       Document 0696
 DOCN  M9610696
 TI    [Alpha tumor necrosis factor in central nervous system disease
       associated with HIV infection]
 DT    9601
 AU    Calvo Manuel E; Arranz Garcia F; Sanchez-Portocarrero J; Roca Arbones V;
       Puente M; Elias Arcalis A; Perez-Cecilia E; Nieto Sanchez A; Espinos
       Perez D; Servicio de Medicina Interna I, Hospital Universitario San;
       Carlos, Facultad de Medicina, Universidad Complutense, Madrid.
 SO    An Med Interna. 1995 Jun;12(6):263-6. Unique Identifier : AIDSLINE
       MED/96005176
 AB    The aim of the present study is to evaluate the relationship between the
       alpha tumor necrosis factor (TNF-alpha), interleukin 1 beta (IL-1 beta)
       and the neurological disease associated to the HIV-1 infection and
       different neurological manifestations (15 infections of the CNS and 11
       AIDS-dementia complexes) and 14 from a control group. The mean value of
       TNF-alpha in CSF of patients with HIV-1 infection and AIDS-dementia
       complex was 19.8 +/- 30.6 pg/ml, superior to that of the control group
       (p < 0.05). The group of patients with HIV-1 and opportunistic CNS
       infection has a TNF-alpha value of 28.5 +/- 37.8 pg/ml, that is superior
       to that of the patients with the AIDS-dementia complex (TNF-alpha = 7.9
       +/- 9.4 pg ml; p < 0.05). Within the group of patients with a CNS
       infection, the value of TNF-alpha was greater in those in the acute
       phase (44.2 +/- 42.4 pg/ml) than in those in the chronic phase (6.8 +/-
       7.6 pg/ml; p < 0.05). The TNF-alpha in the CSF is a good marker of
       infection of the CNS in the HIV-1 infection.
 DE    Acquired Immunodeficiency Syndrome/CEREBROSPINAL FLUID/
       COMPLICATIONS/*DIAGNOSIS  AIDS Dementia Complex/*CEREBROSPINAL
       FLUID/DIAGNOSIS  Biological Markers  Central Nervous System
       Diseases/CEREBROSPINAL FLUID/*DIAGNOSIS/  ETIOLOGY  Comparative Study
       Data Interpretation, Statistical  English Abstract  Enzyme-Linked
       Immunosorbent Assay  Human  HIV-1  Interleukin-1/BLOOD  Tumor Necrosis
       Factor/*CEREBROSPINAL FLUID  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

