       Document 0948
 DOCN  M9620948
 TI    Factors associated with extrapulmonary tuberculosis as an AIDS-defining
       disease in Europe. The Coordinators of AIDS surveillance in Austria,
       Belgium, France, Germany, Italy, Portugal, Switzerland, United Kingdom
       and the city of Amsterdam.
 DT    9602
 AU    Schwoebel V; Delmas MC; Ancelle-Park RA; Brunet JB; European Centre for
       the Epidemiological Monitoring of AIDS,; Saint-Maurice, France.
 SO    Tuber Lung Dis. 1995 Aug;76(4):281-5. Unique Identifier : AIDSLINE
       MED/96048189
 AB    SETTING: Western Europe: 8 countries and the city of Amsterdam.
       OBJECTIVE: To identify factors associated with extrapulmonary
       tuberculosis (EPTB) at AIDS diagnosis among adult AIDS patients. DESIGN:
       The proportion of AIDS case diagnosed between January 1988 and June 1992
       with EPTB was analysed by age, gender, year of diagnosis, country and
       HIV transmission category. Multiple logistic regression was performed
       separately for patients infected through heterosexual contact who were
       likely to originate from Africa or the Caribbean (heterosexual subgroup
       1), and for other patients. RESULTS: The overall proportion with EPTB
       was 4.6% and remained stable between 1988 and 1992. It differed
       significantly by country (from 2.4% in the United Kingdom to 24.7% in
       Portugal) and by transmission category (2.7% among homo/bisexuals, 5.8%
       among injecting drug users, 13.6% among heterosexual subgroup 1). In
       multivariate analysis, the risk of EPTB was independently associated
       with younger age and male gender. Among patients other than from
       heterosexual subgroup 1, country and transmission category were also
       independent predictors of EPTB at AIDS diagnosis. CONCLUSION: The risk
       of presenting EPTB as an AIDS-defining disease is not homogeneous within
       Europe. Results suggest an increased risk of tuberculosis in specific
       groups of HIV-infected persons (persons originating from sub-Saharan
       Africa, injecting drug users) and a potential role of recent
       Mycobacterium tuberculosis infection among younger patients.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adolescence  Adult
       Age Factors  Aged  AIDS-Related Opportunistic
       Infections/*COMPLICATIONS/EPIDEMIOLOGY  Europe/EPIDEMIOLOGY  Female
       Human  HIV Infections/TRANSMISSION  Male  Middle Age  Risk Factors  Sex
       Factors  Support, Non-U.S. Gov't
       Tuberculosis/*COMPLICATIONS/EPIDEMIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

