       Document 0378
 DOCN  M9620378
 TI    Cell cycle dependence of foamy retrovirus infection.
 DT    9602
 AU    Bieniasz PD; Weiss RA; McClure MO; Department of GU Medicine and
       Communicable Diseases, Jefferiss; Research Trust, St. Mary's Hospital
       Medical School, London,; United Kingdom.
 SO    J Virol. 1995 Nov;69(11):7295-9. Unique Identifier : AIDSLINE
       MED/96013840
 AB    In common with oncoviruses but unlike the lentivirus human
       immunodeficiency virus type 1, foamy (spuma) viruses require host cell
       proliferation for productive infection. We show that human
       immunodeficiency virus type 1 replicates in RD-CD4 cells regardless of
       the growth arrest condition of the cells, while murine leukemia virus is
       unable to infect growth-arrested RD-CD4 cells or cells progressing
       through a partial cell cycle that includes S phase but not mitosis.
       Human foamy virus, like murine leukemia virus, does not productively
       infect G1/S or G2 growth-arrested cells. Two other foamy viruses, simian
       foamy virus type 1, isolated from a macaque, and simian foamy virus type
       6, isolated from a chimpanzee, also fail to establish productive
       infection in G1/S-arrested cells.
 DE    Animal  Aphidicolin/PHARMACOLOGY  *Cell Cycle/DRUG EFFECTS/RADIATION
       EFFECTS  Cell Division  Cell Line  Chimpansee troglodytes/VIROLOGY
       Comparative Study  CD4-Positive T-Lymphocytes/VIROLOGY  G1 Phase  G2
       Phase  Human  HIV-1/*PHYSIOLOGY/PATHOGENICITY  Leukemia Viruses,
       Murine/PHYSIOLOGY  Macaca/VIROLOGY  Species Specificity
       Spumavirus/ISOLATION & PURIF/*PHYSIOLOGY/PATHOGENICITY  Support,
       Non-U.S. Gov't  *Virus Replication  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

