       Document 0639
 DOCN  M9620639
 TI    Down-modulation of CD4+ T helper type 2 and type 0 cells by T helper
       type 1 cells via Fas/Fas-ligand interaction.
 DT    9602
 AU    Hahn S; Stalder T; Wernli M; Burgin D; Tschopp J; Nagata S; Erb P;
       Institute for Medical Microbiology, University of Basel,; Switzerland.
 SO    Eur J Immunol. 1995 Sep;25(9):2679-85. Unique Identifier : AIDSLINE
       MED/96011886
 AB    Fas was recently demonstrated to be the major target molecule engaged by
       CD4+ cytolytic T lymphocytes (CTL). We examined Fas expression on
       various cloned T cell subpopulations and their susceptibility to lysis
       by CD4+ or CD8+ CTL. A reciprocal relationship in Fas and Fas-ligand
       expression was observed in CD4+ T helper (Th)1- and Th2-type clones, and
       Fas mRNA was predominantly detected in Th2 clones, whereas Fas-ligand
       mRNA was principally found in Th1 clones. The two Th0 clones tested
       expressed both Fas and Fas-ligand, but only one exhibited cytolytic
       activity, whereas both were sensitive to CD4-mediated lysis. A
       functional consequence of the inverse Fas-Fas-ligand expression pattern
       was that Th2 and Th0 cells were sensitive to lysis by both Th1 CD4+ CTL
       and a CD8+ CTL clone in a Fas-dependent manner. These results suggest
       that cytolytic CD4+ Th1 cells may play an immunomodulatory role,
       regulating a Th2/Th0 response by Fas-mediated lysis.
 DE    Animal  Antigens, CD4/*BIOSYNTHESIS  Antigens, CD95/*IMMUNOLOGY  Base
       Sequence  Cell Communication  Cells, Cultured  Down-Regulation
       (Physiology)  Ligands  Mice  Molecular Sequence Data  RNA,
       Messenger/ANALYSIS  Support, Non-U.S. Gov't  T-Lymphocyte
       Subsets/IMMUNOLOGY  Th1 Cells/*IMMUNOLOGY/METABOLISM  Th2
       Cells/*IMMUNOLOGY/METABOLISM  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

