA, Catalytic/GENETICS  RNA,
       Viral/GENETICS  Support, U.S. Gov't, Non-P.H.S.  Support, U.S. Gov't,
       P.H.S.  JOURNAL ARTICLE  REVIEW  REVIEW, ACADEMIC

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

