       Document 0088
 DOCN  M9620088
 TI    T-lymphocyte subsets in the peripheral blood of patients with renal cell
       carcinoma.
 DT    9602
 AU    Mitropoulos D; Alamanis C; Deliveliotis C; Zervas A; Tzirakis A;
       Dimopoulos C; Department of Urology, Athens Medical School, Greece.
 SO    Acta Urol Belg. 1995 Sep;63(3):21-5. Unique Identifier : AIDSLINE
       MED/96050294
 AB    We analyzed the phenotypic distribution of the major T-lymphocyte
       subsets in the peripheral blood of 22 renal cell carcinoma patients
       before and after nephrectomy. We also compared these distributions to
       those of healthy controls and related them to tumor spread. The
       lymphocyte subsets were analyzed by means of flow cytometry. The CD4+
       subset was the only one which was significantly decreased (x +/- SD:
       36.2 +/- 6.4 vs 41.4 +/- 2.2 in healthy controls, P < 0.05), this
       contributing to a significant decrease in the CD4/CD8 ration (x +/- SD:
       102 +/- 0.56 vs 1.42 +/- 0.28, P < 0.05). The decrease was more apparent
       with advanced stage. Helper cell activity increased significantly after
       nephrectomy in the higher stage patients (x +/- SD: 41.1 +/- 4.6 vs 36.4
       +/-3.1 and 38.2 +/- 3.9 vs 30.1 +/- 4.2 for stage T3 and T4 patients
       respectively). Knowledge of peripheral blood lymphocyte patterns that
       correlate with various tumor stages and therapies could provide
       information in host-tumor relationship and predict the clinical outcome
       and response to therapy.
 DE    Adult  Aged  Carcinoma, Renal Cell/*BLOOD/GENETICS/SURGERY  CD4-CD8
       Ratio  Female  Flow Cytometry  Human  Kidney
       Neoplasms/*BLOOD/GENETICS/SURGERY  Male  Middle Age  Nephrectomy
       Phenotype  Support, Non-U.S. Gov't  T-Lymphocyte Subsets/*CHEMISTRY
       T-Lymphocytes, Helper-Inducer  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

