       Document 0001
 DOCN  M9620001
 TI    A reexamination of the relationship between active rheumatoid arthritis
       and the acquired immunodeficiency syndrome.
 DT    9602
 AU    Ornstein MH; Kerr LD; Spiera H; Mount Sinai Medical Center, New York,
       New York 10029-6574, USA.
 SO    Arthritis Rheum. 1995 Nov;38(11):1701-6. Unique Identifier : AIDSLINE
       MED/96062446
 AB    Three patients with rheumatoid arthritis (RA) that remitted with the
       development of the human immunodeficiency virus (HIV) infection have
       been described in the literature, and this has contributed to the belief
       that RA and HIV infection or the acquired immunodeficiency syndrome
       (AIDS) cannot coexist. However, a computerized MEDLINE literature search
       revealed reports of 4 patients who did have active RA and AIDS or HIV
       infection, as well as other case reports of symmetric polyarthritis
       compatible with RA in patients with HIV infection. Each of the patients
       whose RA remitted had received standard disease-modifying antirheumatic
       drug therapy, and 1 of the 3 had a normal T helper:T suppressor ratio at
       the time of remission. Of the 4 previously reported patients with active
       RA and AIDS or HIV infection, all had decreased numbers of T helper
       lymphocytes. The present report describes a fifth patient with both RA
       and AIDS and reviews the data concerning the coexistence of these 2
       diseases. It appears that active RA may indeed coexist with AIDS. It
       remains to be seen under what settings HIV may have a disease-modifying
       effect in RA. These issues have important implications regarding the
       pathogenesis and therapy of RA, especially in terms of the role of CD4+
       lymphocytes and anti-CD4 monoclonal antibody therapy.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/*COMPLICATIONS/PATHOLOGY  Adult
       Arthritis, Rheumatoid/BLOOD/*COMPLICATIONS/PATHOLOGY  Case Report
       CD4-CD8 Ratio  CD4-Positive T-Lymphocytes/CYTOLOGY  Female  Human
       Lymphocyte Count  Male  Middle Age  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

