       Document 0729
 DOCN  M9610729
 TI    Stability of Th1 and Th2 populations.
 DT    9601
 AU    Perez VL; Lederer JA; Lichtman AH; Abbas AK; Department of Pathology,
       Brigham & Women's Hospital, Boston, MA; 02115, USA.
 SO    Int Immunol. 1995 May;7(5):869-75. Unique Identifier : AIDSLINE
       MED/96053549
 AB    Using an in vitro model for the development of IFN-gamma-producing (Th1)
       and IL-4-producing (Th2) cells from CD4+ T lymphocytes expressing a
       transgenic TCR, we show that IL-12 and IL-4 are the most potent stimuli
       for the differentiation of naive T cells to effector populations. When
       combinations of cytokines are present during T cell priming, the effect
       of IL-4 is dominant. Furthermore, differentiated Th1 cells can be
       converted into IL-4 producers by exposure to IL-4, but the Th2 phenotype
       is not reversible. The stability of Th2 populations may limit the
       ability to regulate Th2-dominant responses in pathologic situations.
 DE    Animal  Cell Differentiation/DRUG EFFECTS/*IMMUNOLOGY  Cells, Cultured
       CD4-Positive T-Lymphocytes/CYTOLOGY/IMMUNOLOGY
       Interleukin-12/PHARMACOLOGY  Interleukin-4/PHARMACOLOGY  Lymphocyte
       Transformation/DRUG EFFECTS/*PHYSIOLOGY  Mice  Mice, Transgenic
       Receptors, Antigen, T-Cell/IMMUNOLOGY  Support, Non-U.S. Gov't  Support,
       U.S. Gov't, P.H.S.  Th1 Cells/CYTOLOGY/*IMMUNOLOGY  Th2
       Cells/CYTOLOGY/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

