       Document 0808
 DOCN  M9620808
 TI    Interleukin-10 and its receptor.
 DT    9602
 AU    Ho AS; Moore KW; Department of Immunology, DNAX Research Institute of
       Molecular; and Cellular Biology, Palo Alto, CA 94306, USA.
 SO    Ther Immunol. 1994 Jun;1(3):173-85. Unique Identifier : AIDSLINE
       MED/96053301
 AB    The cytokine interleukin-10 (IL-10) has several important activities on
       cells of the immune system. IL-10 profoundly suppresses activation of
       macrophages, inhibiting their ability to secrete cytokines and serve as
       accessory cells for stimulation of T cell and natural killer (NK) cell
       function. IL-10 also plays a role in stimulating proliferation and
       differentiation of B cells, mast cells, and both mature and immature T
       cells. At least two herpesviruses harbor analogs of the IL-10 gene; the
       Epstein-Barr virus (EBV) homolog (BCRF1, viral IL-10, vIL-10) shares
       several of the cellular cytokine's activities, one or all of which may
       be important in the host-virus relationship. This article reviews recent
       studies on the function of IL-10 and discusses the initial
       characterization of its receptor.
 DE    Animal  Antigen-Presenting Cells/IMMUNOLOGY  Autoimmunity/IMMUNOLOGY
       B-Lymphocytes/CYTOLOGY  Cell Differentiation  Genes, Structural  Genes,
       Structural, Viral  Hematopoiesis  Herpesvirus 4, Human/GROWTH &
       DEVELOPMENT  Human  Immune Tolerance  Inflammation/IMMUNOLOGY
       Interleukin-10/*PHYSIOLOGY  Lymphocyte Transformation  Macrophage
       Activation  Macrophages/IMMUNOLOGY  Receptors, Interleukin/*PHYSIOLOGY
       T-Lymphocytes/IMMUNOLOGY  Th1 Cells/IMMUNOLOGY  Th2 Cells/IMMUNOLOGY
       JOURNAL ARTICLE  REVIEW  REVIEW, ACADEMIC

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

