       Document 0135
 DOCN  M9620135
 TI    Increased serum concentration of soluble HLA-DR antigens in HIV
       infection and following transplantation.
 DT    9602
 AU    Filaci G; Contini P; Brenci S; Lanza L; Scudeletti M; Indiveri F; Puppo
       F; Department of Internal Medicine, University of Genova, Italy.
 SO    Tissue Antigens. 1995 Aug;46(2):117-23. Unique Identifier : AIDSLINE
       MED/96100800
 AB    HLA class I and class II antigens circulate in serum as soluble
       molecules. Increased concentrations of soluble HLA class I molecules
       have been demonstrated in viral diseases, in rejection episodes
       following organ transplantation and in graft versus host disease. To
       explore the possibility of a variation of the serum concentrations of
       soluble HLA class II molecules in the same pathologic conditions we
       developed a double determinant immune assay that detects whole soluble
       HLA-DR molecules (sHLA-DR). The mean level of sHLA-DR antigens in sera
       from 23 healthy individuals was 0.64 +/- 0.72 microgram/ml. Elevated
       serum concentrations of sHLA-DR molecules were detected in sera from HIV
       infected patients in CDC2/3 and in CDC4 C1 stages (2.0 +/- 1.7
       micrograms/ml and 4.6 +/- 1.7 micrograms/ml, respectively), in sera from
       patients affected by acute rejection after liver transplantation (5.3
       +/- 3.7 micrograms/ml) and in sera from patients affected by severe
       acute graft versus host disease following bone marrow transplantation
       (8.8 +/- 3.1 micrograms/ml). The increase of sHLA-DR molecules in these
       sera significantly correlated with the elevation of soluble HLA class I
       antigens (P = 0.0004). The reported data suggest that both soluble HLA
       class I and class II molecules serum levels increase during viral
       infections and strong immune reactions and could suggest the involvement
       of these molecules in immunoregulation.
 DE    Bone Marrow Transplantation/IMMUNOLOGY  Graft vs Host
       Disease/BLOOD/ETIOLOGY  Graft Rejection/BLOOD/ETIOLOGY
       Histocompatibility Antigens Class I/BLOOD  Histocompatibility Antigens
       Class II/BLOOD  Human  HIV Infections/BLOOD/COMPLICATIONS/*IMMUNOLOGY
       HLA-DR Antigens/*BLOOD  Immunoassay/STANDARDS  Intercellular Adhesion
       Molecule-1/BLOOD  *Liver Transplantation  Sensitivity and Specificity
       Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

