       Document 0798
 DOCN  M9610798
 TI    Activation-induced death of mature T cells in the regulation of immune
       responses.
 DT    9601
 AU    Russell JH; Department of Molecular Biology and Pharmacology,
       Washington; University School of Medicine, St Louis, MO 63110, USA.
 SO    Curr Opin Immunol. 1995 Jun;7(3):382-8. Unique Identifier : AIDSLINE
       MED/96057968
 AB    Deletion of self-reactive clones of immature thymocytes by
       activation-induced death (AID) is thought to be the primary mechanism
       for the establishment of self-tolerance in the T-cell compartment.
       Recent evidence suggests that a genetically distinct but analogous
       process of AID in mature T cells is important in regulating peripheral
       immune responses. AID of peripheral T cells requires the expression of
       functional Fas and Fas ligand by the T-cell population. As qualitatively
       similar signals from the TCR are responsible for both T-cell expansion
       in inflammation and T-cell elimination by AID, regulating the balance
       between these opposing functions plays a crucial role in successful
       responses to pathogens and tumors while minimizing autoimmunity.
 DE    Animal  Antigen Presentation/IMMUNOLOGY/PHYSIOLOGY  Antigens,
       CD28/IMMUNOLOGY/PHYSIOLOGY  Antigens, CD95/IMMUNOLOGY/PHYSIOLOGY
       *Apoptosis  Cytokines/IMMUNOLOGY/PHYSIOLOGY  Cytotoxicity, Immunologic
       Ligands  *Lymphocyte Transformation  Mice  Mice, Inbred Strains  Models,
       Immunological  T-Lymphocytes/*IMMUNOLOGY/PHYSIOLOGY  Th1
       Cells/IMMUNOLOGY/PHYSIOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

