       Document 0444
 DOCN  M9620444
 TI    [CMV and VZV encephalitis in AIDS]
 DT    9602
 AU    Hassine D; Gray F; Chekroun R; De Truchis P; Schouman-Claeys E; Vallee
       C; Service de Radiologie, Hopital Raymond Poincare, Garches.
 SO    J Neuroradiol. 1995 Sep;22(3):184-92. Unique Identifier : AIDSLINE
       MED/96043314
 AB    MATERIAL AND METHODS: Eighty patients were followed up prospectively.
       Histological correlation was obtained in 25 cases. All MRI examinations
       were performed on at 0.5 Tesla in T1-weighted sequences with and without
       gadolinium injection, and in axial or frontal T2-weighted spin echo
       sequences. Histological confirmation was obtained 30 days on average
       after the last MRI examination. Immunohistochemical stainings were
       performed in search of CMV, VZV, toxoplasma, HIV antigen and lymphoma.
       RESULTS: CMV meningoencephalitis was found in 6 cases. In 3 of these it
       was manifested by atrophy, either isolated or associated with high
       signal intensity punctiform areas. Histology detected cortical or
       subcortical microglial nodules. In 2 cases MRI displayed abnormalities
       of subependymal nodular signals without enhancement, associated with
       punctiform abnormalities of subcortical signals. Histology showed
       subependymal foci of necrosis and abnormalities of white matter. In one
       case, MRI showed a ventriculitis confirmed by histology. VZV
       meningoencephalitis was diagnosed in 2 cases. MRI displayed abnormal
       basal ganglia related to meningitis (n = 1). All abnormalities were
       confirmed at histology. CONCLUSION: Some images (ventriculitis,
       infarction in basal ganglia, abnormal subependymal signal) would suggest
       VZV and CMV encephalitis. Other images (abnormalities of punctiform
       signals or atrophy) are not specific.
 DE    Atrophy  AIDS-Related Opportunistic Infections/*DIAGNOSIS/PATHOLOGY
       Basal Ganglia Diseases/DIAGNOSIS/PATHOLOGY/VIROLOGY  Cerebral
       Ventricles/PATHOLOGY  Contrast Media  Cytomegalovirus
       Infections/*DIAGNOSIS/PATHOLOGY  Encephalitis,
       Viral/*DIAGNOSIS/PATHOLOGY  English Abstract  Ependyma/PATHOLOGY
       Follow-Up Studies  Gadolinium/DIAGNOSTIC USE  Herpes
       Zoster/*DIAGNOSIS/PATHOLOGY  Human  Immunohistochemistry  *Magnetic
       Resonance Imaging  Meningoencephalitis/DIAGNOSIS/PATHOLOGY/VIROLOGY
       Microglia/PATHOLOGY  Necrosis  Prospective Studies  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

