       Document 1035
 DOCN  M9621035
 TI    Direct interaction of complement factor H with the C1 domain of HIV type
       1 glycoprotein 120.
 DT    9602
 AU    Pinter C; Siccardi AG; Longhi R; Clivio A; Dipartimento di Biologia e
       Genetica per le Scienze Mediche,; Universita di Milano, Milan, Italy.
 SO    AIDS Res Hum Retroviruses. 1995 May;11(5):577-88. Unique Identifier :
       AIDSLINE MED/96093893
 AB    A protein that binds specifically to Env 105-119 (HEDIISLWDQSLKPC) was
       found in pools of normal human plasma when this peptide was used in
       affinity chromatography procedures. These samples represented the
       negative control in experiments aimed at the purification of putative
       human antibodies to the Env 105-119 region from AIDS sera. In this
       article we describe the biochemical characterization of this protein,
       which turned out to be complement factor H (CFH). We propose a
       functional role for this protein in the complex, early steps of
       CD4-dependent HIV infection.
 DE    Amino Acid Sequence  Chromatography, Ion Exchange  Complement Factor
       H/ISOLATION & PURIF/*METABOLISM  Giant Cells/VIROLOGY  Human  HIV
       Antibodies/IMMUNOLOGY  HIV Envelope Protein gp120/IMMUNOLOGY/*METABOLISM
       HIV Envelope Protein gp41/METABOLISM  HIV-1/IMMUNOLOGY/*METABOLISM
       Molecular Sequence Data  Protein Binding  Receptors, HIV/METABOLISM
       Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

