       Document 0875
 DOCN  M9620875
 TI    Changes in systemic gonadal and adrenal steroids in asymptomatic human
       immunodeficiency virus-infected men: relationship with the CD4 cell
       counts.
 DT    9602
 AU    Laudat A; Blum L; Guechot J; Picard O; Cabane J; Imbert JC; Giboudeau J;
       Laboratoire de Biochimie-Hormonologie, Hopital Saint-Antoine,; Paris,
       France.
 SO    Eur J Endocrinol. 1995 Oct;133(4):418-24. Unique Identifier : AIDSLINE
       MED/96038764
 AB    Serum sex hormone-binding globulin (SHBG), testosterone, non-SHBG-bound
       testosterone, androstenedione, dihydrotestosterone (DHT),
       dehydroepiandrosterone (DHEA), follicle-stimulating hormone (FSH),
       luteinizing hormone (LH) and cortisol were measured in 58 homosexual men
       seropositive for human immunodeficiency virus (HIV), all clinically
       asymptomatic (Centers for Disease Control 1993 classification stage A).
       The HIV patients were divided into four groups according to the CD4
       lymphocyte count--group 1 (more than 500/microliters, N = 14), group 2
       (between 350 and 500/microliters, N = 16), group 3 (between 200 and
       349/microliters, N = 22) and group 4 (less than 200/microliters, N =
       6)--and compared with 11 antibody-negative men as controls. The SHBG
       levels were significantly increased in groups 1, 2, 3 (p < 0.01) and 4
       (p < 0.05) compared with controls, with no differences between groups of
       patients. Compared with controls, testosterone concentrations were
       significantly lower in group 4 (p < 0.05) and non-SHBG-bound
       testosterone levels were significantly lower in groups 1 (p < 0.05), 2
       (p < 0.01), 3 (p < 0.001) and group 4 (p < 0.001); DHT and
       androstenedione levels were significantly lower in group 4 (p < 0.05)
       and DHEA levels were significantly lower in group 2, group 3 (p < 0.01)
       and group 4 (p < 0.05) than in controls. Cortisol levels were
       significantly increased in groups 1 and 4 (p < 0.05) and FSH and LH
       concentrations were not significantly higher in HIV-infected men than in
       controls. Also, the DHEA, androstenedione, non-SHBG-bound testosterone
       and DHT levels were correlated with CD4 cell counts, showing that
       hypogonadism occurs as the CD4 lymphocytes decrease.(ABSTRACT TRUNCATED
       AT 250 WORDS)
 DE    Acquired Immunodeficiency Syndrome/*BLOOD  Adrenal Cortex
       Hormones/*BLOOD  Adult  Androgens/*BLOOD  Androstenedione/BLOOD  *CD4
       Lymphocyte Count  FSH/BLOOD  Homosexuality, Male  Human
       Hydrocortisone/BLOOD  *HIV-1  LH/BLOOD  Male  Prasterone/BLOOD  Sex
       Hormone-Binding Globulin/METABOLISM  Stanolone/BLOOD  Testosterone/BLOOD
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

