       Document 0748
 DOCN  M9620748
 TI    Regression of established tumors in mice mediated by the oral
       administration of a recombinant Listeria monocytogenes vaccine.
 DT    9602
 AU    Pan ZK; Ikonomidis G; Pardoll D; Paterson Y; Department of Microbiology,
       University of Pennsylvania,; Philadelphia 19104-6076, USA.
 SO    Cancer Res. 1995 Nov 1;55(21):4776-9. Unique Identifier : AIDSLINE
       MED/96046570
 AB    We have shown previously that Listeria monocytogenes, a gram-positive,
       facultative intracellular bacterium, is a potent vector for targeting
       tumor-specific antigens to the immune system. After parenteral
       administration, we observed protection against both renal and colorectal
       mouse tumors and regression of established renal tumors. In the present
       study, we have exploited the fact that the normal route of infection of
       this organism is through the gut. We show that an L. monocytogenes
       recombinant that expresses a model tumor antigen is an effective cancer
       immunotherapeutic agent when delivered orally in that it causes
       regression of established, macroscopic mouse renal and colorectal tumors
       expressing the same antigen.
 DE    Administration, Oral  Animal  Antigens, Neoplasm/IMMUNOLOGY  Antigens,
       Viral/GENETICS/IMMUNOLOGY  Bacterial Vaccines/*THERAPEUTIC USE
       Carcinoma, Renal Cell/IMMUNOLOGY/THERAPY  Colonic
       Neoplasms/IMMUNOLOGY/THERAPY  Gene Products, gag/METABOLISM
       Immunotherapy, Active  Kidney Neoplasms/IMMUNOLOGY/THERAPY  Listeria
       monocytogenes/GENETICS/*IMMUNOLOGY  Melanoma, Experimental/THERAPY  Mice
       Mice, Inbred BALB C  Mice, Inbred C57BL  Neoplasms,
       Experimental/IMMUNOLOGY/*THERAPY  Nucleoproteins/IMMUNOLOGY  Recombinant
       Proteins/GENETICS/IMMUNOLOGY  Support, Non-U.S. Gov't  Support, U.S.
       Gov't, P.H.S.  T-Lymphocytes, Cytotoxic/IMMUNOLOGY  Transduction,
       Genetic  Tumor Cells, Cultured  Vaccines, Synthetic/*THERAPEUTIC USE
       Viral Core Proteins/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

