       Document 0957
 DOCN  M9620957
 TI    Multiorgan microsporidiosis: report of five cases and review.
 DT    9602
 AU    Gunnarsson G; Hurlbut D; DeGirolami PC; Federman M; Wanke C; Department
       of Medicine, New England Deaconess Hospital, Harvard; Medical School,
       Boston, Massachusetts, USA.
 SO    Clin Infect Dis. 1995 Jul;21(1):37-44. Unique Identifier : AIDSLINE
       MED/96065609
 AB    We describe five cases and review 34 reported cases of multiorgan
       microsporidiosis. Most of the patients with multiorgan involvement have
       been adults with AIDS. Organs most commonly infected include the small
       intestine, urinary tract, biliary tree, and eye; involvement of the
       respiratory tract, nasal sinuses, and central nervous system is also
       described but appears to be less frequent. Although patients with
       multiorgan disease may be asymptomatic, clinical presentation usually
       relates to the involved organs. Enterocytozoon bieneusi and Septata
       intestinalis are the most frequently identified species of pathogens. An
       affinity for certain tissues is observed among different microsporidial
       species. In all but one case of E. bieneusi infection, infection was
       limited to intestinal and hepatobiliary tracts, a finding suggestive of
       local extension. In contrast, the patients infected with S. intestinalis
       had widespread involvement, suggesting true hematogenous or lymphatic
       dissemination. Treatment may have to be based on findings regarding
       which organs and specific microsporidial species are involved. Further
       investigation of the pathogenic tendencies and route of acquisition of
       these organisms and the therapeutic agents active against them is
       needed.
 DE    Adult  Albendazole/THERAPEUTIC USE  Animal  Anthelmintics/THERAPEUTIC
       USE  AIDS-Related Opportunistic Infections/DRUG THERAPY/PATHOLOGY/
       *PARASITOLOGY  Biliary Tract Diseases/DRUG
       THERAPY/PATHOLOGY/PARASITOLOGY  Brain Diseases/DRUG
       THERAPY/PATHOLOGY/PARASITOLOGY  Case Report  Diarrhea/DRUG
       THERAPY/PATHOLOGY/PARASITOLOGY  Encephalitozoon/DRUG EFFECTS/ISOLATION &
       PURIF  Eye Infections, Parasitic/DRUG THERAPY/PATHOLOGY
       Feces/PARASITOLOGY  Human  Intestinal Diseases, Parasitic/DRUG
       THERAPY/PATHOLOGY  Lung Diseases, Parasitic/DRUG THERAPY/PATHOLOGY
       Macrophages/PARASITOLOGY  Male  Microspora Infections/DRUG
       THERAPY/PATHOLOGY/*PARASITOLOGY  Microsporida/DRUG EFFECTS/ISOLATION &
       PURIF  Middle Age  Paranasal Sinus Diseases/DRUG
       THERAPY/PATHOLOGY/PARASITOLOGY  Urinary Tract Infections/DRUG
       THERAPY/PATHOLOGY/PARASITOLOGY  Urine/PARASITOLOGY  JOURNAL ARTICLE
       REVIEW  REVIEW OF REPORTED CASES

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

