       Document 0589
 DOCN  M9620589
 TI    Ethnic segregation of HTLV-I and HTLV-II carriers among South American
       native Indians.
 DT    9602
 AU    Fujiyoshi T; Yashiki S; Fujiyama C; Kuwayama M; Miyashita H; Ohnishi H;
       Blank M; Zaninovic V; Blank A; Cartier L; et al; Department of Virology,
       Faculty of Medicine, Kagoshima; University, Japan.
 SO    Int J Cancer. 1995 Nov 15;63(4):510-5. Unique Identifier : AIDSLINE
       MED/96074737
 AB    To investigate the genetic background of human T-cell leukemia virus
       type I (HTLV-I) and II (HTLV-II) carriers among South American native
       Indians, we analyzed HLA DRB1*-DQB1* haplotypes of the virus carriers
       from Andes highlands and Orinoco lowlands by the PCR-RFLP genotyping
       method. It was revealed that the HTLV-I-carrying Andes natives had one
       of the 5 HLA haplotypes: DRB1*-DQB1* 0403-0302, 0802-0402, 0901-0303,
       1406-0302 and 0407-0302, and that the Orinoco HTLV-II carriers had one
       of the 3 HLA haplotypes: DRB1*-DQB1* 1402-0301, 1602-0301 and 0404-0302.
       The HLA haplotypes of Andes HTLV-I carriers and Orinoco HTLV-II carriers
       were mutually exclusive. The haplotypes associated with HTLV-I carriers
       were commonly found among the Andes Indians and Japanese, which is the
       known HTLV-I endemic population, while the haplotypes associated with
       HTLV-II carriers were specifically found among the Orinoco Indians and
       North American Indians, among whom HTLV-II is endemic. These results
       suggested that HLA haplotypes might be ethnically segregated among South
       American natives and might be involved in the susceptibility to HTLV-I
       and HTLV-II infections.
 DE    Alleles  Base Sequence  Carrier State/*VIROLOGY  Haplotypes/*GENETICS
       Human  HLA-DQ Antigens/GENETICS  HLA-DR Antigens/GENETICS
       HTLV-I/*GENETICS  HTLV-II/*GENETICS  Indians, South American/*GENETICS
       Molecular Sequence Data  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

