       Document 0714
 DOCN  M9610714
 TI    Clinical features and serum beta 2-microglobulin levels in HIV-1
       positive and negative Tanzanian patients with tuberculosis.
 DT    9601
 AU    Kennedy N; Whitelaw FM; Gutmann J; Berger L; Uiso L; Ngowi FI; Gillespie
       SH; University Division of Communicable Diseases, Royal Free Hospital;
       School of Medicine, London, UK.
 SO    Int J STD AIDS. 1995 Jul-Aug;6(4):278-83. Unique Identifier : AIDSLINE
       MED/96056099
 AB    Serum beta 2-microglobulin (beta 2M) rises in the later stages of HIV
       disease and has therefore been used to monitor progression to AIDS.
       However, little work has been done on patients co-infected with HIV and
       tuberculosis. We studied clinical features and serum beta 2-M in 35
       Tanzanian patients treated for pulmonary tuberculosis (9 HIV-positive,
       26 HIV-negative). The provisional WHO clinical definition of AIDS for
       use in Africa was fulfilled by 89% of the HIV-positive and 65% of the
       HIV-negative patients. Median serum beta 2-M on admission was slightly
       higher in HIV-positive (3.17 mg/l) than in HIV-negative (2.85 mg/l)
       patients. Serum beta 2-M fell during treatment in 17/24 (71%) of
       HIV-negative and 3/7 (43%) HIV-positive patients followed up for 6
       months. We conclude that serum beta 2-M is frequently raised in active
       tuberculosis, and is therefore an unreliable indicator of the stage of
       HIV disease in co-infected patients. The WHO clinical definition of AIDS
       also proved unreliable in patients with tuberculosis.
 DE    beta 2-Microglobulin/*METABOLISM  Adult  Antitubercular
       Agents/THERAPEUTIC USE  AIDS-Related Opportunistic
       Infections/*BLOOD/DRUG THERAPY  Female  Follow-Up Studies  Human  *HIV
       Seronegativity  *HIV-1  Male  Support, Non-U.S. Gov't  Survival Analysis
       Tanzania  Tuberculosis, Pulmonary/*BLOOD/DRUG THERAPY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

