       Document 0245
 DOCN  M9620245
 TI    Morphological changes of thymus in retrovirus-induced murine acquired
       immunodeficiency syndrome (MAIDS).
 DT    9602
 AU    de Leval L; Deprez M; Colombi S; Humblet C; Defresne MP; Boniver J;
       Moutschen M; Laboratory of Pathology, University of Liege, Belgium.
 SO    Pathol Res Pract. 1995 Jul;191(6):506-12. Unique Identifier : AIDSLINE
       MED/96053119
 AB    The possible contribution of the thymus in the setting of acquired
       immunodeficiencies is still questioned. Here we report some new findings
       regarding a potential involvement of the thymus in mice infected with
       RadLV-Rs, a viral mixture inducing murine acquired immunodeficiency
       syndrome (MAIDS). Thymi were sequentially removed, weighted and
       morphologically analyzed at different time intervals post-infection.
       Infection with RadLV-Rs led to a decrease in thymus weight mostly
       apparent from the fourth week. The first changes were seen at the third
       week as perivascular clusters of B-cells at the cortico-medullary
       junction. The ensuing process of atrophy mainly involved the cortex,
       while a mixed population of large T- and B-cells filled the medulla.
       These observations are discussed with regard to the pathological changes
       occurring in other lymphoid and non-lymphoid organs, in the context of
       the lymphoproliferation and immunodeficiency characterizing the disease,
       and by comparison with other models of retrovirus-induced
       immunodeficiencies.
 DE    Animal  Atrophy/PATHOLOGY  Disease Models, Animal  Male  Mice  Mice,
       Inbred C57BL  Murine Acquired Immunodeficiency Syndrome/*PATHOLOGY
       Organ Weight  Retroviridae  Support, Non-U.S. Gov't  Thymus
       Gland/*PATHOLOGY  Time Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

