       Document 0801
 DOCN  M9620801
 TI    HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian
       women.
 DT    9602
 AU    Rowland-Jones S; Sutton J; Ariyoshi K; Dong T; Gotch F; McAdam S; Whitby
       D; Sabally S; Gallimore A; Corrah T; et al; Institute of Molecular
       Medicine, John Radcliffe Hospital,; Headington, Oxford, UK.
 SO    Nat Med. 1995 Jan;1(1):59-64. Unique Identifier : AIDSLINE MED/96071373
 AB    A crucial requirement in the rational design of a prophylactic vaccine
       against the human immunodeficiency virus (HIV) is to establish whether
       or not protective immunity can occur following natural infection. The
       immune response to HIV infection is characterized by very vigorous
       HIV-specific cytotoxic T-lymphocyte (CTL) activity. We have identified
       four HIV-1 and HIV-2 cross-reactive peptide epitopes, presented to CTL
       from HIV-infected Gambians by HLA-B35 (the most common Gambian class I
       HLA molecule). These peptides were used to elicit HIV-specific CTLs from
       three out of six repeatedly exposed but HIV-seronegative female
       prostitutes with HLA-B35. These women remain seronegative with no
       evidence of HIV infection by polymerase chain reaction or viral culture.
       Their CTL activity may represent protective immunity against HIV
       infection.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY  Amino Acid Sequence
       Cytotoxicity, Immunologic  Female  Gambia  Human  HIV Antigens/CHEMISTRY
       HIV-1/*IMMUNOLOGY  HIV-2/IMMUNOLOGY  HLA-B35 Antigen/IMMUNOLOGY
       Immunity, Cellular  Molecular Sequence Data  Peptides/IMMUNOLOGY
       Support, Non-U.S. Gov't  T-Lymphocytes, Cytotoxic/*IMMUNOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

