       Document 0680
 DOCN  M9620680
 TI    Idiopathic CD4+ T-lymphocytopenia: analysis of a patient with selective
       IgA deficiency and no evidence of HIV infection.
 DT    9602
 AU    Vertes D; Linden MD; Carey JL; Department of Pathology, Henry Ford
       Hospital, Detroit, Michigan; 48202, USA.
 SO    Cytometry. 1995 Mar 15;22(1):40-4. Unique Identifier : AIDSLINE
       MED/96090281
 AB    Idiopathic CD4+ T-lymphocytopenia (ICL) in HIV-seronegative patients is
       a newly described, rare entity. The common underlying abnormality is a
       usually stable depletion in CD4+ lymphocytes in patients, some of which
       have unexplained opportunistic infections. We present a previously
       unreported condition of an asymptomatic individual with CD4+
       T-lymphocytopenia and a selective IgA deficiency. The subject is a
       35-year-old healthy white male with a documented 5-year history of low
       CD4+ T cell counts. He has been repeatedly HIV seronegative and has no
       risk factors for HIV infection. Data were obtained from several
       laboratories over a 5-year period and include standard WBC
       differentials, HIV testing, serum immunoglobulin quantitation, mitogen
       stimulation assays, diphtheria and tetanus antitoxin titers, and flow
       cytometric immunophenotyping. The composite results show a subject with
       a normal white blood cell count, an absolute lymphopenia, a slight
       granulocytosis, and a selective IgA deficiency. Leukocyte subset
       analyses show essentially normal B but significantly altered T cell
       phenotypes. The normal CD4:CD8 ratio shows extreme inversion, primarily
       due to CD4 T-lymphocytopenia.
 DE    Adult  Case Report  Comparative Study  CD4 Lymphocyte Count  Human  HIV
       Seronegativity/*IMMUNOLOGY  IgA Deficiency/*IMMUNOLOGY  Male  Risk
       Factors  T-Lymphocytopenia, Idiopathic CD4-Positive/*ETIOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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