       Document 0367
 DOCN  M9620367
 TI    A novel adult T cell leukemia-derived cell line (SALT-3) susceptible to
       human immunodeficiency virus type 1 infection.
 DT    9602
 AU    Sagawa K; Koga T; Sasaguri Y; Sadamori N; Nagai K; Department of
       Immunology, Kurume University School of Medicine,; Japan.
 SO    Kurume Med J. 1995;42(3):149-60. Unique Identifier : AIDSLINE
       MED/96054650
 AB    A novel human T cell line (SALT-3) was established from the pleural
       effusion of a patient with adult T cell leukemia (ATL) of lymphoma type.
       SALT-3 showed atypical T cell markers such as
       CD1-CD2-CD3-CD4+CD5+CD7+CD8-CD19-CD20-CD25+HLA-DR+. T cell receptor
       alpha/beta and gamma/delta were undetectable. Human T cell lymphotropic
       virus type 1 (HTLV-I) particles were seen on SALT-3 cells by electron
       microscopic analysis. HTLV-I gag p19, proviral DNA and mRNA of HTLV-I
       genes were also detected in the cells. Chromosome analysis showed
       abnormal karyotypes as 47, XY, partial trisomy of No.3 chromosome, and
       trisomy of No. 7 chromosome. Furthermore, SALT-3 were susceptible to the
       infection of human immunodeficiency virus type 1 (HIV-1) and the cells
       were rapidly killed after HIV-1 infection. This newly established
       HTLV-I-infected human T cell line would be a useful tool to study
       biological activities of atypical type of ATL cells and to examine the
       cytotoxic effects of HIV-1 and it's modulators.
 DE    Aged  Case Report  Cell Line  Human  *HIV Infections  Leukemia-Lymphoma,
       T-Cell, Acute, HTLV-I-Associated/GENETICS/  *MICROBIOLOGY/*PATHOLOGY
       Male  Support, Non-U.S. Gov't  Tumor Cells, Cultured  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

