       Document 0763
 DOCN  M9610763
 TI    Listeria monocytogenes: a live vector able to deliver heterologous
       protein within the cytosol and to drive a CD8 dependent T cell response.
 DT    9601
 AU    Goossens PL; Montixi C; Saron MF; Rodriguez M; Zavala F; Milon G; Unite
       d'Immunophysiologie cellulaire, Institut Pasteur, Paris,; France.
 SO    Biologicals. 1995 Jun;23(2):135-43. Unique Identifier : AIDSLINE
       MED/96012508
 AB    After an introduction on the entry and lifestyle of Listeria
       monocytogenes within mammalian eucaryotic cells, this chapter gives a
       brief overview of murine experimental listeriosis. Among the main
       characteristics of this murine model of infectious/pathogenic processes
       initiated by a facultative intracellular bacteria, we point out two main
       recent advances. One relates to Listeria monocytogenes-induced
       production of cytokines as local, and transient signals able to direct
       the immune responses along a type 1 pathway of CD4/CD8 T cell
       differentiation. The other relates (a) to the recognition of L.
       monocytogenes-reactive CD8+ T lymphocytes as effectors able, once
       recruited within infected loci, to critically contribute to the complete
       clearance of the bacteria, and (b) to the recently recognized
       specificity of some of these CD8 lymphocytes in BALB/c mice. In this
       paper, we also briefly review (a) the readout assays presently used to
       monitor the outcome of the infectious/pathogenic processes and the
       related development and expression of immune responses induced by
       intravenous inoculation of wild-type virulent or attenuated L.
       Monocytogenes, (b) why all this information allows us to consider the
       use of L monocytogenes of attenuated virulence as relevant live
       recombinant vectors in order to deliver heterologous proteins to the
       class I processing and presentation pathway, and to induce CD8 T cells
       along the type 1 pathway.
 DE    Animal  Antigens, CD8/IMMUNOLOGY  Bacterial Vaccines/*IMMUNOLOGY
       Cytokines/BIOSYNTHESIS  Cytosol/IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/*IMMUNOLOGY  Human  Immunity, Cellular  Listeria
       monocytogenes/*IMMUNOLOGY/PHYSIOLOGY  Mice  Mice, Inbred BALB C
       Support, Non-U.S. Gov't  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

