       Document 0105
 DOCN  M9620105
 TI    The simian immunodeficiency virus transmembrane protein is poorly
       immunogenic in inactivated virus vaccine.
 DT    9602
 AU    Cranage MP; McBride BW; Rud EW; Centre for Applied Microbiology and
       Research, Porton Down,; Salisbury, UK.
 SO    Vaccine. 1995 Jul;13(10):895-900. Unique Identifier : AIDSLINE
       MED/96021573
 AB    The transmembrane proteins (TMP) of immunodeficiency lentiviruses are
       primary candidates for inclusion in AIDS vaccines, the design and
       testing of which is facilitated by the SIV-macaque infection model.
       Antibody responses to linear determinants in the SIVmac TMP were
       investigated in rhesus macaques either infected with the SIVmac J5
       molecular clone or vaccinated with partially purified,
       formalin-inactivated SIVmac. Infected animals were shown to recognise
       predominantly four regions in the external domain and three regions in
       the internal domain of the TMP defined by a series of nominally 20mer
       overlapping peptides. In contrast SIV vaccinates had extremely
       restricted and weak antibody responses to the TMP, indicating a
       selective loss of immunogenicity of this component in the vaccine.
 DE    Amino Acid Sequence  Animal  Antibodies, Viral/BIOSYNTHESIS
       Epitopes/IMMUNOLOGY  Gene Products, env/*IMMUNOLOGY  Macaca mulatta
       Molecular Sequence Data  Retroviridae Proteins, Oncogenic/*IMMUNOLOGY
       Simian Acquired Immunodeficiency Syndrome/PREVENTION & CONTROL  Support,
       Non-U.S. Gov't  SAIDS Vaccines/*IMMUNOLOGY  SIV/*IMMUNOLOGY  Vaccines,
       Inactivated/IMMUNOLOGY  Viral Fusion Proteins/*IMMUNOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

