       Document 0795
 DOCN  M9620795
 TI    Early suppression of SIV replication by CD8+ nef-specific cytotoxic T
       cells in vaccinated macaques.
 DT    9602
 AU    Gallimore A; Cranage M; Cook N; Almond N; Bootman J; Rud E; Silvera P;
       Dennis M; Corcoran T; Stott J; et al; Institute of Molecular Medicine,
       John Radcliffe Hospital, Oxford,; UK.
 SO    Nat Med. 1995 Nov;1(11):1167-73. Unique Identifier : AIDSLINE
       MED/96071672
 AB    In order to develop a successful subunit vaccine against infection with
       the human immunodeficiency virus (HIV), protective immune effector
       functions must be identified. Until now, there has been only indirect
       evidence that HIV-specific cytotoxic T lymphocytes (CTLs) fulfill this
       role. Using the macaque simian immunodeficiency virus (SIV) model, the
       protective potential of nef-specific CTLs, stimulated by vaccination,
       was examined in animals challenged with a high intravenous dose of the
       pathogenic simian immunodeficiency virus, SIVmac251(32H)(pJ5). An
       inverse correlation was found between the vaccine-induced nef-specific
       CTL precursor frequency and virus load measured after challenge. In
       addition, the early decline in viraemia, observed in both vaccinated and
       unvaccinated control animals was associated with the development of
       virus-specific CTL activity and not with the presence of virus-specific
       neutralizing antibodies. The results imply that vaccines that stimulate
       strong CTL responses could protect against HIV infection.
 DE    Animal  Cells, Cultured  DNA, Viral/BLOOD  Gene Products, gag/BLOOD
       Gene Products, nef/*IMMUNOLOGY  Leukocytes, Mononuclear/VIROLOGY  Macaca
       fascicularis  Polymerase Chain Reaction  Proviruses/GENETICS  Simian
       Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/VIROLOGY  Support,
       Non-U.S. Gov't  SIV/*PHYSIOLOGY  T-Lymphocytes, Cytotoxic/*IMMUNOLOGY
       *Vaccination  Vaccines, Synthetic  Viral Vaccines/*IMMUNOLOGY
       Viremia/PREVENTION & CONTROL  Virus Replication  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

