       Document 0628
 DOCN  M9620628
 TI    T-cell mediated immunosuppression and its implications for the
       development of protective immunity.
 DT    9602
 AU    Baker PJ; Hraba T; Division of Microbiology and Infectious Diseases,
       National; Institute of Allergy and Infectious Diseases, National
       Institutes; of Health, Bethesda, Maryland 20892, USA.
 SO    Folia Biol (Praha). 1994;40(6):349-58. Unique Identifier : AIDSLINE
       MED/96037164
 AB    The mechanisms by which regulatory CD4- CD8+ suppressor T cells (Ts) and
       CD4+ CD8- amplifier T cells (Ta) influence the magnitude of the antibody
       response to the capsular polysaccharide antigen of type III
       Streptococcus pneumoniae are reviewed in detail. This represents the
       best-characterized experimental model system available for demonstrating
       how subsets of T cells act in a negative and positive manner to control
       the magnitude of an antibody response. The fact that transferred Ts and
       Ta elicit their effects in athymic immunized mice affirms, that such
       regulatory T cells are antigen-specific and act on immune B cells to
       produce the effects observed. The ability of the lipid A and the inner
       core-region oligosaccharide fractions of bacterial lipopolysaccharide to
       abolish and increase the expression of Ts function, respectively, is
       examined with respect to its immunomodulatory potential and its possible
       role in enhancing the virulence of Gram-negative bacteria.
 DE    Animal  *Antibody Formation  B-Lymphocytes/*IMMUNOLOGY  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/IMMUNOLOGY  Human
       *Immune Tolerance  *Immunity, Cellular  Lymphocyte Transformation  Mice
       Models, Immunological  Polysaccharides, Bacterial/IMMUNOLOGY
       Streptococcus pneumoniae/IMMUNOLOGY  T-Lymphocyte Subsets/*IMMUNOLOGY
       T-Lymphocytes, Suppressor-Effector/IMMUNOLOGY  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

