       Document 0736
 DOCN  M9620736
 TI    The inhibitory effect of the crude extract from a seaweed of Dygenea
       simplex C. Agardh on the in vitro cytopathic activity of HIV-1 and it's
       antigen production.
 DT    9602
 AU    Sekine H; Ohonuki N; Sadamasu K; Monma K; Kudoh Y; Nakamura H; Okada Y;
       Okuyama T; Department of Microbiology, Tokyo Metropolitan Research;
       Laboratory of Public Health, Japan.
 SO    Chem Pharm Bull (Tokyo). 1995 Sep;43(9):1580-4. Unique Identifier :
       AIDSLINE MED/96003369
 AB    The crude water extract (NS-1) from a seaweed (Digenea simplex C. Agardh
       Rhodomelaceae) exhibited anti-human immunodeficiency virus (HIV)-1
       activity in vitro. The inhibitory effect of the extract on the
       cytopathic activity of HIV-1 and it's antigen production was examined
       using a microplate method, immunofluorescent assay, and an HIV antigen
       detection kit (Abbott). NS-1 inhibited both the cytopathic effect of
       HIV-1 to MT-4 cells and the giant cell formation of Molt-4 cells
       infected with HIV-1.
 DE    Antiviral Agents/CHEMISTRY/*PHARMACOLOGY  Cell Line  Chemistry, Physical
       Cytopathogenic Effect, Viral/*DRUG EFFECTS  Fluorescent Antibody
       Technique, Indirect  Human  HIV Antigens/*BIOSYNTHESIS  HIV-1/*DRUG
       EFFECTS/IMMUNOLOGY  Molecular Weight  Plant
       Extracts/CHEMISTRY/*PHARMACOLOGY  T-Lymphocytes/IMMUNOLOGY/VIROLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

