       Document 0698
 DOCN  M9620698
 TI    Feline immunodeficiency virus as a model for study of lentivirus
       infection of the central nervous system.
 DT    9602
 AU    Henriksen SJ; Prospero-Garcia O; Phillips TR; Fox HS; Bloom FE; Elder
       JH; Department of Neuropharmacology, Scripps Research Institute, La;
       Jolla, C 92037, USA.
 SO    Curr Top Microbiol Immunol. 1995;202:167-86. Unique Identifier :
       AIDSLINE MED/96004235
 AB    Feline immunodeficiency virus infects the CNS and results in predictable
       pathophysiology strikingly similar to that seen with HIV-1 infection of
       humans. The observed pathophysiology is mimicked in several
       physiologically assessed modalities, further supporting the validity of
       the feline model. Peripheral and control evoked potential findings and
       the occurrence of the sleep architecture changes in both cat and human
       disease provide an intriguing focus for further investigation. Although
       structurally diverse in an absolute sense, FIV and HIV-1 share basic
       structural features and commonalities of their life cycle. It is likely
       that by understanding the common mechanisms by which these lentiviruses
       influence CNS function, a more complete understanding of the
       neurological deficits seen in HIV-1 infected patients will be obtained.
       The cat model is particularly valuable for study of CNS disease, since
       it allows detailed analyses of events during the acute phase of
       infection, under circumstances in which the nature and timing of the
       infection are carefully controlled. The availability of molecular clones
       for mutational analysis will facilitate mapping of genomic regions
       critical to the perturbation of CNS function. It is suggested that
       development of intervention strategies in the cat model will yield
       treatment modalities directly applicable to HIV-1 infection of humans.
 DE    Animal  *AIDS Dementia Complex  Behavior, Animal  Brain/PATHOLOGY  Cat
       Diseases/PATHOLOGY/VIROLOGY  Cats  Cerebrospinal Fluid/VIROLOGY
       Comparative Study  *Disease Models, Animal
       Encephalitis/PATHOLOGY/*VETERINARY/VIROLOGY  *Feline Acquired
       Immunodeficiency Syndrome/PATHOLOGY/VIROLOGY  Genome, Viral  Human
       HIV-1/GENETICS  *Immunodeficiency Virus, Feline/GENETICS  Peripheral
       Nervous System Diseases/PATHOLOGY/VETERINARY/VIROLOGY  Rats  Sleep
       Disorders/PATHOLOGY/VETERINARY/VIROLOGY  Species Specificity  Support,
       U.S. Gov't, P.H.S.  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

