       Document 0025
 DOCN  M9620025
 TI    Inhibition of visna virus replication and cytopathic effect in sheep
       choroid plexus cell cultures by selected anti-HIV agents.
 DT    9602
 AU    Thormar H; Balzarini J; Debyser Z; Witvrouw M; Desmyter J; De Clercq E;
       Institute of Biology, University of Iceland, Reykjavik.
 SO    Antiviral Res. 1995 May;27(1-2):49-57. Unique Identifier : AIDSLINE
       MED/96075694
 AB    Several anti-HIV agents were tested against visna virus replication and
       cytopathic effect (CPE) in sheep choroid plexus cell cultures. Sulphated
       polysaccharides (i.e., dextran sulphate, pentosan polysulphate and
       heparin) and plant lectins, which inhibit viral adsorption and fusion,
       were found to be 10- to 40-fold less active against visna virus than
       against HIV. Bicyclam derivatives were at least 250-fold less active
       against visna virus and the highly HIV-1 specific TIBO derivatives were
       without a significant inhibitory effect on visna virus at subtoxic
       concentrations. In contrast, several 2',3'-dideoxynucleosides and
       acyclic nucleoside phosphonate analogues, which inhibit reverse
       transcription, were found to be very effective inhibitors of visna virus
       replication and viral CPE in cell culture.
 DE    Animal  Antiviral Agents/*PHARMACOLOGY  Benzodiazepinones/PHARMACOLOGY
       Cattle  Cells, Cultured  Choroid Plexus/CYTOLOGY  Cytopathogenic Effect,
       Viral/DRUG EFFECTS  HIV-1  Lectins/PHARMACOLOGY  Pyrroles/PHARMACOLOGY
       Reverse Transcriptase Inhibitors/PHARMACOLOGY  Sheep  Support, Non-U.S.
       Gov't  Virus Replication/*DRUG EFFECTS  Visna-Maedi Virus/*DRUG
       EFFECTS/PHYSIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

