       Document 0593
 DOCN  M9620593
 TI    In vitro influence of Mycoplasma penetrans on activation of peripheral T
       lymphocytes from healthy donors or human immunodeficiency virus-infected
       individuals.
 DT    9602
 AU    Sasaki Y; Blanchard A; Watson HL; Garcia S; Dulioust A; Montagnier L;
       Gougeon ML; Departement du SIDA et des Retrovirus, Institut Pasteur,
       Paris,; France.
 SO    Infect Immun. 1995 Nov;63(11):4277-83. Unique Identifier : AIDSLINE
       MED/96029717
 AB    Mycoplasma penetrans is a mycoplasma species newly isolated from the
       urine of human immunodeficiency virus (HIV)-infected individuals and
       presents the only case in which an association has been found between
       antibodies against a mycoplasma and HIV infection. To further explore
       the effects of M. penetrans on the immune system, we studied the
       influence of this mycoplasma on peripheral blood mononuclear cells
       (PBMCs) from healthy donors and HIV-infected individuals. M. penetrans
       induced, in addition to blastogenesis of PBMCs, a significant
       proliferative response associated with the expression of some activation
       markers such as CD69, HLA-DR, and CD25. This M. penetrans-dependent
       lymphocyte activation was observed not only in healthy donors but also
       in HIV-infected persons at different stages of the disease. In addition,
       our study revealed that both CD4+ and CD8+ T lymphocytes were responsive
       to M. penetrans. Interestingly, the mitogenic activity of M. penetrans
       was associated with mycoplasma cells but not with the supernatants of
       mycoplasma culture. The potent stimulating activity of M. penetrans on T
       lymphocytes from HIV-infected individuals is of particular interest in
       view of the supposed contribution of immune activation to HIV
       replication and disease progression.
 DE    Antigens, CD/METABOLISM  Antigens, CD4/METABOLISM  Antigens,
       Differentiation, T-Lymphocyte/METABOLISM  Cell Division  Cells, Cultured
       Human  HIV Infections/*IMMUNOLOGY  *Lymphocyte Transformation
       Mycoplasma penetrans/*IMMUNOLOGY  Receptors, Interleukin-2/METABOLISM
       Support, Non-U.S. Gov't  T-Lymphocytes/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

