       Document 0716
 DOCN  M9610716
 TI    The activity of candidate virucidal agents, low pH and genital
       secretions against HIV-1 in vitro.
 DT    9601
 AU    O'Connor TJ; Kinchington D; Kangro HO; Jeffries DJ; Department of
       Virology, Medical College, St Bartholomew's; Hospital, London, UK.
 SO    Int J STD AIDS. 1995 Jul-Aug;6(4):267-72. Unique Identifier : AIDSLINE
       MED/96056097
 AB    The effect of low pH, normally present in the female genital tract, on
       HIV viability was examined. HIV is more acid stable than previously
       reported with no substantial reduction in infectivity occurring until pH
       levels are reduced below 4.5. The virucidal activity of 3 topical
       spermicides and chlorhexidine was assessed in vitro using previously
       established and newly modified assay systems. None of the agents tested
       had a selectivity index (SI) greater than 5.2. Semen and cervical
       secretions were assessed for their ability to inhibit HIV-1. While no
       virucidal effect was found in the latter, seminal fluid was found to
       have significant activity against HIV-1 and a SI of approximately 50.
 DE    Administration, Intravaginal  Anti-Infective Agents, Local/*PHARMACOLOGY
       Benzalkonium Compounds/PHARMACOLOGY  Cell Adhesion  Cervix Mucus/DRUG
       EFFECTS/*MICROBIOLOGY  Chlorhexidine/PHARMACOLOGY  Drug Screening
       Female  Human  Hydrogen-Ion Concentration  HIV-1/*DRUG
       EFFECTS/PATHOGENICITY  Male  Nonoxynol/PHARMACOLOGY
       Octoxynol/PHARMACOLOGY  Semen/DRUG EFFECTS/*MICROBIOLOGY  Spermatocidal
       Agents/*PHARMACOLOGY  Support, Non-U.S. Gov't  Time Factors  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

