       Document 0279
 DOCN  M9620279
 TI    Follicular dendritic cells and human immunodeficiency virus infectivity
       [see comments]
 DT    9602
 AU    Heath SL; Tew JG; Tew JG; Szakal AK; Burton GF; Department of
       Microbiology & Immunology, Virginia Commonwealth; University, Richmond
       23298-0678, USA.
 SO    Nature. 1995 Oct 26;377(6551):740-4. Unique Identifier : AIDSLINE
       MED/96042553
 CM    Comment in: Nature 1995 Oct 26;377(6551):680-1
 AB    Large amounts of human immunodeficiency virus (HIV) localize on
       follicular dendritic cells (FDC) in the follicles of secondary lymphoid
       tissues following viral infection. During clinical latency, active viral
       infection occurs primarily at these sites. As HIV on FDC is in the form
       of immune complexes, some of which may be formed with neutralizing
       antibody, we investigated whether HIV on FDC is infectious. We report
       here that HIV on FDC is highly infectious. Furthermore, FDC can convert
       neutralized HIV into an infectious form even in the presence of a vast
       excess of neutralizing antibody. Thus FDC may provide a mechanism
       whereby HIV infection can continue in the presence of neutralizing
       antibody.
 DE    Animal  Antibodies, Monoclonal/IMMUNOLOGY  Cells, Cultured  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY/VIROLOGY  Dendritic Cells/IMMUNOLOGY/*VIROLOGY
       Human  HIV Antibodies/IMMUNOLOGY  HIV Infections/IMMUNOLOGY/*VIROLOGY
       HIV-1/IMMUNOLOGY/*PATHOGENICITY  Mice  Neutralization Tests  Support,
       U.S. Gov't, P.H.S.  Tonsil/IMMUNOLOGY/*VIROLOGY  Virus Replication
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

