       Document 0865
 DOCN  M9620865
 TI    [African histoplasmosis due to Histoplasma capsulatum var. duboisii:
       relationship with AIDS in recent Congolese cases]
 DT    9602
 AU    Chandenier J; Goma D; Moyen G; Samba-Lefebvre MC; Nzingoula S; Obengui;
       Mbitsi A; Nkiwabonga L; Ngaporo AI; Service de parasitologie-mycologie,
       CHU de Brazzaville, Congo.
 SO    Sante. 1995 Jul-Aug;5(4):227-34. Unique Identifier : AIDSLINE
       MED/96016648
 AB    Six new cases are described for African histoplasmosis, Histoplasma
       capsulatum var. duboisii, from Congo. The first was an HIV sero-negative
       child who has been monitored for the last three years. While under
       treatment with ketoconazole, amphotericin B, and finally itraconazole,
       the development of the infection was accompanied by purulent lesions,
       mainly cutaneous, but also superficial and deep lymphadenopathies. As a
       last option, itraconazole gave very satisfactory results both during the
       acute phase and during long-term treatment. However, eight months after
       treatment had ceased, there was a relapse and the long-term treatment
       had to be restarted. The other cases concerned HIV sero-positive
       patients with disseminated infections that had all been mistaken for
       tuberculosis. After diagnosis of the infection in two cases, the
       following two years of treatment could not prevent death. A fourth case,
       diagnosed in December 1994, is currently undergoing treatment. The fifth
       subject was lost after diagnosis during follow-up, but inquires made
       after the discovery of the patient's death strongly indicated acquired
       immunodeficiency as the cause. The last of these six cases, determined
       as HIV sero-negative, showed large bony lesions of the spinal column
       associated with a sore on the thorax. Thus, in a short period of time,
       three or four cases of African histoplasmosis occurred which were
       associated with HIV infection. Only seven identical observations have
       previously been reported in the literature. Therefore, we believe that
       this mycosis should now be included in the criteria for the diagnosis
       and definition of AIDS in the tropics.
 DE    Adult  AIDS-Related Opportunistic Infections/DIAGNOSIS/DRUG THERAPY/
       *MICROBIOLOGY  Case Report  Congo  English Abstract  Fatal Outcome
       Female  Histoplasma/*CLASSIFICATION  Histoplasmosis/DIAGNOSIS/DRUG
       THERAPY/*MICROBIOLOGY  Human  Male  Middle Age  Recurrence  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

