       Document 0814
 DOCN  M9610814
 TI    Magnetic resonance spectroscopy in childhood AIDS encephalopathy.
 DT    9601
 AU    Pavlakis SG; Lu D; Frank Y; Bakshi S; Pahwa S; Barnett TA; Porricolo ME;
       Gould RJ; Nozyce ML; Hyman RA; Department of Radiology, North Shore
       University Hospital,; Manhasset, New York, USA.
 SO    Pediatr Neurol. 1995 May;12(4):277-82. Unique Identifier : AIDSLINE
       MED/96044396
 AB    Twenty-five children with acquired immunodeficiency syndrome (AIDS)
       underwent cranial magnetic resonance imaging and proton magnetic
       resonance spectroscopy. Patients were divided into 2 groups based on
       clinical parameters: encephalopathy and nonencephalopathy. N-acetyl
       aspartate/creatine ratios were compared between the 2 groups and to
       control data. Spectra were obtained for 2 volumes of interest: the basal
       ganglia region and the white matter. The mean basal ganglia region ratio
       for the AIDS encephalopathy patients (n = 8) was 1.12 and the ratio for
       the AIDS nonencephalopathy patients (n = 17) was 1.48. The ratio for the
       9 controls was 1.57. The encephalopathy group had a significantly lower
       ratio than both the control (P < .001) and the AIDS nonencephalopathy
       group (P < .002). The mean white matter ratio for the encephalopathy
       group (n = 8) was 1.47 and for the AIDS nonencephalopathy group (n = 13)
       was 1.82 with a control (n = 6) ratio of 1.82. The encephalopathy
       patients had a lower white matter ratio than the nonencephalopathy (P <
       .05) patients but the ratio was not different than controls (P < .11).
       It is concluded that N-acetyl aspartate/creatine ratios are reduced in
       childhood AIDS encephalopathy and proton magnetic resonance spectroscopy
       may be helpful in defining brain human immunodeficiency virus-1
       infection. However, further longitudinal studies are necessary to
       determine the sensitivity and specificity of this technique.
 DE    Adolescence  AIDS Dementia Complex/*DIAGNOSIS  Basal Ganglia/*PATHOLOGY
       Case-Control Studies  Child  Child, Preschool  Human  Infant  Magnetic
       Resonance Imaging  *Nuclear Magnetic Resonance  Protons  Support,
       Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

