       Document 0447
 DOCN  M9620447
 TI    [AIDS dementia. Prognosis and therapeutic perspectives]
 DT    9602
 AU    Lubetzki C; Inserm U-134, Hopital de la Salpetriere, Paris.
 SO    J Neuroradiol. 1995 Sep;22(3):169-71. Unique Identifier : AIDSLINE
       MED/96043311
 AB    AIDS dementia complex is a severe complication related to HIV infection
       of the central nervous system. It has been estimated to affect about 7%
       of AIDS patients, with an increased frequency in very young and old
       patients. In most cases, it appears in severely immuno-deficient
       patients. Typically, AIDS dementia presents as a subcortical dementia
       with cognitive, behavioural and motor decline. The mechanism of the
       dementia remains unclear; the neuronal loss is controversial and a
       neurotoxicity due to NMDA receptor activation is likely. No treatment
       proved to be efficient. Beneficial effect of anti-NMDA receptor
       antagonists are under investigation.
 DE    Adult  Age Factors  AIDS Dementia Complex/DRUG
       THERAPY/PHYSIOPATHOLOGY/*THERAPY  English Abstract  Human  Middle Age
       Neurons/PATHOLOGY  Prognosis  Receptors,
       N-Methyl-D-Aspartate/ANTAGONISTS & INHIB/PHYSIOLOGY  JOURNAL ARTICLE
       REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

