       Document 0732
 DOCN  M9620732
 TI    Accumulation of activated CD4+ lymphocytes in the lung of individuals
       infected with HIV accompanied by increased virus production in patients
       with secondary infections.
 DT    9602
 AU    Franchini M; Walker C; Henrard DR; Suter-Gut D; Braun P; Villiger B;
       Suter M; Swiss Institute of Allergy and Asthma Research (SIAF), Davos;
       Platz, Switzerland.
 SO    Clin Exp Immunol. 1995 Nov;102(2):231-7. Unique Identifier : AIDSLINE
       MED/96069868
 AB    The lung is continuously exposed to infectious and non-infectious agents
       causing cell activation. Activated cells in the lung such as
       antigen-presenting cells which harbour HIV may favour this organ as a
       site for virus production. To test this hypothesis, cells from blood and
       bronchoalveolar lavage (BAL) of HIV-infected patients and healthy
       controls were obtained and the activation of the cells were analysed by
       measuring the expression of IL-2 receptor, HLA-DR and VLA-1. The
       HIV-infected individuals were subdivided into 'lung symptomatic' or
       'lung asymptomatic' patients, depending on the presence or absence of
       secondary lung diseases besides HIV. All HIV-infected individuals
       demonstrated a decreased number of CD4+ lymphocytes in blood; however,
       normal numbers of these cells were found in BAL. The activation state of
       CD4+ and CD8+ T lymphocytes in blood and BAL was higher in lymphocytes
       from HIV-infected patients compared with controls. The activation state
       was highest in the lung symptomatic group. Lung symptomatic patients and
       lung asymptomatic patients with extrapulmonary infections had increased
       levels of free virus in plasma. Four out of four individuals without or
       with only low amounts of cell-free HIV in plasma belonged to the
       symptom-free subgroup. These results suggest that microorganisms other
       than HIV may promote viral replication via antigen-driven accumulation
       and activation of CD4+ cells in the lung or other organs, and thus may
       be responsible for the loss of helper T cells and the progression of the
       disease.
 DE    Bronchoalveolar Lavage Fluid/CYTOLOGY  CD4-Positive
       T-Lymphocytes/*IMMUNOLOGY  Female  Human  HIV
       Infections/COMPLICATIONS/*IMMUNOLOGY  HIV-1/GROWTH & DEVELOPMENT  Lung
       Diseases/COMPLICATIONS/*IMMUNOLOGY  Male  Support, Non-U.S. Gov't
       *Virus Replication  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

