       Document 0375
 DOCN  M9620375
 TI    Isolation of a highly cytopathic lentivirus from a nondomestic cat.
 DT    9602
 AU    Barr MC; Zou L; Holzschu DL; Phillips L; Scott FW; Casey JW; Avery RJ;
       Department of Microbiology and Immunology, College of Veterinary;
       Medicine, Cornell University, Ithaca, New York 14853, USA.
 SO    J Virol. 1995 Nov;69(11):7371-4. Unique Identifier : AIDSLINE
       GENBANK/U31349
 AB    A feline immunodeficiency virus-like virus (FIV-Oma) isolated from a
       Pallas' cat (Otocolobus manul) is highly cytopathic in CrFK cells, in
       contrast to the chronic, noncytolytic infection established by an FIV
       isolate from a domestic cat (FIV-Fca). The virions have typical
       lentivirus morphology, density, and magnesium-dependent reverse
       transcriptase activity. The major core protein is antigenically
       cross-reactive with that of FIV-Fca; however, FIV-Oma transcripts do not
       cross-hybridize with FIV-Fca. A conserved region of the FIV-Oma pol gene
       has 76 to 80% nucleic acid identify with the corresponding pol regions
       of other feline lentiviruses and 64 to 69% identity with those of human,
       ovine, and equine lentiviruses.
 DE    Animal  Animals, Wild  Base Sequence  Blotting, Northern
       Carnivora/*VIROLOGY  Case Report  Cats  Cell Line  Comparative Study
       Conserved Sequence  Genes, pol  Horses  Human  Immunodeficiency Virus,
       Feline/*CLASSIFICATION/*ISOLATION & PURIF/  ULTRASTRUCTURE
       Lentivirus/*CLASSIFICATION/GENETICS/ISOLATION & PURIF  Male  Microscopy,
       Electron  Molecular Sequence Data  RNA-Directed DNA Polymerase/ANALYSIS
       RNA, Messenger/ISOLATION & PURIF  RNA, Viral/ISOLATION & PURIF  Sheep
       Support, Non-U.S. Gov't  Virion/ULTRASTRUCTURE  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

