       Document 0809
 DOCN  M9610809
 TI    The role of IL-12 in the induction of organ-specific autoimmune
       diseases.
 DT    9601
 AU    Trembleau S; Germann T; Gately MK; Adorini L; Roche Milano Ricerche,
       Italy.
 SO    Immunol Today. 1995 Aug;16(8):383-6. Unique Identifier : AIDSLINE
       MED/96002283
 AB    The concept that T cells are subdivided into T helper 1 (Th1) and Th2
       subsets was recently extended to suggest that Th1 cells contribute to
       the pathogenesis of several organ-specific autoimmune diseases, whereas
       Th2 cells inhibit disease development. Here, Sylvie Trembleau and
       colleagues examine the role of interleukin 12 (IL-12), a key cytokine
       guiding the development of Th1 cells, in the induction of autoimmune
       diseases, and discuss potential immunointervention strategies based on
       administration of IL-12 antagonists.
 DE    Animal  Antibodies, Monoclonal/IMMUNOLOGY/PHARMACOLOGY/THERAPEUTIC USE
       Arthritis/CHEMICALLY INDUCED/IMMUNOLOGY  Autoimmune Diseases/CHEMICALLY
       INDUCED/DRUG THERAPY/*IMMUNOLOGY  Collagen/TOXICITY  Diabetes Mellitus,
       Insulin-Dependent/CHEMICALLY INDUCED/  IMMUNOLOGY  Drug Design
       Encephalomyelitis, Allergic/IMMUNOLOGY/THERAPY  Female
       Immunosuppressive Agents/PHARMACOLOGY/THERAPEUTIC USE  Immunotherapy,
       Adoptive  Interleukin-12/ANTAGONISTS & INHIB/*PHYSIOLOGY/TOXICITY  Mice
       Mice, Inbred BALB C  Mice, Inbred NOD  Models, Immunological  Organ
       Specificity/*IMMUNOLOGY  Th1 Cells/*IMMUNOLOGY  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

