       Document 0013
 DOCN  M9620013
 TI    Delayed latency of the event-related brain potential P3A component in
       HIV disease. Progressive effects with increasing cognitive impairment.
 DT    9602
 AU    Fein G; Biggins CA; MacKay S; Department of Psychiatry, University of
       California-San Francisco,; USA.
 SO    Arch Neurol. 1995 Nov;52(11):1109-18. Unique Identifier : AIDSLINE
       MED/96057018
 AB    OBJECTIVE: To examine the degree to which P3A latency was sensitive to
       the early and progressive effects of human immunodeficiency virus (HIV)
       disease on frontal cortex function by studying HIV-positive subjects who
       varied in degree of cognitive impairment. DESIGN: Event-related brain
       potential studies of four groups of subjects: cognitively nonimpaired
       high-risk HIV-negative subjects, cognitively nonimpaired HIV-positive
       subjects, cognitively mildly to moderately impaired HIV-positive
       subjects, and cognitively severely impaired HIV-positive subjects.
       SETTING: Voluntarily participating subjects on an outpatient basis at a
       medical center facility. PARTICIPANTS: Seventy-one community-residing
       gay or bisexual HIV-positive male volunteers were compared with 17
       HIV-negative male gay or bisexual subjects used as a control sample. The
       HIV-positive subjects were stratified with regard to severity of
       cognitive impairment into the following three subsamples: subjects who
       were cognitively normal (n = 35), subjects with mild to moderate
       cognitive impairment (n = 20), and subjects with severe cognitive
       impairment (n = 16), with the samples closely matched in age. The
       HIV-positive subsamples were closely matched on percentage of CD4
       lymphocytes. Subjects were excluded if they reported a history of drug
       or alcohol abuse, a major mental disorder, a head injury with loss of
       consciousness, or brain disease other than HIV related. MAIN OUTCOME
       MEASURE: P3A latency. RESULTS: P3A latency was significantly delayed in
       HIV-positive subjects compared with HIV-negative control subjects, with
       a delay of 12 milliseconds in the cognitively normal group (P < .02) and
       the magnitude of delay increasing with increasing severity of
       HIV-associated cognitive impairments (P < .001). Delayed P3A was
       primarily associated with the progression of HIV-associated cognitive
       impairment, with a secondary and additive association with severity of
       HIV-associated medical illness. CONCLUSION: This finding suggests that
       delayed P3A latency is sensitive to the relatively early central nervous
       system effects of HIV and progresses with worsening of the central
       nervous system effects of HIV.
 DE    Adult  Auditory Perception  Brain
       Diseases/ETIOLOGY/*PHYSIOPATHOLOGY/PSYCHOLOGY  Brain Mapping  Cognition
       Disorders/*ETIOLOGY/PHYSIOPATHOLOGY  *Evoked Potentials  Human  HIV
       Infections/COMPLICATIONS/*PHYSIOPATHOLOGY/PSYCHOLOGY  Male  Middle Age
       Neuropsychological Tests  Psychomotor Performance  Reaction Time
       Support, U.S. Gov't, Non-P.H.S.  Support, U.S. Gov't, P.H.S.  Visual
       Perception  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

