       Document 0371
 DOCN  M9620371
 TI    Pneumocystis carinii pneumonia during treatment for recurrent breast
       cancer: a case report.
 DT    9602
 AU    Koibuchi Y; Iino Y; Yokoe T; Oyama T; Nakajima T; Morishita Y; Second
       Department of Surgery, Gunma University School of; Medicine, Maebashi.
 SO    Jpn J Clin Oncol. 1995 Oct;25(5):218-21. Unique Identifier : AIDSLINE
       MED/96045582
 AB    We describe a case of Pneumocystis carinii pneumonia (PCP) in a woman
       with recurrent breast cancer without human immunodeficiency virus (HIV)
       infection. The PCP was associated with severe lymphocytopenia due to
       treatment with anticancer agents in combination with granulocyte
       colony-stimulating factor (G-CSF). Despite the severe lymphocytopenia,
       the total leucocyte count never fell below 3000/mm3 during the
       treatment. It was difficult to determine whether the patient's
       respiratory failure was caused by severe infectious pneumonia,
       hypersensitivity pneumonia or pneumonitis carcinomatosis. She was
       treated with steroid for suspected drug-induced hypersensitivity
       pneumonia. However, as her condition did not improve, PCP was suspected,
       and sulfamethoxazole-trimethoprim was administered. At the same time,
       anticancer drugs were administered to half the progression of the
       cancer, since lymphangitis carcinomatosa was also suspected. The severe
       respiratory failure did not improve, and the patient died on day 23
       after admission. At autopsy, the cause of death was confirmed to
       respiratory failure due to PCP.
 DE    Adult  Bone Neoplasms/SECONDARY  Breast Neoplasms/*COMPLICATIONS/THERAPY
       Carcinoma, Infiltrating Duct/*COMPLICATIONS/SECONDARY/THERAPY  Case
       Report  Fatal Outcome  Female  Human  Liver Neoplasms/SECONDARY
       Lymphopenia/ETIOLOGY  Pneumonia, Pneumocystis
       carinii/DIAGNOSIS/*ETIOLOGY  Respiratory Insufficiency/ETIOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

