       Document 0206
 DOCN  M9620206
 TI    Why disease due to Mycobacterium tuberculosis is less common than
       expected in HIV-positive patients in Edinburgh.
 DT    9602
 AU    Leitch AG; Rubilar M; Watt B; Laing R; Willcocks L; Brettle RP; Leen CL;
       Respiratory Medicine, Department of Medicine (RIE), University of;
       Edinburgh, U.K.
 SO    Respir Med. 1995 Aug;89(7):495-7. Unique Identifier : AIDSLINE
       MED/96048169
 AB    By December 1993, only five cases of tuberculosis were observed in the
       1030 HIV-positive patients in Edinburgh, U.K., although, on the basis of
       historical tuberculin skin test data, between four and eight new cases
       of tuberculosis were expected per year. Of 310 HIV-positive patients,
       none of the 19 (6.1%) who were tuberculin skin test positive had
       developed tuberculosis after 87 months (average) of follow-up. It is
       suggested that new or re-infection is a more common cause of
       tuberculosis in HIV-positive patients than reactivation. Restriction
       fragment length polymorphism typing of Mycobacterium tuberculosis
       strains could confirm this hypothesis and support currently suggested
       additional infection control procedures.
 DE    Adult  Follow-Up Studies  Human  HIV Infections/*COMPLICATIONS  Male
       Recurrence  Scotland/EPIDEMIOLOGY  Tuberculin Test
       Tuberculosis/COMPLICATIONS/*EPIDEMIOLOGY/MICROBIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

