       Document 0292
 DOCN  M9620292
 TI    Torsade de pointes and elevated magnesium and calcium requirements
       associated with intravenous pentamidine.
 DT    9602
 AU    Olree K; Stein-Gocken J
 SO    Nutr Clin Pract. 1994 Oct;9(5):191-5. Unique Identifier : AIDSLINE
       MED/96037612
 AB    We present a report of markedly elevated calcium and magnesium
       requirements in an AIDS patient receiving central venous nutrition.
       These increased requirements were attributed to urinary magnesium losses
       associated with intravenous pentamidine therapy. The combination of
       intravenous pentamidine and electrolyte abnormalities resulted in the
       development of the dysrhythmia, torsade de pointes, in the patient. A
       review of literature presenting similar cases is included. Nutrition
       practitioners should be aware of the often prolonged effect of
       intravenous pentamidine on magnesium and calcium homeostasis so that
       adequate supplementation will be provided, perhaps preventing the
       development of life-threatening torsade de pointes.
 DE    Adult  AIDS-Related Opportunistic Infections/DRUG THERAPY  Case Report
       Electrocardiography  Human  Hypocalcemia/*CHEMICALLY INDUCED  Infusions,
       Intravenous  Magnesium Deficiency/BLOOD/*CHEMICALLY INDUCED  Male
       Nutritional Support  Pentamidine/*ADVERSE EFFECTS  Pneumonia,
       Pneumocystis carinii/DRUG THERAPY  Torsades de Pointes/*CHEMICALLY
       INDUCED  JOURNAL ARTICLE  REVIEW  REVIEW OF REPORTED CASES

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

