       Document 0950
 DOCN  M9620950
 TI    Isolated renal mucormycosis: case report and review.
 DT    9602
 AU    Levy E; Bia MJ; Section of Nephrology, Yale University School of
       Medicine, New; Haven, CT, USA.
 SO    J Am Soc Nephrol. 1995 Jun;5(12):2014-9. Unique Identifier : AIDSLINE
       MED/96073207
 AB    The 15th reported case of isolated renal mucormycosis (infection of the
       kidney with fungus of the order Mucorales, in the absence of infection
       elsewhere in the body) is presented. The patient was a 36-year-old human
       immunodeficiency virus-infected man, actively using iv drugs, who
       suffered 6 wk of flank pain and fever before diagnosis was made by
       percutaneous renal biopsy. He received 4 months of amphotericin B
       treatment, then no therapy for 6 months before dying with no evidence of
       mucormycosis. Isolated renal mucormycosis should be suspected in those
       with an underlying immunocompromising illness or history of iv drug use
       who have persistent flank pain and fever, but sterile urine cultures.
       Computed tomographic scanning with contrast should then be performed;
       findings of severe inflammation or bacterial infection, despite an
       indolent clinical course with sterile or nondiagnostic urine and blood
       cultures, are suggestive of isolated renal mucormycosis, and renal
       biopsy under computed tomographic guidance should be performed, despite
       the potential risk of disseminated infection. Although our patient was
       treated with amphotericin B alone, nephrectomy with or without
       amphotericin B therapy appears to be more likely to cure infection and
       relieve pain and constitutional symptoms.
 DE    Adult  Amphotericin B/THERAPEUTIC USE  Antibiotics, Combined/THERAPEUTIC
       USE  AIDS-Related Opportunistic Infections/DIAGNOSIS/*MICROBIOLOGY
       Biopsy  Case Report  Fatal Outcome  Human  Kidney/MICROBIOLOGY/PATHOLOGY
       Male  *Mucormycosis/DIAGNOSIS/DRUG THERAPY/PHYSIOPATHOLOGY  Nephrectomy
       Pyelonephritis/DIAGNOSIS/DRUG THERAPY/*MICROBIOLOGY/  PHYSIOPATHOLOGY
       JOURNAL ARTICLE  REVIEW  REVIEW OF REPORTED CASES

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

