       Document 0115
 DOCN  M9620115
 TI    HTLV-I from Iranian Mashhadi Jews in Israel is phylogenetically related
       to that of Japan, India, and South America rather than to that of Africa
       and Melanesia.
 DT    9602
 AU    Yamashita M; Achiron A; Miura T; Takehisa J; Ido E; Igarashi T; Ibuki K;
       Osame M; Sonoda S; Melamed E; et al; Laboratory of Pathogenic Virus,
       Kyoto University, Japan.
 SO    Virus Genes. 1995;10(1):85-90. Unique Identifier : AIDSLINE
       GENBANK/D38403
 AB    A new endemic focus of human T-lymphotropic virus type I (HTLV-I) was
       recently reported among Mashhadi Jews, a group of immigrants from
       northeastern Iran to Israel. We extracted DNAs from fresh peripheral
       blood mononuclear cells (PBMCs) and/or gargle mouthwash from 10 HTLV-I
       carriers, who consisted of members of one family, and HTLV-I-associated
       myelopathy (HAM) and adult T-cell leukemia (ATL) patients. Long terminal
       repeat (LTR) regions of proviral DNAs were sequenced and analyzed
       phylogenetically. In a phylogenetic tree, all the Mashhadi HTLV-I
       isolates belonged to subtype A, one of the three subtypes of the
       cosmopolitan type of HTLV-I, and made a tight cluster distinct from the
       other isolates of subtype A from Japan, India, the Caribbean Basin, and
       South America. Although a few nucleotide substitutions were observed
       among the clones sequenced, no characteristic sequence variation was
       found in different disease manifestations, even in one family or
       different sources of DNA preparation.
 DE    Adult  Africa  Aged  Base Sequence  Carrier State  DNA, Viral  Female
       Human  HTLV-I/*CLASSIFICATION/ISOLATION & PURIF  HTLV-I
       Infections/BLOOD/*VIROLOGY  India  Iran  Israel  Japan  Jews  Leukemia,
       T-Cell/BLOOD/VIROLOGY  Leukocytes, Mononuclear/VIROLOGY  Male  Melanesia
       Middle Age  Molecular Sequence Data  Paraparesis, Tropical
       Spastic/BLOOD/VIROLOGY  Phylogeny  South America  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

