       Document 0509
 DOCN  M9620509
 TI    Reduced capacity of antibodies from patients infected with human
       immunodeficiency virus type 1 (HIV-1) group O to neutralize primary
       isolates of HIV-1 group M viruses.
 DT    9602
 AU    Nyambi PN; Nkengasong J; Peeters M; Simon F; Eberle J; Janssens W;
       Fransen K; Willems B; Vereecken K; Heyndrickx L; et al; Institute of
       Tropical Medicine, Antwerp, Belgium.
 SO    J Infect Dis. 1995 Nov;172(5):1228-37. Unique Identifier : AIDSLINE
       MED/96036378
 AB    Neutralizing antibody patterns in sera of persons infected with human
       immunodeficiency virus type 1 (HIV-1) groups M and O to their homologous
       and heterologous primary isolates were determined in a peripheral blood
       mononuclear cell-based neutralization assay and correlated with their
       ability to bind to V3 loop synthetic peptides. Most HIV-1 group M sera
       (9/16) neutralized HIV-1 group O viruses, whereas fewer group O sera
       (3/13) only weakly neutralized HIV-1 group M viruses. Group M sera
       neutralizing HIV-1 group O viruses neutralized other HIV-1 group M
       viruses with titers of 1:10-1:1280. V3 loop binding capacity of sera did
       not reflect their neutralizing capacity of the homologous isolate.
       Despite the reduced neutralizing capacity of group O-infected patients'
       sera to group M viruses, some group M-infected patients' sera
       neutralized both HIV-1 group M and O isolates, suggesting that they
       share some conserved neutralizing epitopes.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/*IMMUNOLOGY  Amino Acid
       Sequence  Blotting, Western  Comparative Study  Enzyme-Linked
       Immunosorbent Assay  Epitopes/CHEMISTRY/*IMMUNOLOGY  Gene Products,
       env/GENETICS/*IMMUNOLOGY  Genes, env  Genes, gag  Human  HIV
       Antibodies/BLOOD/*IMMUNOLOGY
       HIV-1/*CLASSIFICATION/*IMMUNOLOGY/ISOLATION & PURIF
       Lymphocytes/*IMMUNOLOGY/VIROLOGY  Molecular Sequence Data
       Neutralization Tests  Peptide Fragments/CHEMISTRY/CHEMICAL
       SYNTHESIS/IMMUNOLOGY  Phylogeny  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

