       Document 0989
 DOCN  M9620989
 TI    Management of persistent B19 parvovirus infection in AIDS.
 DT    9602
 AU    Ramratnam B; Gollerkeri A; Schiffman FJ; Rintels P; Flanigan TP;
       Department of Medicine, Miriam Hospital, Brown University School; of
       Medicine, Providence, Rhode Island, USA.
 SO    Br J Haematol. 1995 Sep;91(1):90-2. Unique Identifier : AIDSLINE
       MED/96070630
 AB    An HIV+ 26-year-old white man with a CD4 count of 0.06 x 10(9)/l was
       found to have red blood cell aplasia secondary to B19 parvovirus
       infection. Regular infusions of intravenous immunoglobulin (IVIG) were
       begun and resulted in marked reticulocytosis and correction of anaemia.
       The patient has been followed for over 4 years and has become anaemic
       and reticulocytopenic whenever IVIG was interrupted. Serial dot blot
       analysis of the patient's sera for B19 parvovirus DNA showed absence of
       DNA immediately following IVIG treatments but reappearance within 3-6
       weeks. Regular IVIG was effective in controlling but not eradicating B19
       parvovirus infection in this HIV+ patient.
 DE    Adult  AIDS-Related Opportunistic Infections/COMPLICATIONS/*THERAPY
       Case Report  Erythema Infectiosum/COMPLICATIONS/*THERAPY  Follow-Up
       Studies  Human  HIV Seropositivity/*COMPLICATIONS  Immunoglobulins,
       Intravenous/*THERAPEUTIC USE  Male  Red-Cell Aplasia,
       Pure/*THERAPY/VIROLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

