       Document 0461
 DOCN  M9620461
 TI    Detection of HCV RNA in serum and seminal fluid from HIV-1 co-infected
       intravenous drug addicts.
 DT    9602
 AU    Fiore RJ; Potenza D; Monno L; Appice A; DiStefano M; Giannelli A;
       LaGrasta L; Romanelli C; DiBari C; Pastore G; Clinic of Infectious
       Diseases, University of Bari, Italy.
 SO    J Med Virol. 1995 Aug;46(4):364-7. Unique Identifier : AIDSLINE
       MED/96061542
 AB    The presence of hepatitis C virus (HCV) RNA in serum and seminal fluid
       was investigated in eleven drug addicts coinfected with HIV-1 and HCV.
       Serum and seminal fluid were taken from each patient at the same time
       point. HCV RNA was found in ten of the eleven serum samples tested, but
       only in one of the semen samples. No relationship was observed between
       CD4 cell counts, the stage of HIV infection, extent of liver damage and
       the presence of HCV RNA in serum and semen. The results indicate that
       HCV is not usually present in the semen and provide further evidence
       against sexual transmission as an important mode of transmission of HCV
       infection.
 DE    AIDS-Related Opportunistic Infections/BLOOD/COMPLICATIONS/  *VIROLOGY
       Base Sequence  CD4 Lymphocyte Count  DNA Primers  Hepatitis
       B/COMPLICATIONS/IMMUNOLOGY  Hepatitis B Antibodies/ANALYSIS  Hepatitis
       C/BLOOD/COMPLICATIONS/TRANSMISSION/*VIROLOGY  Hepatitis C
       Viruses/*ISOLATION & PURIF  Human  *HIV-1  Male  Molecular Sequence Data
       RNA, Viral/ANALYSIS/BLOOD  Semen/*VIROLOGY  Substance Abuse,
       Intravenous/*COMPLICATIONS  Substance Dependence  Support, Non-U.S.
       Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

