       Document 0491
 DOCN  M9620491
 TI    Incidence and predictors of human immunodeficiency virus type 1
       seroconversion in patients attending sexually transmitted disease
       clinics in India.
 DT    9602
 AU    Mehendale SM; Rodrigues JJ; Brookmeyer RS; Gangakhedkar RR; Divekar AD;
       Gokhale MR; Risbud AR; Paranjape RS; Shepherd ME; Rompalo AE; et al;
       National AIDS Research Institute, B. J. Medical College, Pune,; India.
 SO    J Infect Dis. 1995 Dec;172(6):1486-91. Unique Identifier : AIDSLINE
       MED/96083492
 AB    The first estimates of the seroincidence of human immunodeficiency virus
       type 1 (HIV-1) and of the risk factors for seroconversion in a cohort of
       high-risk patients attending sexually transmitted disease (STD) clinics
       in India are reported. Between 1993 and 1995, 851 HIV-1-seronegative
       persons were evaluated prospectively every 3 months for HIV infection
       and biologic and behavioral characteristics. The overall incidence of
       HIV-1 was 10.2/100 person-years (95% confidence interval, 7.9-13.1). The
       incidence among commercial sex workers (CSWs) was 26.1/100 person-years,
       compared with 8.4 among non-CSWs. Recurrent genital ulcer disease and
       urethritis or cervicitis during the follow-up period were independently
       associated with a 7- (P < .001) and 3-fold (P = .06) increased risk of
       HIV-1 seroconversion, respectively. Because of the association of
       recurrent ulcerative and nonulcerative STDs with HIV-1 seroconversion in
       this setting, behavioral and biologic measures directed at the
       prevention and control of STDs would be expected to greatly reduce the
       transmission of HIV-1 infection in similar high-risk groups.
 DE    Adult  Aged  Female  Human  HIV Seropositivity/*EPIDEMIOLOGY
       HIV-1/*IMMUNOLOGY  Incidence  India/EPIDEMIOLOGY  Male  Middle Age  Risk
       Factors  Sexually Transmitted Diseases/COMPLICATIONS  Support, U.S.
       Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

