       Document 0220
 DOCN  M9620220
 TI    Adrenergic blockade ameliorates cellular immune responses to mental
       stress in humans.
 DT    9602
 AU    Bachen EA; Manuck SB; Cohen S; Muldoon MF; Raible R; Herbert TB; Rabin
       BS; Brain Behavior and Immunity Center, University of Pittsburgh, PA;
       15260, USA.
 SO    Psychosom Med. 1995 Jul-Aug;57(4):366-72. Unique Identifier : AIDSLINE
       MED/96076059
 AB    This study evaluated the sympathoadrenal modulation of behaviorally
       evoked immune responses by administration of a nonselective adrenoceptor
       antagonist (labetalol) to subjects exposed to mental stress. In a 2 x 2
       factorial design, subjects were assigned to a labetalol or saline
       condition and, within each condition, were exposed either to acute
       laboratory stress or no stress (control). Lymphocyte subsets, natural
       killer (NK) cell cytotoxicity, and T cell proliferation to
       phytohemagglutinin and concanavalin A were assessed pre-experimentally,
       at baseline after infusion and after 18 minutes of mental stress (or
       rest). By comparison with the other three conditions, the saline-stress
       group showed a greater peripheral NK cell number and cytotoxicity, lower
       mitogenic response to phytohemagglutinin and concanavalin A, and
       diminished ratio of CD4:CD8 cells after the stressor. As predicted,
       immune responses did not differ among the remaining groups
       (labetalol-stress, saline-rest, labetalol-rest). Group differences in NK
       cell cytotoxicity were not significant after controlling for differences
       in NK cell numbers. These findings demonstrate that the occurrence of
       certain immunologic responses to acute psychological stress are
       dependent on concomitant activation of the sympathetic nervous system.
 DE    Adolescence  Adrenal Glands/INNERVATION  Adrenergic
       alpha-Antagonists/*PHARMACOLOGY  Adrenergic
       beta-Antagonists/*PHARMACOLOGY  Adult  Blood Pressure/DRUG
       EFFECTS/PHYSIOLOGY  Cytotoxicity, Immunologic/*DRUG EFFECTS/IMMUNOLOGY
       CD4-CD8 Ratio/DRUG EFFECTS  Heart Rate/DRUG EFFECTS/PHYSIOLOGY  Human
       Immune Tolerance/DRUG EFFECTS/IMMUNOLOGY  Killer Cells, Natural/DRUG
       EFFECTS/IMMUNOLOGY  Labetalol/*PHARMACOLOGY  Lymphocyte Count/DRUG
       EFFECTS  Lymphocyte Subsets/*DRUG EFFECTS/IMMUNOLOGY  Lymphocyte
       Transformation/*DRUG EFFECTS/IMMUNOLOGY  Male  Stress,
       Psychological/*COMPLICATIONS/IMMUNOLOGY  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  Sympathetic Nervous System/DRUG
       EFFECTS/PHYSIOLOGY  T-Lymphocytes/DRUG EFFECTS/IMMUNOLOGY  CLINICAL
       TRIAL  JOURNAL ARTICLE  RANDOMIZED CONTROLLED TRIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

