       Document 0910
 DOCN  M9620910
 TI    Internal transcriptional regulatory elements in HIV-1 and other
       retroviruses.
 DT    9602
 AU    Verdin E; Van Lint C; Picower Institute for Medical Research, Laboratory
       of Molecular; Virology, Manhasset, NY 11030, USA.
 SO    Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):365-9. Unique Identifier
       : AIDSLINE MED/96059396
 AB    The transcriptional regulation of retroviruses plays an important role
       in their pathogenesis. Cis-acting elements have been identified in the
       long terminal repeat (LTR) at the 5' extremity of the integrated
       provirus. These elements determine the rate and the site of
       transcription initiation and consist of arrays of binding sites for
       transcription factors. Recent studies have demonstrated the presence of
       additional regulatory elements, located outside of the LTR, within the
       transcribed region of several retroviruses including avian and murine
       retroviruses, HIV-1, HTLV-1 and the human spumaretroviruses. This review
       describes these new observations and analyzes their significance both in
       terms of retroviral transcriptional regulation and in terms of
       pathogenesis.
 DE    Animal  *Gene Expression Regulation, Viral  *Genes, Regulator  Genome,
       Viral  Human  HIV-1/*GENETICS/PATHOGENICITY  HTLV-I/GENETICS  Leukemia
       Virus, Bovine/GENETICS  Leukemia Viruses, Murine/GENETICS  Mice
       Promoter Regions (Genetics)  Repetitive Sequences, Nucleic Acid
       Retroviridae/*GENETICS/PATHOGENICITY  Retroviruses, ALV-Related/GENETICS
       Spumavirus/GENETICS  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

