       Document 0528
 DOCN  M9620528
 TI    Neuroantigen-specific Th2 cells are inefficient suppressors of
       experimental autoimmune encephalomyelitis induced by effector Th1 cells.
 DT    9602
 AU    Khoruts A; Miller SD; Jenkins MK; University of Minnesota Medical
       School, Department of; Microbiology, Minneapolis 55455.
 SO    J Immunol. 1995 Nov 15;155(10):5011-7. Unique Identifier : AIDSLINE
       MED/96062324
 AB    We have identified a method of polarizing polyclonal populations of
       activated T helper cells toward either the Th1 or Th2 phenotype using
       different short-term in vitro culture conditions. Since the Ag used was
       an encephalitogenic peptide for SJL/J mice, the pathogenic potential of
       these cell populations was tested in an adoptive transfer model of
       experimental autoimmune encephalomyelitis (EAE). Th1 cells reproducibly
       caused severe EAE, whereas highly polarized Th2 cells did not.
       Furthermore, highly polarized Th2 cells did not suppress EAE caused by
       Th1 cells. The anti-inflammatory cytokines made by Th2 cells may simply
       fail to inhibit tissue destruction mediated by differentiated Th1 cells
       at the effector phase of the disease. It is also possible that highly
       polarized Th2 cells may be inefficient at crossing the blood-brain
       barrier, which may limit their suppressive potential. In contrast,
       incompletely skewed T cell populations that produced high levels of both
       Th1 and Th2 cytokines were consistently only weakly encephalitogenic.
       Therefore, disease inhibition by Th2 cytokines may best be accomplished
       by intervention at earlier points preceding development of
       differentiated Th1 cells.
 DE    Animal  Cells, Cultured  Central Nervous System/IMMUNOLOGY  CD4-Positive
       T-Lymphocytes/*IMMUNOLOGY  Encephalomyelitis, Allergic/*IMMUNOLOGY
       Female  Immunosuppression  Immunotherapy  Mice  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  Th1 Cells/*IMMUNOLOGY  Th2
       Cells/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

