       Document 0704
 DOCN  M9610704
 TI    Injection drug use and human immunodeficiency virus infection.
 DT    9601
 AU    Alcabes P; Friedland G; Yale University AIDS Program, New Haven,
       Connecticut 06510, USA.
 SO    Clin Infect Dis. 1995 Jun;20(6):1467-79. Unique Identifier : AIDSLINE
       MED/96034936
 AB    In this paper we discuss the epidemiology and natural history of human
       immunodeficiency virus (HIV) infection in users of injection drugs. Use
       of injection drugs plays a central role in the HIV infection/AIDS
       epidemic in the United States, Europe, and many parts of the developing
       world. The significance of this role has been underappreciated until
       quite recently because of a number of factors. One factor has been
       systematic, albeit inadvertent, underreporting of cases of HIV disease
       and AIDS in drug injectors as a consequence of the initially narrow
       surveillance case definition for AIDS. A measure of this phenomenon has
       been the disproportionately larger increment of new cases in this
       population with each successive revision of the Centers for Disease
       Control and Prevention's surveillance case definition for AIDS. Other
       reasons for the underappreciation of the magnitude and consequences of
       HIV infection and AIDS in injection drug users include the lack of
       necessary diagnostic facilities in the institutions where drug users are
       often treated, high mortality rates among HIV-infected drug users for
       whom a diagnosis of AIDS has not yet been made, the severe
       marginalization of this population and its lack of advocates, and the
       localization of the initial epidemic in this population to certain
       geographic areas.
 DE    Human  HIV Infections/COMPLICATIONS/EPIDEMIOLOGY/PHYSIOPATHOLOGY/
       *TRANSMISSION  Risk Factors  Substance Abuse, Intravenous/*COMPLICATIONS
       JOURNAL ARTICLE  REVIEW  REVIEW, ACADEMIC

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

