       Document 0729
 DOCN  M9620729
 TI    Gamma delta T cells in rhesus monkeys and their response to simian
       immunodeficiency virus (SIV) infection.
 DT    9602
 AU    Gan YH; Pauza CD; Malkovsky M; Department of Medical Microbiology and
       Immunology, University of; Wisconsin Medical School, Madison 53706, USA.
 SO    Clin Exp Immunol. 1995 Nov;102(2):251-5. Unique Identifier : AIDSLINE
       MED/96069871
 AB    Recent reports of the increase in peripheral blood gamma delta T cells
       in HIV+ patients prompted us to examine the gamma delta T cell system in
       rhesus monkeys (Macaca mulatta) and the responses of these cells to SIV
       infection. Our results reveal differences in the gamma delta T cell
       subset composition and their expression of CD8 in the peripheral blood
       of monkeys and humans. The outgrowth of simian gamma delta T cells in
       response to Daudi cells is similar to that in humans, but the exposure
       to IL-2 stimulates preferentially the simian V delta 1 subset rather
       than the V gamma 9/V delta 2 subset as found in humans. Upon SIV
       infection of the monkeys, we observed a transient increase of the
       percentage of total gamma delta T cell and the V gamma 9 subset. gamma
       delta T cells from infected animals also express more activation markers
       such as CD69, CD44 and the memory marker CD45RO. However, they respond
       to a lesser degree to Daudi or IL-2 stimulation in the outgrowth
       experiments compared with uninfected animals, although the subset
       composition of total gamma delta T cells is similar in infected and
       uninfected animals. The results clearly indicate that gamma delta T
       cells in rhesus monkeys are influenced by SIV infection. The detailed
       analysis of the gamma delta T cell response to SIV infection can serve
       as a model for understanding human gamma delta T cell responses to HIV
       infections.
 DE    Animal  Antigens, CD/METABOLISM  Antigens, CD44/METABOLISM  Antigens,
       Differentiation, T-Lymphocyte/METABOLISM  CD4 Lymphocyte Count  Gene
       Rearrangement, delta-Chain T-Cell Antigen Receptor  Human
       Immunophenotyping  Lymphocyte Transformation  Macaca mulatta  Receptors,
       Antigen, T-Cell, gamma-delta/IMMUNOLOGY  Simian Acquired
       Immunodeficiency Syndrome/*IMMUNOLOGY  Support, Non-U.S. Gov't  Support,
       U.S. Gov't, P.H.S.  T-Lymphocyte Subsets/*IMMUNOLOGY  Tumor Cells,
       Cultured/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

