       Document 0039
 DOCN  M9620039
 TI    Trends in infectious diseases and cancers among persons dying of HIV
       infection in the United States from 1987 to 1992.
 DT    9602
 AU    Selik RM; Chu SY; Ward JW; Centers for Disease Control and Prevention,
       Atlanta, Georgia,; USA.
 SO    Ann Intern Med. 1995 Dec 15;123(12):933-6. Unique Identifier : AIDSLINE
       MED/96072649
 AB    OBJECTIVE: To determine trends in the relative frequency of infectious
       diseases and cancers among U.S. residents dying of human
       immunodeficiency virus (HIV) infection. DATA SOURCE: National
       multiple-cause mortality data for 1987 to 1992 compiled from death
       certificates. SUBJECTS: Deaths reported with HIV infection as the
       underlying cause and with nonunderlying causes that could be secondary
       to HIV infection. DATA ANALYSIS: Trends in the annual percentage of
       deaths associated with each infectious disease or cancer that accounted
       for at least 1.0% of all HIV-related deaths. RESULTS: From 1987 to 1992,
       the percentage of HIV-related deaths associated with the following
       diseases decreased: pneumocystosis, from 32.5% to 13.8%; cryptococcosis,
       from 7.7% to 5.0%; and candidiasis, from 2.3% to 1.7%. The percentage of
       deaths associated with the following diseases increased: nontuberculous
       mycobacteriosis, from 6.7% to 12.2%; cytomegalovirus disease, from 5.2%
       to 9.9%; bacterial septicemia, from 9.0% to 11.5%; non-Hodgkin lymphoma,
       from 3.9% to 5.7%; tuberculosis, from 2.9% to 4.1%; progressive
       multifocal leukoencephalopathy, from 0.8% to 1.9%; bacterial pneumonia,
       from 1.2% to 2.1%; and cryptosporidiosis or isosporiasis, from 0.7% to
       1.2%. The percentages of deaths associated with toxoplasmosis, Kaposi
       sarcoma, and pneumonia caused by unspecified organisms had no
       significant linear trends (ranges from 4.9% to 5.5%, 10.4% to 12.1%, and
       17.6% to 18.6%, respectively). CONCLUSIONS: The percentage of
       HIV-related deaths associated with pneumocystosis has decreased
       dramatically, probably because of chemoprophylaxis and improved
       treatment. Pneumonia caused by unspecified organisms has now become the
       leading secondary cause of death among persons dying of HIV infection.
       Decreases in the percentages of HIV-related deaths associated with
       cryptococcosis and candidiasis may reflect the use of new antifungal
       agents such as fluconazole.
 DE    AIDS-Related Opportunistic Infections/*MORTALITY  Human  HIV
       Infections/COMPLICATIONS/*MORTALITY  Neoplasms/COMPLICATIONS/*MORTALITY
       United States/EPIDEMIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

