       Document 0604
 DOCN  M9620604
 TI    Human lactoferrin induces phenotypic and functional changes in murine
       splenic B cells.
 DT    9602
 AU    Zimecki M; Mazurier J; Spik G; Kapp JA; Institute of Immunology and
       Experimental Therapy, Polish Academy; of Sciences, Wroclaw, Poland.
 SO    Immunology. 1995 Sep;86(1):122-7. Unique Identifier : AIDSLINE
       MED/96091081
 AB    The immunotropic activities of human lactoferrin were studied with
       respect to phenotypic and functional changes in murine splenic B cells.
       Phenotypic changes were induced by human lactoferrin in splenic B-cell
       fractions separated by buoyant density. B cells from 7-8-day-old BALB/c
       mice isolated from a 50/60% Percoll gradient, gained characteristic
       features of more mature B cells manifested by an increase of surface IgD
       and complement receptor expression. Incubation of the analogous B-cell
       fraction from adult mice with human lactoferrin resulted in minor
       changes in relation to IgM and IgD expression. Besides induction of
       phenotypic changes on immature B cells, human lactoferrin enabled B
       cells from normal newborn and adult immunodeficient CBA/N mice to
       present antigen to an antigen-specific T-helper type 2 (Th2) cell line.
       We conclude that human lactoferrin acts as a maturation factor for B
       cells with regard to their phenotype and function.
 DE    Animal  Animals, Newborn  Antigen Presentation/DRUG EFFECTS
       B-Lymphocytes/CYTOLOGY/*DRUG EFFECTS/IMMUNOLOGY  Cell Division  Cell
       Line  Human  IgD/*IMMUNOLOGY  IgM/*IMMUNOLOGY  Lactoferrin/*PHARMACOLOGY
       Macrophage-1 Antigen/IMMUNOLOGY  Mice  Mice, Inbred BALB C  Mice, Inbred
       CBA  Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  Th2
       Cells/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

