       Document 0857
 DOCN  M9620857
 TI    HIV-associated renal disease in London hospitals.
 DT    9602
 AU    Connolly JO; Weston CE; Hendry BM; Department of Medicine, King's
       College Hospital School of; Medicine and Dentistry, London, UK.
 SO    QJM. 1995 Sep;88(9):627-34. Unique Identifier : AIDSLINE MED/96030958
 AB    We report experience from London hospitals which further illustrates the
       heterogeneous nature of HIV-associated nephropathy (HIVAN). Nineteen
       HIV-positive patients underwent renal biopsy from 1992 to 1994. Fourteen
       were male, five female. Eleven were Afro-Caribbean, 7 Caucasian and 1
       Asian. Eleven patients had classical HIVAN with proteinuria, rapidly
       progressive renal failure and features of focal and segmental
       glomerulosclerosis (FSGS) on renal biopsy, and three of these had
       associated tubulo-interstitial nephritis (TIN). One further patient had
       TIN and tubular changes suggestive of HIVAN but no glomeruli were
       present in the biopsy. Other biopsy findings were of focal proliferative
       glomerulonephritis and TIN (1 patient), pauci-immune crescentic
       glomerulonephritis and TIN (1 patient), membranous nephropathy (1
       patient), membranoproliferative nephropathy (1 patient) and haemolytic
       uraemic syndrome (2 patients). Of 11 patients with FSGS, seven died with
       median survival of 8 months (range 23 days-46 months) and five are still
       alive after median follow-up of 18 months (range 10-22 months). Of
       patients with glomerular disease other than FSGS, five died, with median
       survival of 3 months (range 1-27 months) and two have survived (10 and
       27 months, respectively). Thirteen patients had renal failure, 10 of
       whom had FSGS. In 10 cases renal failure was acute and in two was the
       presenting feature of HIV infection. Thirteen patients underwent renal
       replacement therapy. Four received haemodialysis, and all died within
       one month. Nine patients received CAPD. Two were able to discontinue
       dialysis. Of the remaining seven, five died with median survival of 8
       months (range 1.3-40 months) and two are alive 1 and 10 months after
       beginning dialysis.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adult
       AIDS-Associated Nephropathy/*PATHOLOGY  Female  Follow-Up Studies
       Glomerulonephritis/PATHOLOGY/VIROLOGY  Hemodialysis  Human  Kidney
       Failure/PATHOLOGY/THERAPY/VIROLOGY  Male  Middle Age  Nephritis,
       Interstitial/PATHOLOGY/VIROLOGY  Prognosis  Treatment Outcome  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

