       Document 0665
 DOCN  M9620665
 TI    [Anxious-depressive state and cognitive deficit in HIV infection]
 DT    9602
 AU    Silvestre D; Linard F; Desi M; Seibel N; Korezlioglu J; Pequart C;
       Saimot AG; U158 INSERM, Hopital Necker-Enfants Malades, Paris.
 SO    Encephale. 1995 Jul-Aug;21(4):285-8. Unique Identifier : AIDSLINE
       MED/96004061
 AB    This study tries to demonstrate the importance of using follow-up trials
       and taking anxio-depressive status into account while interpreting
       cognitive impairment in HIV-infected subjects. Subjects included were:
       18 HIV carriers, mostly homosexual, belonging to CDC groups II (4), III
       or IVC2 (7) and IV (7), selected within a cohort of 63, as having been
       assessed 3 times, with no focal or identified brain disease at entry.
       Our methods were: 1) psychiatric interview based on DSM III-R criteria,
       clinical scales (Spielberger's STAXI and the MADRS) and cognitive
       questionnaires; 2) neuropsychological evaluation including 16 subtests
       screening attention, memory, visuo-spatial function, motor dexterity,
       psychomotor speed, and language; 3) repeated assessment within a period
       ranging from 6 to 21 months. Results: At entry, cognitive status was
       impaired for 14 subjects (2 II, 5 III or IVC2, 7 IV). Disorders had
       disappeared for 7 subjects (2 II, 2 IVC2 and 3 IV) at following
       assessments allowing us to conclude on a psychogenic origin. For 7
       subjects, cognitive status had either remained constant (3 III and 2 II)
       or had worsened within 7 to 17 months (2 IV), whereas psychiatric
       symptoms had decreased, implying HIV encephalopathy. Follow-up trials
       including 3 neuropsychological and psychiatric assessments and
       neuroimagery, if necessary, were required to ascertain the causes of
       cognitive impairment consequently attributed to anxio-depressive
       symptoms or HIV encephalopathy in 14 subjects.
 DE    Adult  Aged  Anxiety Disorders/DIAGNOSIS/*PSYCHOLOGY  AIDS Dementia
       Complex/DIAGNOSIS/*PSYCHOLOGY  Cohort Studies  Depressive
       Disorder/DIAGNOSIS/*PSYCHOLOGY  English Abstract  Female  Homosexuality,
       Male/PSYCHOLOGY  Human  HIV Seropositivity/DIAGNOSIS/*PSYCHOLOGY  Male
       Middle Age  Neuropsychological Tests  Personality Inventory  Sick Role
       JOURNAL ARTICLE

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