       Document 0907
 DOCN  M9620907
 TI    Production in rabbits of high levels of anti-HIV-1 gp160 antibodies.
 DT    9602
 AU    Relyveld E; Bizzini B; Institut Pasteur, Unite des Vaccins Bacteriens,;
       Marnes-La-Coquette, France.
 SO    Cell Mol Biol (Noisy-le-grand). 1995 May;41(3):389-93. Unique Identifier
       : AIDSLINE MED/96059399
 AB    The production of anti-HIV-1 gp160 antibodies was obtained in rabbits
       given gp160 either in saline or adsorbed onto calcium phosphate.
       Immunization with gp160 in saline induced the formation of antibodies
       directed to the p18 protein, whereas the gp160 adsorbed onto calcium
       phosphate elicited antibodies recognizing the gp160, p55, p25 and p18
       proteins. Calcium phosphate was found to be a powerful adjuvant and it
       should be used for potentiating candidate anti-HIV vaccines.
 DE    Adjuvants, Immunologic/ADMINISTRATION & DOSAGE  Animal  Blotting,
       Western  Calcium Phosphates/IMMUNOLOGY  Enzyme-Linked Immunosorbent
       Assay  Gene Products, env/*IMMUNOLOGY  Gene Products, gag/IMMUNOLOGY
       HIV Antibodies/*BIOSYNTHESIS  HIV-1/IMMUNOLOGY  Male  Protein
       Precursors/*IMMUNOLOGY  Rabbits  Radioimmunoprecipitation Assay  Time
       Factors  Vaccination  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

