       Document 0734
 DOCN  M9620734
 TI    Components of biological variation in plasma haptoglobin: relationships
       to plasma fibrinogen and immune variables, including interleukin-6 and
       its receptor.
 DT    9602
 AU    Maes M; Cooreman W; Delanghe J; Scharpe S; Wauters A; Neels H; D'Hondt
       P; Peeters D; Cosyns P; Ranjan R; et al; Department of Psychiatry,
       University Hospitals of Cleveland,; Ohio, USA.
 SO    Clin Chim Acta. 1995 Jul 31;239(1):23-35. Unique Identifier : AIDSLINE
       MED/96051324
 AB    We investigated the components of biological variation, including
       seasonality, in plasma haptoglobin (Hp) levels and the relationships
       between plasma Hp and interleukin-6 (IL-6), soluble IL-6 receptor
       (sIL-6), sIL-2R, fibrinogen (Fb) and absolute number of peripheral blood
       mononuclear cells, such as leukocytes, neutrophils, monocytes,
       lymphocytes, CD4+, CD8+, CD25+ T cells and CD20+ B cells. Monthly blood
       samples were taken from 26 normal volunteers during one calendar year.
       The estimated inter- and intra-individual C.V. values for plasma Hp were
       27.9% and 20.0%, respectively; the index of individuality was 0.72. No
       significant seasonal rhythms could be detected in plasma Hp levels. The
       yearly mean values in plasma Hp were significantly and positively
       related to those in plasma Fb, absolute number of leukocytes,
       neutrophils, CD4+ T cells and the CD4+/CD8+ T cell ratio. 49.0% of the
       variance in the yearly mean values of plasma Hp could be explained by
       variances in serum IL-6 and number of CD4+ (positively related) and CD8+
       (negatively related) T cells. There were significant and positive time
       relationships between plasma Hp, on the one hand, and plasma Fb, sIL-6R,
       sIL-2R and number of leukocytes, neutrophils and monocytes, on the
       other. A smaller part of the within-subject variability in plasma Hp
       (i.e. 6.0%) could be explained by serum sIL-6R and sIL-2R. It is
       concluded that there are (1) important between-subject differences in
       the homeostatic setpoints of plasma Hp, which are related to those in
       plasma Fb and in immune status and (2) significant within-subject, time
       relationships between plasma Hp and indicators of immune activation and
       plasma Fb.
 DE    Adult  Aged  Antigens, CD/*METABOLISM  Comparative Study  CD4-CD8 Ratio
       Female  Fibrinogen/*METABOLISM  Haptoglobins/*METABOLISM  Human
       *Immunity  Interleukin-6/*METABOLISM  Leukocyte Count  Leukocytes,
       Mononuclear  Male  Middle Age  Monocytes  Neutrophils  Receptors,
       Interleukin/*METABOLISM  Seasons  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

