       Document 0800
 DOCN  M9610800
 TI    Positive selection of T cells.
 DT    9601
 AU    Fowlkes BJ; Schweighoffer E; Laboratory of Cellular and Molecular
       Immunology, National; Institute of Allergy and Infectious Diseases,
       Bethesda, USA.
 SO    Curr Opin Immunol. 1995 Apr;7(2):188-95. Unique Identifier : AIDSLINE
       MED/96053437
 AB    In the past year, significant technical developments have provided the
       opportunity to investigate the more mechanistic features of positive
       selection. Major progress has been made in determining the structure and
       function of the early pre-T cell receptor, in defining cell types that
       mediate positive selection, and in analyzing the contribution of MHC and
       co-receptors to CD4/CD8 lineage commitment. The most revealing studies
       have been those addressing the role of peptides in thymic selection.
 DE    Animal  Cell Differentiation/*GENETICS  CD4-Positive
       T-Lymphocytes/*IMMUNOLOGY  CD8-Positive T-Lymphocytes/*IMMUNOLOGY
       Receptors, Antigen, T-Cell/*GENETICS  JOURNAL ARTICLE  REVIEW  REVIEW,
       TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

