       Document 0753
 DOCN  M9610753
 TI    Frequent detection of antibodies against HTLV antigens in patients with
       AIDS-related non-Hodgkin lymphoma.
 DT    9601
 AU    Zehender G; Meroni L; Piconi S; De Maddalena C; Parravicini C; Clerici
       M; Ridolfo AL; Moroni M; Galli M; Clinica delle Malattie Infettive,
       University of Milan, Italy.
 SO    AIDS Res Hum Retroviruses. 1995 Jul;11(7):823-7. Unique Identifier :
       AIDSLINE MED/96053845
 AB    We studied the prevalence of anti-HTLV-I/II antibodies in 22 patients
       with AIDS-related non-Hodgkin lymphoma (NHL), 453 HIV-1-infected
       patients without lymphoma (194 of whom were diagnosed as having AIDS),
       and 6 HIV-1-positive and 75 HIV-1-negative patients with Hodgkin
       lymphoma. The frequency of serological reactivity against HTLV antigens
       was significantly higher in the AIDS patients with lymphoma than in
       those without (8 of 22, 36.4% vs. 20 of 194, 10.3%-p = 0.0027). One of
       the HIV-1-positive and none of the HIV-1-negative patients with Hodgkin
       lymphoma showed anti-HTLV-I/II reactivity. Four of the eight
       seropositive NHL patients showed antibodies directed against HTLV-II
       recombinant antigens when tested for serological discrimination in a
       Western blot assay. A PCR study of PBMCs from the only patient with NHL
       still alive at the time of the study showed HTLV-II-specific sequences
       in the genomic DNA. These data suggest that HTLV-II or a closely
       homologous retrovirus infects a high proportion of patients with
       AIDS-associated NHL.
 DE    Adult  Blotting, Western  DNA, Viral/ANALYSIS  Enzyme-Linked
       Immunosorbent Assay  Female  Human  HTLV-I Antibodies/*BLOOD  HTLV-I
       Antigens/IMMUNOLOGY  HTLV-II/GENETICS/ISOLATION & PURIF  HTLV-II
       Antibodies/*BLOOD  HTLV-II Antigens/IMMUNOLOGY  Lymphoma,
       AIDS-Related/BLOOD/*IMMUNOLOGY/PATHOLOGY/*VIROLOGY  Male  Middle Age
       Polymerase Chain Reaction  Retrospective Studies  Support, Non-U.S.
       Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

