       Document 0446
 DOCN  M9620446
 TI    [MRI aspects of progressive multifocal leukoencephalopathy]
 DT    9602
 AU    Sarrazin JL; Soulie D; Derosier C; Lescop J; Schill H; Cordoliani YS;
       H.I.A du Val-de-Grace, Paris.
 SO    J Neuroradiol. 1995 Sep;22(3):172-9. Unique Identifier : AIDSLINE
       MED/96043312
 AB    Progressive Multifocal Leukoencephalopathy is a demyelinating disease.
       MRI shows high signal intensity areas on T2w sequence and low intensity
       aeras on T1w sequence, without enhancement after intravenous contrast
       injection. The involvement of arcuate fiber (U fibers) creates a sharp
       border with the cortex. There is no mass effect. Involvement of
       parieto-occipital areas is frequent. The lesions may be uni or
       bilateral, single or multiple; bilateral lesions are asymmetric. This
       typical appearance on MR images occurs in 90% of the patients with PML.
       Some atypical patterns may occur: focal hemorrhage, atrophy, faint
       peripheral enhancement and involvement of deep gray matter (basal
       ganglia). In most cases, the clinical and MR features provide the
       diagnosis. The main differential diagnosis, in MRI, is
       HIV-leukoencephalitis, but lesions are diffuse, less intense on T2w
       sequence and not visible on T1, without involvement of the arcuate
       fibers. Stereotactic biopsy should be performed only for atypical
       lesions, particularly in case of predominant involvement of deep gray
       structures.
 DE    Arcuate Nucleus/PATHOLOGY  Atrophy  AIDS Dementia Complex/DIAGNOSIS
       Biopsy  Cerebral Cortex/PATHOLOGY  Cerebral Hemorrhage/DIAGNOSIS
       Contrast Media  Diagnosis, Differential  English Abstract  Human
       Leukoencephalopathy, Progressive Multifocal/*DIAGNOSIS  *Magnetic
       Resonance Imaging  Stereotaxic Techniques  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

