       Document 0657
 DOCN  M9610657
 TI    Survival trends in adolescents with human immunodeficiency virus
       infection.
 DT    9601
 AU    Remafedi G; Lauer T; Department of Pediatrics, University of Minnesota
       Hospital and; Clinics, Minneapolis, USA.
 SO    Arch Pediatr Adolesc Med. 1995 Oct;149(10):1093-6. Unique Identifier :
       AIDSLINE MED/96003536
 AB    OBJECTIVE: To examine trends in survival and death in nonhemophiliac
       adolescents with human immunodeficiency virus (HIV) infection. DESIGN:
       Case series. SUBJECTS: All 117 HIV-seropositive adolescents (age range,
       13 to 21 years) without hemophilia whose cases were reported through
       December 1992. SETTING: A state with mandatory, name-linked reporting of
       cases of HIV. METHODS: Review of death certificates and public records,
       and interviews with subjects and key informants. ANALYSES: Kaplan-Meier
       and Cox proportional hazards regression analyses of time from the
       diagnosis of HIV infection to death. RESULTS: Documentation of death or
       survival was available for 92% (108/117) of the sample. Fourteen percent
       (15/108) of the subjects were known to have died, mainly of
       well-recognized complications of acquired immunodeficiency syndrome.
       Among deceased subjects, the median duration of survival after the
       diagnosis of HIV was 3 years. Cumulative survival at 8 years after the
       diagnosis was 52%, with 4 years being the median period of observation
       (range, < 1 year to 8 years). Stratification of survival functions by
       gender, race, and mode of transmission revealed no significant (P < .05)
       differences between groups. However, advancing age at the time of the
       diagnosis was inversely associated with survival. CONCLUSIONS: Despite
       an apparent advantage to young age, overall survival in this adolescent
       cohort was shorter than expected. Rather than an inherently rapid
       progression of disease during adolescence, delays in diagnosis and
       treatment might better explain the results.
 DE    Adolescence  Adult  Age Factors  Cause of Death  Disease Notification
       Female  Human  HIV Seropositivity/*MORTALITY  Male  Medical Record
       Linkage  Minnesota/EPIDEMIOLOGY  Population Surveillance  Proportional
       Hazards Models  Support, U.S. Gov't, P.H.S.  Survival Analysis  Survival
       Rate/TRENDS  Time Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

