       Document 0789
 DOCN  M9610789
 TI    Relation between stage of disease and neurobehavioral measures in
       children with symptomatic HIV disease.
 DT    9601
 AU    Brouwers P; Tudor-Williams G; DeCarli C; Moss HA; Wolters PL; Civitello
       LA; Pizzo PA; Pediatric Branch, National Cancer Institute, NIH Clinical
       Center,; Bethesda, MD 20892-1928, USA.
 SO    AIDS. 1995 Jul;9(7):713-20. Unique Identifier : AIDSLINE MED/96035234
 AB    OBJECTIVE: To study the relationships between stage of HIV disease,
       reflected by CD4+ lymphocyte percentages and p24 antigen levels, and
       HIV-associated central nervous system (CNS) abnormalities, measured by
       computed tomography (CT) brain-scan ratings and neurobehavioral tests.
       DESIGN: Consecutive case series. SETTING: Government medical research
       center. PATIENTS: Eighty-six previously untreated children with
       symptomatic HIV-1 disease. RESULTS: CD4% measures correlated
       significantly with overall CT brain-scan severity ratings (r = -0.45; P
       < 0.001) as well as with its component parts (cortical atrophy, white
       matter abnormalities, and intracerebral calcifications); they were of
       comparable magnitude for vertically and transfusion-infected children.
       CD4% measures were also associated with the general level of cognitive
       function (r = 0.32; P < 0.005). Furthermore, patients with detectable
       serum p24 antigen levels (n = 39) had CT brain scans that were more
       abnormal than patients with undetectable p24 levels (n = 20; CT
       abnormality ratings of 21.3 versus 35.9; P < 0.02); similar differences
       were found for the cortical atrophy and calcification ratings. p24
       levels also correlated with the overall CT brain-scan severity rating (r
       = 0.34; P < 0.01). CONCLUSIONS: Degree of CT brain-scan abnormality and
       level of cognitive dysfunction were significantly associated with the
       stage of HIV-1 disease, as reflected by either CD4 leukocyte measures or
       elevations of p24 antigen. The relation between the CT brain-scan
       lesions and markers of HIV disease (both CD4 and p24) suggest that these
       CNS abnormalities are most likely associated with HIV-1 infection, and
       further support the hypothesis that the interaction between systemic
       disease progression and CNS manifestations is continuous rather than
       discrete.
 DE    Adolescence  AIDS Dementia
       Complex/*DIAGNOSIS/PHYSIOPATHOLOGY/RADIOGRAPHY  Brain/RADIOGRAPHY  Child
       Child, Preschool  CD4 Lymphocyte Count  Female  Human  HIV Core Protein
       p24/ANALYSIS  HIV-1  Infant  Male  Neuropsychological Tests  Tomography,
       X-Ray Computed  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

