       Document 0457
 DOCN  M9620457
 TI    Coherent view of non-Hodgkin's lymphoma.
 DT    9602
 AU    Aisenberg AC; Hematology/Oncology Unit, Massachusetts General Hospital,
       Boston; 02114, USA.
 SO    J Clin Oncol. 1995 Oct;13(10):2656-75. Unique Identifier : AIDSLINE
       MED/96007593
 AB    PURPOSE: Even though non-Hodgkin's lymphoma is already sixth in
       incidence and mortality among malignant neoplasms (and the incidence was
       increasing at a rate of 3% to 4% per year before the advent of AIDS
       epidemic-associated lymphomas), most physicians and many oncologists
       find the disorder arcane. The problem lies in the complexity of human
       lymphoma, which encompasses more than a dozen neoplasms of the lymphoid
       system. The goal of this review is to provide user-friendly access to
       the condition. METHODS: The variety of inputs required for a subdivision
       of non-Hodgkin's lymphoma that is useful to clinicians includes
       lymphocyte lineage and sublineage based on microscopic appearance and
       immunophenotype, clinical behavior manifest in survival and early
       dissemination, and analysis of molecular genetic and cytogenetic
       abnormalities, which reflect pathogenic oncogene derangements.
       Epstein-Barr virus (EBV) and human T-cell leukemia virus type 1 (HTLV-1)
       are important in certain uncommon lymphomas. RESULTS AND CONCLUSION: The
       subtypes of primary B-lineage nodal lymphoma include low-grade (small
       lymphocytic, lymphoplasmacytic-lymphoplasmacytoid, follicular small
       cleaved cell, and follicular mixed small cleaved and large cell),
       intermediate-grade (follicular large cell, diffuse small cleaved or
       mixed, and intermediate lymphocytic), and high-grade (diffuse large
       cell, immunoblastic, and small noncleaved cell) neoplasms. The less
       common lymphomas of T lineage and lymphomas that arise in extranodal
       sites are placed in separate subdivisions. This subdivision serves as a
       guide to prognosis and treatment.
 DE    Animal  Human  Lymphoma, AIDS-Related/DIAGNOSIS/ETIOLOGY/THERAPY
       Lymphoma, Non-Hodgkin's/CLASSIFICATION/ETIOLOGY/*THERAPY  JOURNAL
       ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

