       Document 0810
 DOCN  M9610810
 TI    Th1 and Th2 subsets: paradigms lost?
 DT    9601
 AU    Kelso A; Transplantation Biology Unit, Queensland Institute of Medical;
       Research, Brisbane, Australia.
 SO    Immunol Today. 1995 Aug;16(8):374-9. Unique Identifier : AIDSLINE
       MED/96002281
 AB    The T helper 1 (Th1)/Th2 model has provided a valuable framework to
       investigate and explain many immune reactions and now pervades current
       thinking on the regulatory role of T cells. However, individual T cells
       and clones display remarkable diversity in their cytokine profiles,
       collectively forming a continuous spectrum in which Th1 and Th2 cells
       may be only two of the possible extreme phenotypes. For these reasons,
       Anne Kelso argues that cytokine-producing T cells cannot be classified
       into discrete subsets.
 DE    Animal  Clone Cells/METABOLISM/SECRETION
       Cytokines/BIOSYNTHESIS/GENETICS/*SECRETION  Gene Expression Regulation
       Immunization  Immunophenotyping  Mice  Mice, Inbred BALB C  Mice, Inbred
       C57BL  Mice, Inbred DBA  *Models, Immunological  Support, Non-U.S. Gov't
       *T-Lymphocyte Subsets  Th1 Cells/*IMMUNOLOGY/METABOLISM/SECRETION  Th2
       Cells/*IMMUNOLOGY/METABOLISM/SECRETION  JOURNAL ARTICLE  REVIEW  REVIEW,
       TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

