       Document 1058
 DOCN  M9621058
 TI    HIV status of female sex partners of men reactive to HIV-1, HIV-2 or
       both viruses in Abidjan, Cote d'Ivoire.
 DT    9602
 AU    N'Gbichi JM; De Cock KM; Batter V; Yeboue K; Ackah A; Zadi F; Diallo MO;
       Kadio A; Gayle HD; Projet RETRO-CI, Abidjan, Cote d'Ivoire.
 SO    AIDS. 1995 Aug;9(8):951-4. Unique Identifier : AIDSLINE MED/96014971
 AB    OBJECTIVES: To compare rates of serologic concordance in the female sex
       partners of men with HIV-1 and HIV-2 infections, and to determine the
       serologic status of sex partners of men who reacted serologically to
       both viruses. DESIGN: Cross-sectional study. SETTING: Infectious
       diseases service in a University Hospital in Abidjan, Cote d'Ivoire
       (West Africa). PARTICIPANTS: Hospitalized men reactive on synthetic
       peptide-based tests to HIV-1, HIV-2 or both viruses (dually reactive),
       and their spouses visiting them in hospital. OUTCOME MEASURES: Serologic
       status of female spouses of seropositive men. RESULTS: The serologic
       status of 540 spouses of 490 HIV-1- and/or HIV-2-positive, hospitalized
       men was studied. Similar proportions of spouses of HIV-1-infected men
       (49%) and HIV-2-infected men (44%) were concordantly seropositive. The
       overall prevalence of infection in spouses of dually reactive men (72%)
       was significantly higher than in spouses of other men; 44% of these
       spouses were infected with HIV-1, 8% with HIV-2, and 20% were themselves
       dually reactive. Considering only the seropositive female spouses of men
       monotypically reactive to HIV-1 or HIV-2, and the male spouses of women
       monotypically infected, rates of serologic discordance were
       significantly greater in men (24%) than women (7%). CONCLUSIONS: Men
       were likely to have been infected earlier than women because of their
       HIV-associated illness; also, men more frequently had serologic profiles
       indicative of infection outside of the union. Rates of serologic
       concordance in spouses of men with advanced HIV-1 or HIV-2 infection
       were similar (44-49%). Dually reactive hospitalized men frequently (72%)
       had seropositive sex partners, most of whom were HIV-1-positive. Dual
       reactivity was also frequent in these spouses, suggesting transmission
       of both HIV-1 and HIV-2, or of a cross-reactive strain, and a minority
       of partners were infected with HIV-2 alone. Prospective studies of
       discordant couples using quantitative molecular diagnostic techniques
       are required for better understanding of dual reactivity and
       transmission of HIV-1 and HIV-2.
 DE    Adolescence  Adult  Aged  Cote d'Ivoire/EPIDEMIOLOGY  Cross-Sectional
       Studies  Female  Human  HIV Infections/*EPIDEMIOLOGY/*TRANSMISSION  *HIV
       Seroprevalence  *HIV-1  *HIV-2  Male  Middle Age  Sex Behavior  *Sexual
       Partners  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

