       Document 0649
 DOCN  M9610649
 TI    Human T lymphotropic virus, type-I myelopathy: an immunopathologically
       mediated chronic progressive disease of the central nervous system.
 DT    9601
 AU    Jacobson S; Viral Immunology Section, National Institute of
       Neurological; Disorders and Stroke, National Institutes of Health,
       Bethesda,; Maryland, USA.
 SO    Curr Opin Neurol. 1995 Jun;8(3):179-83. Unique Identifier : AIDSLINE
       MED/96023834
 AB    The human T lymphotropic virus, type-I is associated with a slowly
       progressive neurologic disorder termed human T lymphotropic virus,
       type-I associated myelopathy/tropical spastic paraparesis. Considerable
       information on the pathology, epidemiology, virology, and immunology is
       known about this disorder and will serve as a framework to define the
       role that a human retrovirus can play in human disease. In particular,
       this review will discuss the role of cellular immune responses to the
       virus in patients with human T lymphotropic virus, type-I associated
       myelopathy/tropical spastic paraparesis and how these responses may be
       associated with the pathogenesis of this disorder. By defining
       virus-specific functional cellular host responses we hope to improve our
       understanding of the underlying mechanisms that may be involved in the
       neuropathology of human T lymphotropic virus, type-I associated
       neurologic disease.
 DE    Adult  Brain/IMMUNOLOGY/PATHOLOGY  Chronic Disease  CD8-Positive
       T-Lymphocytes/IMMUNOLOGY  Histocompatibility Antigens Class I/METABOLISM
       Human  HTLV-I/*IMMUNOLOGY  HTLV-I Antigens/IMMUNOLOGY  Immunity,
       Cellular/*IMMUNOLOGY  Lymphocyte Transformation/IMMUNOLOGY  Neurologic
       Examination  Paraparesis, Tropical
       Spastic/DIAGNOSIS/*IMMUNOLOGY/PATHOLOGY  Spinal
       Cord/IMMUNOLOGY/PATHOLOGY  T-Lymphocytes, Cytotoxic/IMMUNOLOGY  JOURNAL
       ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

