       Document 1062
 DOCN  M9621062
 TI    A community trial of the impact of improved sexually transmitted disease
       treatment on the HIV epidemic in rural Tanzania: 1. Design.
 DT    9602
 AU    Hayes R; Mosha F; Nicoll A; Grosskurth H; Newell J; Todd J; Killewo J;
       Rugemalila J; Mabey D; London School of Hygiene and Tropical Medicine,
       UK.
 SO    AIDS. 1995 Aug;9(8):919-26. Unique Identifier : AIDSLINE MED/96014967
 AB    OBJECTIVE: To describe the rationale and design of a randomized trial of
       the impact of improved services for the treatment of sexually
       transmitted diseases (STD) on the incidence of HIV infection in Mwanza
       Region, Tanzania. METHODS: The likely impact of improved STD treatment
       services on HIV incidence, and the need for empirical information on the
       effectiveness of this intervention strategy, are discussed. The
       rationale and design of such an intervention programme in Mwanza Region,
       and of a community-randomized trial to measure the impact of the
       programme on HIV and other STD, are presented. Problems in the design
       and interpretation of the trial are reviewed. RESULTS: Results of the
       baseline survey of the cohort of over 12,000 adults in 12 communities
       are presented in a companion paper. CONCLUSION: There is an urgent need
       for effective preventive measures against the HIV epidemic in
       sub-Saharan Africa and other developing regions. Improved STD treatment
       has been promoted as a potentially effective strategy, but there is
       little empirical information on its impact. The trial in Mwanza Region
       is the first randomized study of this intervention and should provide
       valuable data for health policy makers.
 DE    Adult  Algorithms  Community Health Services  Female  Human  HIV
       Infections/*EPIDEMIOLOGY/*PREVENTION & CONTROL  Male  Outcome Assessment
       (Health Care)  Prospective Studies  Randomized Controlled Trials/METHODS
       Rural Population  Sexually Transmitted Diseases/*THERAPY  Support,
       Non-U.S. Gov't  Tanzania/EPIDEMIOLOGY  CLINICAL TRIAL  JOURNAL ARTICLE
       RANDOMIZED CONTROLLED TRIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

