       Document 0205
 DOCN  M9620205
 TI    [Acute pancreatitis in patients infected with the human immunodeficiency
       virus]
 DT    9602
 AU    Veny A; Romeu J; Raventos A; Lopez MP; Sirera G; Clotet B; Unidad de
       SIDA. Servicio de Medicina Interna, Hospital; Universitario Germans
       Trias i Pujol, Badalona, Barcelona.
 SO    Rev Clin Esp. 1995 Sep;195(9):614-9. Unique Identifier : AIDSLINE
       MED/96079689
 AB    This study was designed to define the etiological spectrum of acute
       pancreatitis in patients infected with HIV in our environment and to
       evaluate the relevance of cytomegalovirus as etiological agent. A
       retrospective analysis was first made of clinical, analytical,
       radiological and pathological findings of patients infected with HIV
       clinically diagnosed of acute pancreatitis (period 1984-1993). Then,
       clinical records of patients with necropsy proven CMV pancreatic
       involvement were retrospectively analyzed (period 1985-1992) to evaluate
       whether they had been diagnosed of acute pancreatitis when alive. Nine
       cases were diagnosed of acute pancreatitis. A presumptive etiology
       (didanosine) was considered in seven cases and idiopathic in two. Five
       patients died, two from causes directly related to acute pancreatitis.
       Necropsy was performed in two cases. Mortality was associated with the
       development of renal insufficiency or the appearance of three or more
       complications (p = 0.039). With regard to the second phase of the study
       CMV pancreatic involvement was demonstrated in 4 necropsies out of a
       total of 22 with evidence of CMV infection in one or more organs. None
       of these patients was diagnosed of acute pancreatitis when alive. Acute
       pancreatitis is an uncommon entity in patients infected with HIV.
       Presumptively, it could be attributed to didanosine therapy in most of
       our cases. The mortality rate was high, particularly when renal failure
       developed. In no case was CMV involved as etiologic agent when the
       patient was alive, although necropsy showed that pancreas can be
       subclinically involved in the context of a CMV disseminated infection.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/MORTALITY/  PATHOLOGY
       Acute Disease  Adult  Autopsy  AIDS-Related Opportunistic
       Infections/COMPLICATIONS/DIAGNOSIS/  MORTALITY/PATHOLOGY
       Cytomegalovirus Infections/COMPLICATIONS/DIAGNOSIS/MORTALITY/  PATHOLOGY
       English Abstract  Female  Human  HIV
       Infections/*COMPLICATIONS/MORTALITY/PATHOLOGY  *HIV-1  Male  Middle Age
       Pancreatitis/*DIAGNOSIS/ETIOLOGY/MORTALITY/PATHOLOGY  Prognosis
       Retrospective Studies  Spain/EPIDEMIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

