       Document 0521
 DOCN  M9620521
 TI    Evidence for immunologic immaturity of cord blood T cells. Cord blood T
       cells are susceptible to tolerance induction to in vitro stimulation
       with a superantigen.
 DT    9602
 AU    Takahashi N; Imanishi K; Nishida H; Uchiyama T; Department of
       Microbiology and Immunology, Tokyo Women's Medical; College, Japan.
 SO    J Immunol. 1995 Dec 1;155(11):5213-9. Unique Identifier : AIDSLINE
       MED/96072795
 AB    T cell blasts resulting from stimulating human cord blood (CB)
       mononuclear cells (MC) and adult peripheral blood (APB) MC with a
       bacterial superantigen, toxic shock syndrome toxin-1 (TSST-1), and then
       with human rIL-2 were investigated for their reactions to restimulation
       with TSST-1. Expression of TCR V beta 2, which determines the potential
       reactivity to TSST-1 and of CD45RO, was increased in both TSST-1-induced
       CB and APB T cell blasts. Most preparations of the TSST-1-induced CB T
       cell blasts exhibited low or no production of IL-2 and IL-4 in response
       to restimulation with TSST-1, while the APB T cell blasts showed high
       responses. TSST-1-induced T cell blasts derived from APB T cells
       depleted of both CD45RO+ T cells and HLA class II+ T cells showed high
       IL-2 production in response to restimulation with TSST-1. TSST-1-induced
       CB T cell blasts generated in the presence of DR+ L cells with high
       accessory cell activity still showed a low response to restimulation
       with TSST-1. These results indicate that CB T cells are inherently
       highly susceptible to tolerance induction by bacterial superantigens,
       suggesting the immunologic immaturity of CB T cells.
 DE    Adult  Aging/IMMUNOLOGY  Cell Differentiation  Cells, Cultured
       Cytokines/BIOSYNTHESIS  CD4-Positive T-Lymphocytes/*IMMUNOLOGY
       Enterotoxins/*IMMUNOLOGY  Fetal Blood/*IMMUNOLOGY  Human  Immune
       Tolerance/*IMMUNOLOGY  Infant, Newborn  Interleukin-2/BIOSYNTHESIS
       Superantigens/IMMUNOLOGY  Support, Non-U.S. Gov't  Th2 Cells/IMMUNOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

