       Document 0794
 DOCN  M9620794
 TI    Decreased expression of AMPA receptor messenger RNA and protein in AIDS:
       a model for HIV-associated neurotoxicity.
 DT    9602
 AU    Everall IP; Hudson L; al-Sarraj S; Honavar M; Lantos P; Kerwin R
 SO    Nat Med. 1995 Nov;1(11):1174-8. Unique Identifier : AIDSLINE
       MED/96071673
 AB    HIV infection can cause extensive neuronal loss and clinically a severe
       dementia. The cause of the neurotoxicity remains unclear as neurons are
       not infected, but disturbance of glutamate-linked calcium entry has been
       implicated. In this study, we have shown a decrease in HIV-infected
       brain of the expression of mRNA and protein of the GluR-A flop subtype
       of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)
       glutamate receptor in cerebellar Purkinje cells. Although Purkinje cells
       are relatively resistant to loss, the observed disturbance of AMPA
       receptors may contribute to the neurotoxic process in other vulnerable
       brain regions and clinically to the development of dementia.
 DE    Acquired Immunodeficiency Syndrome/*METABOLISM  Adult  Aged  AIDS
       Dementia Complex/ETIOLOGY/GENETICS/*METABOLISM  Human
       Immunohistochemistry  In Situ Hybridization  Male  Middle Age  Purkinje
       Cells/*METABOLISM  Receptors, AMPA/*BIOSYNTHESIS  RNA,
       Messenger/GENETICS/*METABOLISM  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

