       Document 0620
 DOCN  M9620620
 TI    [The role of T-lymphocyte subsets in susceptibility and resistance to
       induction of autoimmunity in the central nervous system]
 DT    9602
 AU    Mostarica-Stojkovic M; Vukmanovic S; Radojkovic M; Ramic Z; Vuckovic S;
       Ejdus L; Pravica V; Simic MM; Lukic ML; Institute of Microbiology and
       Immunology, School of Medicine,; University of Belgrade.
 SO    Glas Srp Akad Nauka [Med]. 1994;(44):35-43. Unique Identifier : AIDSLINE
       MED/96021692
 AB    The importance of two major subsets of T cells (CD4 and CD8) for the
       induction of EAE was analysed in two strains of rats differing in
       susceptibility to EAE and the level of IL 2 production. It was found
       that CD8 cells do not play a role in the induction or in the inherent
       resistance to EAE. Additionally, the elimination of CD8 cells does not
       increase the IL 2 production in lymphoid cell cultures. Based on these
       and previous results showing that a low dose of cyclophosphamide readily
       abrogates the resistance to EAE and enhances the IL 2 production. Thus
       it was concluded that genetically determined differences in
       susceptibility to EAE are governed by immunoregulatory genes whose
       effect appears to be mediated at the level of cellular interaction of
       different subsets of CD4 T cells.
 DE    Animal  Central Nervous System/IMMUNOLOGY  CD4-CD8 Ratio  Disease
       Susceptibility/IMMUNOLOGY  Encephalomyelitis,
       Allergic/*IMMUNOLOGY/PHYSIOPATHOLOGY  English Abstract  Immunity
       Interleukin-2/BIOSYNTHESIS  Lymphocyte Transformation  Rats
       T-Lymphocyte Subsets/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

