       Document 0555
 DOCN  M9620555
 TI    Characteristics of the T lymphocytes involved in experimental allergic
       encephalomyelitis.
 DT    9602
 AU    Kalman B; Alder H; Lublin FD; Thomas Jefferson University, Department of
       Neurology,; Philadelphia, PA 19107, USA.
 SO    J Neuroimmunol. 1995 Sep;61(2):107-16. Unique Identifier : AIDSLINE
       MED/96049070
 AB    Both heterogeneity and restricted heterogeneity of the encephalitogenic
       myelin basic protein (MBP) peptide-specific T cell receptors (TCRs) were
       demonstrated in inbred animals depending on the strain-specific genetic
       characteristics, the stage of the disease, the compartment of the
       lymphocytes obtained and the methodology used. Nevertheless, the similar
       features of some MBP-specific TCRs demonstrated across species suggest
       that conservation of these autoantigen-specific molecules undoubtedly
       exists, even though the degree of this conservation is controversial.
       However, the unequivocal heterogeneity of the immune response directed
       at one of the most important myelin constituents, proteolipid
       lipoprotein (PLP), which occurs either as a primary or a secondary event
       during experimental allergic encephalomyelitis (EAE), indicates the
       complexity of the in vivo situation. Intramolecular and intermolecular
       spreading of antigen specificity during the course of the disease
       indicates that a TCR directed therapy may not be the choice of
       intervention in established disease even in individual strains of
       laboratory animals with restricted heterogeneity of the primary
       MBP-specific response. Studying the sequence of events, the recruited
       regulatory cells and cytokines, and the stromal factors controlling
       persistence or death of activated, memory cells in the tissue lesion,
       may reveal new therapeutic modalities with more universal
       applicabilities.
 DE    Animal  Antigens, CD45/IMMUNOLOGY  Chronic Disease  Clone Cells
       Encephalomyelitis, Allergic/*IMMUNOLOGY  Integrins/IMMUNOLOGY  Mice
       Myelin Basic Proteins/IMMUNOLOGY  Myelin Proteolipid Protein/IMMUNOLOGY
       Rats  Receptors, Antigen, T-Cell, alpha-beta/ANALYSIS  Receptors,
       Lymphocyte Homing/IMMUNOLOGY  T-Lymphocyte Subsets/IMMUNOLOGY  Th1
       Cells/*IMMUNOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, ACADEMIC

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

