       Document 0623
 DOCN  M9620623
 TI    The role of oxidative stress in HIV disease.
 DT    9602
 AU    Pace GW; Leaf CD; Research Triangle Pharmaceuticals, Durham, NC, USA.
 SO    Free Radic Biol Med. 1995 Oct;19(4):523-8. Unique Identifier : AIDSLINE
       MED/96015038
 AB    Evidence has accumulated suggesting that HIV-infected patients are under
       chronic oxidative stress. Perturbations to the antioxidant defense
       system, including changes in levels of ascorbic acid, tocopherols,
       carotenoids, selenium, superoxide dismutase, and glutathione, have been
       observed in various tissues of these patients. Elevated serum levels of
       hydroperoxides and malondialdehyde also have been noted and are
       indicative of oxidative stress during HIV infection. Indications of
       oxidative stress are observed in asymptomatic HIV-infected patients
       early in the course of the disease. Oxidative stress may contribute to
       several aspects of HIV disease pathogenesis, including viral
       replication, inflammatory response, decreased immune cell proliferation,
       loss of immune function, apoptosis, chronic weight loss, and increased
       sensitivity to drug toxicities. Glutathione may play a role in these
       processes, and thus, agents that replete glutathione may offer a
       promising treatment for HIV-infected patients. Clinical studies are
       underway to evaluate the efficacy of the glutathione-repleting agents,
       L-2-oxothiazolidine-4-carboxylic acid (OTC) and N-acetylcysteine (NAC),
       in HIV-infected patients.
 DE    Antioxidants  Human  HIV/PHYSIOLOGY  *HIV
       Infections/ETIOLOGY/IMMUNOLOGY/METABOLISM/VIROLOGY  *Oxidative Stress
       Virus Replication  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

