       Document 0682
 DOCN  M9620682
 TI    Evidence of a selective depletion of a CD16+ CD56+ CD8+ natural killer
       cell subset during HIV infection.
 DT    9602
 AU    Lucia B; Jennings C; Cauda R; Ortona L; Landay AL; Instituto di Clinica
       delle Malattie Infettive Universita; Cattolica S. Cuore Largo A.
       Gemelli, Roma, Italy.
 SO    Cytometry. 1995 Mar 15;22(1):10-5. Unique Identifier : AIDSLINE
       MED/96090276
 AB    Three-color flow cytometric analysis of CD16+ natural killer (NK) cells
       was assessed in HIV seropositive patients and healthy heterosexual
       controls. A selective depletion of lymphocytes with the CD16+ NK
       phenotype was found among the HIV+ infected patients. When the CD16
       lymphocyte subset was further evaluated by three-color flow cytometry,
       cells bearing both the CD8 and CD56 antigens were significantly
       decreased. Analysis of activation antigens revealed a large proportion
       of CD16+ NK cells from HIV+ patients expressed HLA-DR, but this did not
       correlate with CD25 (IL-2 receptor) expression. The overall loss of the
       CD8 and CD56 antigens among the NK population with an increase in
       activation status may be due to differential loss of the NK cell subsets
       or, alternatively, to the loss of immunoregulatory cytokines, which have
       been shown to be important in maintaining NK activity. Whether these
       changes in the NK compartment may influence the outcome of individuals
       with HIV disease still remains an open question but is an important
       issue when performing phenotypic analysis of HIV+ subjects.
 DE    Case-Control Studies  Color  CD4 Lymphocyte Count  CD8-Positive
       T-Lymphocytes/*IMMUNOLOGY  Evaluation Studies  Flow Cytometry/*METHODS
       Human  HIV Infections/*IMMUNOLOGY  HIV Seropositivity/IMMUNOLOGY
       Immunophenotyping  Killer Cells, Natural/*IMMUNOLOGY  Lymphocyte Count
       Lymphocyte Subsets/*IMMUNOLOGY  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

