       Document 0890
 DOCN  M9620890
 TI    The CD4+ T-cell network and the cytokine profile after HIV-1 infection.
 DT    9602
 AU    Caterino-de-Araujo A; Secao de Imunologia, Instituto Adolfo Lutz, Sao
       Paulo, Brasil.
 SO    Braz J Med Biol Res. 1995 Jan;28(1):2-6. Unique Identifier : AIDSLINE
       MED/96059246
 AB    The present article discusses CD4+ T-cell interaction and cytokine
       production after HIV-1 infection and progression to AIDS. On the basis
       of the experience of the author with biological fluids obtained from
       patients suspected of having AIDS and the recently available data
       concerning this matter, a model is proposed for the CD4+ T-cells network
       and CD4+ T-cells destruction during this infection. The mechanism of
       cellular killing involves apoptosis and preferential destruction of
       activated TH0/TH2-type cells. This type of cells is generated as an
       immune response to HIV-1 itself or to allergens and helminth
       infestations. The virus replicates more effectively in activated
       TH0/TH2-type cells and this contributes to the development of full-blown
       AIDS. The author has previously proposed the hypothesis of an elevation
       in IL-5 production during later stages of the disease and the use of
       eosinophilia of unknown etiology as a prognostic marker of AIDS in
       developing countries (Caterino-de-Araujo (1994). Immunology Today, 15:
       498-499). At the present time, this proposition is confirmed and the use
       of eosinophilia as an indicator of a shift to a TH0/TH2-type response
       that predicts progression to AIDS is justified.
 DE    Acquired Immunodeficiency Syndrome/*PATHOLOGY  Apoptosis/*PHYSIOLOGY
       Cytokines/*BIOSYNTHESIS  CD4-Positive T-Lymphocytes/*PATHOLOGY
       Eosinophilia/DIAGNOSIS  Human  Interleukin-5/BIOSYNTHESIS  Th2
       Cells/*PHYSIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

