       Document 0654
 DOCN  M9620654
 TI    Association between HIV and other DNA viruses in vitro.
 DT    9602
 AU    Cisterna R; Campelo C; Gorrino T; Malave C; Sarria L; Lardelli P;
       Fernandez de Aranguiz A; Madariaga L; Immunology, Microbiology and
       Parasitology Department, University; of Basque Country, Bilbao, Spain.
 SO    Eur J Clin Microbiol Infect Dis. 1995 Jul;14(7):591-6. Unique Identifier
       : AIDSLINE MED/96047084
 AB    To investigate the association of human immunodeficiency virus (HIV)
       with various DNA viruses, including hepatitis B virus (HBV),
       cytomegalovirus (CMV) and Epstein-Barr virus, (EBV), simultaneous
       detection of HIV p24 antigen, HBV surface antigen and DNA, CMV-DNA and
       EBV-DNA expression was performed in phytohemagglutinin-stimulated
       peripheral blood mononuclear (PBMC) culture supernatants obtained from
       54 individuals at risk for HIV infection. HIV expression in PBMC culture
       supernatants never occurred alone; expression of other viruses was
       always detected in the 24 samples expressing HIV antigen in vitro.
       Furthermore, in 16 patients expression of other viruses was detected
       without HIV expression, and in 14 patients none of the tested viruses
       were detected. These results indicate a strong association between the
       presence of HIV antibody and expression of DNA viruses in vitro (p =
       0.0001). The coexpression of these viruses could be related to the
       evolution of HIV infection and AIDS.
 DE    Cells, Cultured  Cytomegalovirus/GENETICS/IMMUNOLOGY/*ISOLATION & PURIF
       DNA, Viral/ANALYSIS  Hepatitis B Virus/GENETICS/IMMUNOLOGY/*ISOLATION &
       PURIF  Herpesvirus 4, Human/GENETICS/IMMUNOLOGY/*ISOLATION & PURIF
       Human  HIV Core Protein p24/ANALYSIS  HIV Infections/*VIROLOGY
       Leukocytes, Mononuclear/VIROLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

