       Document 0057
 DOCN  M9620057
 TI    Risk factors for HIV-1 seroconversion among injection drug users: a
       case-control study.
 DT    9602
 AU    Chitwood DD; Griffin DK; Comerford M; Page JB; Trapido EJ; Lai S; McCoy
       CB; Comprehensive Drug Research Center, University of Miami School of;
       Medicine, FL 33136, USA.
 SO    Am J Public Health. 1995 Nov;85(11):1538-42. Unique Identifier :
       AIDSLINE MED/96036584
 AB    OBJECTIVES. A nested case-control study was conducted in Miami, Fla, to
       determine risk factors associated with human immunodeficiency virus type
       1 (HIV-1) seroconversion among injection drug users. METHODS. The study
       identified 21 incident cases of HIV-1 infection and 76 unmatched
       controls from two longitudinal cohorts of injection drug users. One
       cohort consisted of individuals who originally had been recruited from
       treatment centers; a second cohort was recruited from the street.
       Logistic regression analyses that adjusted for age, gender, and race
       were performed. RESULTS. The final model determined that the primary
       independent risk factor that best explained the risk for seroconversion
       was sharing injection equipment in the year prior to conversion; a
       marginal risk factor was presence of sexually transmitted disease during
       this same period. CONCLUSIONS. Both an injection component and a sexual
       component play a role in seroconversion among injection drug users,
       although the injection component is much stronger.
 DE    Adult  Age Factors  Case-Control Studies  Cohort Studies  Female
       Florida/EPIDEMIOLOGY  Human  HIV
       Seropositivity/COMPLICATIONS/*EPIDEMIOLOGY  Male  *Needle Sharing
       Questionnaires  Risk Factors  Sex Behavior  Sex Factors  Substance
       Abuse, Intravenous/*COMPLICATIONS  Support, U.S. Gov't, P.H.S.  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

