       Document 0690
 DOCN  M9620690
 TI    Cytotoxic T lymphocytes and HIV-1 related neurologic disorders.
 DT    9602
 AU    Kalams SA; Walker BD; Infectious Disease Unit, Harvard Medical School,
       Boston, MA, USA.
 SO    Curr Top Microbiol Immunol. 1995;202:79-88. Unique Identifier : AIDSLINE
       MED/96004229
 AB    In summary, one can conclude that infected persons exhibit an extremely
       vigorous, virus-specific CTL response, and in at least some individuals
       this response is broadly directed at multiple epitopes. These cells are
       present at the time or initial control of viremia and can also be
       detected after more than a decade of asymptomatic infection. These cells
       can also be found in the central nervous system in persons with ADC, and
       one can envision pathways in which the inflammatory cytokines released
       by these cells upon activation could contribute to the neurologic
       sequelae of infection. However, the precise role of these cells as a
       protective host defense and the possible contribution of these cells, or
       products released by these cells, to tissue damage at sites such as the
       lung and brain remain to be determined. Further delineation of the role
       played by CTLs in the pathogenesis of disease should be extremely useful
       in helping to understand the disease itself and to guide intervention
       strategies.
 DE    AIDS Dementia Complex/*COMPLICATIONS/IMMUNOLOGY  Cytokines/PHYSIOLOGY
       Cytotoxicity, Immunologic  Human  HIV
       Infections/*COMPLICATIONS/IMMUNOLOGY  *HIV-1/IMMUNOLOGY  Peripheral
       Nervous System Diseases/*ETIOLOGY/IMMUNOLOGY/VIROLOGY  T-Lymphocyte
       Subsets/IMMUNOLOGY  T-Lymphocytes, Cytotoxic/*IMMUNOLOGY  JOURNAL
       ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

