       Document 0938
 DOCN  M9620938
 TI    Critical role of CD28/B7 costimulation in the development of human Th2
       cytokine-producing cells.
 DT    9602
 AU    Webb LM; Feldmann M; Kennedy Institute of Rheumatology, Sunley Division,
       Hammersmith,; London, UK.
 SO    Blood. 1995 Nov 1;86(9):3479-86. Unique Identifier : AIDSLINE
       MED/96027516
 AB    CD28 is a major costimulatory signal receptor for T cells. We have used
       human naive CD4+ cells from cord blood to analyze the effect of the
       CD28/B7 costimulatory pathway on development of T helper (Th) subsets.
       We show that CD28 costimulation is critical for development of the Th2
       cytokine-producing cells and that in the absence of CD28 costimulation,
       cells are not primed to produce Th2 cytokines and consequently default
       to the Th1 subset, independent of the presence of exogenous cytokines.
       After CD28 costimulation, cells differentiate into a subset that
       produces Th2 cytokines. However, further CD28 costimulation is not
       required to maintain Th2 cytokine production. We conclude that D28
       costimulation is critical for the development of Th0 and Th2 subsets,
       but not for the maintenance of cytokine production.
 DE    Animal  Antigens, CD28/*PHYSIOLOGY  Antigens, CD80/*PHYSIOLOGY
       Comparative Study  Human  Immunologic Memory  Infant, Newborn
       Interleukin-2/PHARMACOLOGY  *Lymphocyte Transformation/DRUG EFFECTS
       Lymphokines/SECRETION  Mice  Muromonab-CD3/PHARMACOLOGY  Support,
       Non-U.S. Gov't  Th1 Cells/CYTOLOGY  Th2 Cells/DRUG
       EFFECTS/*IMMUNOLOGY/SECRETION  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

