       Document 0848
 DOCN  M9620848
 TI    Zygomycosis (mucormycosis) and HIV infection: report of three cases and
       review.
 DT    9602
 AU    Nagy-Agren SE; Chu P; Smith GJ; Waskin HA; Altice FL; Department of
       Medicine, Yale University School of Medicine, New; Haven, Connecticut
       06510, USA.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 1;10(4):441-9.
       Unique Identifier : AIDSLINE MED/96074277
 AB    We report three cases of zygomycosis (mucormycosis) occurring in three
       individuals infected with the human immunodeficiency virus (HIV) and
       review 12 other published cases. We present the only two case reports of
       disseminated zygomycosis in AIDS patients, and the only AIDS patient
       with renal zygomycosis to survive without nephrectomy, receiving
       intravenous (i.v.) amphotericin alone. Coinfection with zygomycosis and
       HIV is rare, occurs primarily in patients with low CD4+ lymphocyte
       counts, does not always require the usual predisposing conditions for
       zygomycosis, and may be the presenting opportunistic infection among
       HIV-infected persons. Transient episodes of neutropenia occurring within
       4 months before presentation may be a risk factor for this disease.
       Zygomycosis may arise in multiple sites including the basal ganglia,
       cutaneous tissue, kidney, respiratory tract, and may be disseminated.
       Occurring more commonly in, but not restricted to, injection drug users,
       it is significantly associated with sites other than basal ganglia in
       those patients with advanced HIV disease or AIDS. The presenting
       symptoms are related to the site of involvement, and the illness may
       develop insidiously or progress rapidly to a fulminant course.
       Successful therapy usually consists of surgical debridement and
       intravenous amphotericin B. Overall mortality in this review is 40%, and
       is significantly associated with sites of disease inaccessible to
       surgical debridement.
 DE    Adult  Amphotericin B/THERAPEUTIC USE  Antibiotics,
       Antifungal/THERAPEUTIC USE  AIDS-Related Opportunistic
       Infections/*COMPLICATIONS/DIAGNOSIS/  DRUG THERAPY  Case Report  CD4
       Lymphocyte Count  Female  Fungemia/COMPLICATIONS/DIAGNOSIS  Human
       Intestinal Diseases/COMPLICATIONS/DIAGNOSIS  Intestine,
       Small/MICROBIOLOGY/PATHOLOGY  Kidney/DRUG EFFECTS/MICROBIOLOGY/PATHOLOGY
       Kidney Diseases/COMPLICATIONS/DIAGNOSIS/DRUG THERAPY  Male  Middle Age
       Mucorales/ISOLATION & PURIF  Mucormycosis/*COMPLICATIONS/DIAGNOSIS/DRUG
       THERAPY  Neutropenia/COMPLICATIONS  JOURNAL ARTICLE  REVIEW  REVIEW OF
       REPORTED CASES

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

