       Document 0293
 DOCN  M9620293
 TI    [Neurological manifestations in HIV-infected child]
 DT    9602
 AU    Bossi G; Maccabruni A; Caselli D; Astori MG; Piazza F; Clinica
       Pediatrica, Policlinico San Matteo IRCCS, Pavia.
 SO    Minerva Pediatr. 1995 Jul-Aug;47(7-8):285-95. Unique Identifier :
       AIDSLINE MED/96019690
 AB    The authors describe the main epidemiological, pathogenetic and clinical
       features of HIV-related encephalopathy in 50 pediatric patients (36
       females, 24 males), born to HIV-seropositive mothers or infected by
       contaminated blood, observed in the Institute of Infectious Diseases of
       Pavia, between January 1984 and December 1994. All the patients (age 1
       day-7 years) received a comprehensive evaluation, including subsequent
       neurodevelopmental assessments, by a multidisciplinary equipe of
       pediatric infectivologists and neuro-psychiatrists: the follow-up ranges
       from 6 months to 8.5 years. To evaluate the role of potentially
       covariates in HIV-vertically infected children, some maternal,
       gestational and perinatal factors were investigated. The
       neurodevelopmental assessment was carried out by a standardized
       protocol: tests were always conducted and evaluated by the same
       examiner. Seventeen pediatric patients with HIV-related neurologic
       impairment were observed (34%): 16 cases of encephalopathy
       (static-stable = 4, plateau = 6, subacute-progressive = 5, uncertain
       origin = 1) and 1 case of neurotoxoplasmosis. Findings of the current
       study demonstrate the high frequency of neurological impairment in
       HIV-infected infant/child, a worse evolution in this kind of patients
       and the effectiveness of an antiretroviral therapy only if administrated
       in the early phases of the disease. It was also emphasized the
       pathogenetic role of some covariates poorly evaluated in previously
       reported studies.
 DE    AIDS Dementia Complex/DIAGNOSIS/*PHYSIOPATHOLOGY
       Brain/*PHYSIOPATHOLOGY/RADIOGRAPHY  Case Report  Child  Child, Preschool
       Comparative Study  English Abstract  Female  Human  HIV
       Seropositivity/*PHYSIOPATHOLOGY  Infant  Male  Tomography, X-Ray
       Computed  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

