       Document 0686
 DOCN  M9610686
 TI    Mycobacteria in HIV-infected patients in Buenos Aires.
 DT    9601
 AU    Di Lonardo M; Isola NC; Ambroggi M; Rybko A; Poggi S; Dr A. Cetrangolo
       Bacteriology Laboratory, F. J. Muniz Hospital,; Buenos Aires, Argentina.
 SO    Tuber Lung Dis. 1995 Jun;76(3):185-9. Unique Identifier : AIDSLINE
       MED/96014883
 AB    SETTING: F. J. Muniz Hospital and Department of Phthisiopneumonology, in
       Buenos Aires. OBJECTIVE: To analyze bacteriological findings concerning
       tuberculosis and other mycobacteriosis, in association with HIV
       infection and AIDS. DESIGN: From June 1985 to December 1991, 2521
       samples from 1259 HIV-seropositive and AIDS patients were analyzed: 1133
       samples were of bronchopulmonary origin and the remaining 1388 of
       extrapulmonary origin. Drug susceptibility tests were performed using
       the proportions method. RESULTS: Mycobacterial disease was confirmed by
       culture in 240 of the 1259 HIV/AIDS patients (19%). Mycobacterium
       tuberculosis was isolated in 223 of these cases (92.9%) and M. bovis in
       two, while M. avium-complex (MAC) strains were identified as the cause
       of disease in 14 patients (5.8%). In only one case was disease due to M.
       kansasii. Blood cultures were positive in 21.2% of these 240 cases.
       Resistance of M. tuberculosis to antituberculosis drugs was found in
       9.4% of the 223 isolates. In only one case was multidrug resistance
       detected, in a patient who had received previous treatment. CONCLUSION:
       Smear examination, although less sensitive than in HIV-negative
       patients, was still a simple and reliable tool for the rapid diagnosis
       of mycobacterial disease. Blood culture aided in the successful
       diagnosis of about half of the cases of disseminated tuberculosis and of
       all cases of MAC disease. An alarming spread of tuberculosis was
       detected among a group of HIV-positive prisoners, and the possible
       emergence of multidrug resistance should be anticipated.
 DE    Antitubercular Agents/PHARMACOLOGY  Argentina/EPIDEMIOLOGY  AIDS-Related
       Opportunistic Infections/*COMPLICATIONS/EPIDEMIOLOGY  Bacteriological
       Techniques  Drug Resistance, Microbial  Female  Human  HIV
       Seropositivity/*COMPLICATIONS  Male  Mycobacterium/*ISOLATION & PURIF
       Mycobacterium Infections/*COMPLICATIONS/EPIDEMIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

