       Document 1063
 DOCN  M9621063
 TI    The incidence of complications after caesarean section in 156
       HIV-positive women.
 DT    9602
 AU    Semprini AE; Castagna C; Ravizza M; Fiore S; Savasi V; Muggiasca ML;
       Grossi E; Guerra B; Tibaldi C; Scaravelli G; et al; Department of
       Obstetrics and Gynaecology, San Paolo Biomedical; Institute, Milan,
       Italy.
 SO    AIDS. 1995 Aug;9(8):913-7. Unique Identifier : AIDSLINE MED/96014966
 AB    OBJECTIVE: To investigate the risks of post-operative complications in
       HIV-positive mothers who undergo a caesarean section (CS) because the
       delivery cannot be safely accomplished by the vaginal route or to
       protect the infant from viral infection. DESIGN: In a multicentre study,
       we reviewed the incidence and type of post-operative complications in
       156 HIV-positive women who underwent a CS. These results were compared
       with those observed in an equal number of HIV-uninfected women who
       matched for the indication requiring a caesarean delivery, the stage of
       labour, the integrity or rupture of membranes, and the use of antibiotic
       prophylaxis. SETTING: Seven teaching hospitals providing obstetrical
       care for mothers infected with HIV. RESULTS: We found that six
       HIV-infected mothers suffered a major complication (two cases of
       pneumonia, one pleural effusion, two severe anaemia and one sepsis)
       compared with only one HIV-negative woman who required blood transfusion
       after surgery. Minor complications like post-operative fever,
       endometritis, wound and urinary tract infections were significantly more
       frequent in HIV-positive women than controls. Multivariate analysis
       revealed that in HIV-infected women the only factor associated with a
       significant increase in the rate of complications was a CD4 lymphocyte
       count < 200 x 10(6)/l. CONCLUSIONS: The results of our study indicate
       that HIV-positive mothers are at an increased risk of post-operative
       complications when delivered by CS. The risk of post-operative
       complications is higher in HIV-infected women who are severely
       immunodepressed.
 DE    Case-Control Studies  Cesarean Section/*ADVERSE EFFECTS  CD4 Lymphocyte
       Count  Female  Human  HIV Infections/BLOOD/*COMPLICATIONS/IMMUNOLOGY
       Infant, Newborn  Postoperative Complications/*ETIOLOGY  Pregnancy
       Pregnancy Complications, Infectious/BLOOD/*ETIOLOGY/IMMUNOLOGY  Risk
       Factors  Support, Non-U.S. Gov't  JOURNAL ARTICLE  MULTICENTER STUDY

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

