       Document 0494
 DOCN  M9620494
 TI    Human immunodeficiency virus DNA in urethral secretions in men:
       association with gonococcal urethritis and CD4 cell depletion.
 DT    9602
 AU    Moss GB; Overbaugh J; Welch M; Reilly M; Bwayo J; Plummer FA;
       Ndinya-Achola JO; Malisa MA; Kreiss JK; Department of Medicine,
       University of Washington, Seattle, USA.
 SO    J Infect Dis. 1995 Dec;172(6):1469-74. Unique Identifier : AIDSLINE
       MED/96083489
 AB    To evaluate the prevalence and correlates of human immunodeficiency
       virus (HIV)-infected cells in urethral secretions, samples were
       collected from 106 HIV-seropositive men with and without urethritis. HIV
       DNA was detected by polymerase chain reaction in 27% of 184 urethral
       specimens and was associated with CD4 cell depletion (P for trend, .03)
       and with urethritis (odds ratio [OR], 2.4; 95% confidence interval [CI],
       1.2-4.6) or gonorrhea (OR, 2.9; 95% CI, 1.5-5.8). Two multivariate
       models were constructed that included age, CD4 cell count < 200/mm3, and
       either urethritis or gonococcal infection. Detection of HIV-infected
       cells in urethral secretions was independently associated with < 200 CD4
       cells/mm3 (OR, 2.2; 95% CI, 0.9-5.2; P = .05) and urethritis (OR, 2.7;
       95% CI, 1.3-5.3; P = .003) in the first model and with gonococcal
       infection (OR, 3.2; 95% CI, 1.6-6.4; P < .001) in the second model.
       Successful treatment of gonococcal urethritis was associated with a
       2-fold reduction in urethral HIV DNA (44% vs. 21%; P = .02). Thus,
       treatment of gonococcal urethritis may be an effective strategy for
       reducing HIV transmission.
 DE    Adult  Base Sequence  CD4 Lymphocyte Count  CD4-Positive
       T-Lymphocytes/*PHYSIOLOGY  DNA, Viral/*ANALYSIS  Gonorrhea/*VIROLOGY
       Human  HIV/GENETICS/*ISOLATION & PURIF  Male  Molecular Sequence Data
       Support, U.S. Gov't, P.H.S.  Urethra/*VIROLOGY  Urethritis/*VIROLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

