       Document 1080
 DOCN  M9621080
 TI    Immunoglobulin-like domain of HIV-1 envelope glycoprotein gp120 encodes
       putative internal image of some common human proteins.
 DT    9602
 AU    Metlas R; Skerl V; Veljkovic V; Colombatti A; Pongor S; Laboratory for
       Multidisciplinary Research, Institute for Nuclear; Sciences Vinca,
       Belgrade, Yugoslavia.
 SO    Viral Immunol. 1994;7(4):215-9. Unique Identifier : AIDSLINE
       MED/96100716
 AB    By examining sequence similarity between the V3-loop of gp120 from
       various HIV-1 isolates and human proteins, we found that the V3 loop
       portion KKGIAIGPGR in strain New York 5 (HIV-1NY5) shares 70% identical
       residues with the collagen-like region (CLR) of human complement
       component C1q-A. C1q CLR was found to react with autoantibodies from
       several autoimmune disorders. Thus, we assumed that it would be of
       interest to find out the C1q reactivity with antibodies from AIDS sera.
       The results obtained show that the V3 loop-derived synthetic peptide
       KKGIAIGPGRTLY reacts both with AIDS patients sera and with antibodies
       purified on the V3 loop peptide-affinity column. The same
       affinity-purified antibodies bind also to C1q molecules. Since,
       according to our previous results, HIV-1 V3 loops and immunoglobulin
       heavy chain variable regions (Ig VH) share several common features, we
       suggest that the envelope of HIV-1NY5 bears a functional internal image
       of the C1q-A CLR epitope. Therefore, gp120 could manipulate the immune
       network and contribute to HIV-induced autoimmunity.
 DE    Amino Acid Sequence  Antibodies, Anti-Idiotypic/ANALYSIS/*GENETICS
       Complement 1q/*GENETICS/IMMUNOLOGY  Human  HIV Envelope Protein
       gp120/ANALYSIS/*GENETICS/IMMUNOLOGY  HIV-1/*IMMUNOLOGY  Immunoglobulin
       Variable Region/GENETICS  Immunoglobulins, Heavy-Chain/GENETICS
       Molecular Sequence Data  Peptide Fragments/ANALYSIS/*GENETICS  Sequence
       Homology, Amino Acid  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

