       Document 0806
 DOCN  M9610806
 TI    Progression of HIV infection is associated with HLA-DQ antigens in
       Caucasians and African Americans.
 DT    9601
 AU    Brackin MN; Lewis RE; Brackin BT; Achord A; Henderson H; Crawford M;
       Cruse JM; Department of Pathology, University of Mississippi Medical;
       Center, Jackson 39216, USA.
 SO    Pathobiology. 1995;63(1):22-41. Unique Identifier : AIDSLINE
       MED/96055646
 AB    In our previous work with human leukocyte antigen (HLA) association in
       human immunodeficiency virus (HIV) infection, African Americans (Afr
       Ams) and Caucasians (Caucs) exhibited HLA markers that were associated
       with protection or disease. The present study was designed to establish
       if HLAs were associated with the severity of HIV infection and
       progression to AIDS in Afr Am and Cauc adults. The frequency of
       serologically determined antigens (Ags) in the regional control
       population was compared to the HIV-infected population and the
       HIV-infected slow progressors were compared to rapid progressors by
       race. chi 2 analysis with Bonferroni adjustment, Kaplan-Meier survival
       analysis, linear logistic regression, Cox model of proportional hazards
       and standardized deltas were applied as applicable. Immune parameters
       were monitored over a mean follow-up period of 23 +/- 2 months for Afr
       Ams (n = 35) and 25 +/- 5 months for Caucs (n = 24). A better prognosis
       in the HIV+Afr Am group was associated with HLA-DQ1 with a risk ratio of
       0.295. In the HIV+Cauc group, a preferable prognosis was associated with
       HLA-DQ3 with a risk ratio of 0.11, and a poor prognosis was associated
       with HLA-DQ2 with a risk ratio of 7. Afr Am haplotypes that appeared to
       have the greatest association with rapid progression of HIV infection
       were A69(28)-B40 and related haplotypes as well as B12-DR14(6). Cauc
       haplotypes with the strongest association with rapid and slow
       progression of HIV infection were A28-B17-DR9 and A30(19)-B67,
       respectively. The DR Ags of at least one haplotype that led to rapid
       progression in both races were associated with DQ9(3). An 'immune
       response' gene (DQ region) may control the progression of HIV infection
       in adults. The rapidly progressive DQ-associated peptide might block the
       progression of HIV if given as a novel vaccine.
 DE    Adolescence  Adult  Alleles  Blotting, Western  Caucasoid Race/*GENETICS
       Disease Progression  Female  HIV
       Infections/*IMMUNOLOGY/MORTALITY/PHYSIOPATHOLOGY  HLA-DQ
       Antigens/GENETICS/*PHYSIOLOGY  Haplotypes  Human  Linear Models
       Longitudinal Studies  Male  Middle Age  Negroid Race/*GENETICS
       Phenotype  Severity of Illness Index  Support, U.S. Gov't, P.H.S.
       Survival Analysis  T-Lymphocytes/IMMUNOLOGY/PATHOLOGY  United
       States/EPIDEMIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

