       Document 0648
 DOCN  M9610648
 TI    Progressive multifocal leukoencephalopathy: clinical and laboratory
       observations on a viral induced demyelinating disease in the
       immunodeficient patient.
 DT    9601
 AU    Major EO; Ault GS; Laboratory of Molecular Medicine and Neuroscience,
       National; Institute of Neurological Disorders and Stroke, Bethesda,;
       Maryland, USA.
 SO    Curr Opin Neurol. 1995 Jun;8(3):184-90. Unique Identifier : AIDSLINE
       MED/96023835
 AB    Progressive multifocal leukoencephalopathy is a viral-induced
       demyelinating disease of the central nervous system usually occurring in
       the immunocompromised individual. The incidence of progressive
       multifocal leukoencephalopathy has risen sharply over the past decade
       because of widespread human immunodeficiency virus infection leading to
       immunodeficiency. This increased incidence of progressive multifocal
       leukoencephalopathy may also be due to better recognition of its
       clinical signs, and more rapid and reliable laboratory diagnosis of JC
       virus, the etiologic agent. There have also been advances in the
       molecular detection of the JC virus and the identification of variations
       in the viral genome sequence that may affect its multiplication cycle in
       different tissues. Clinical and basic research have resulted in a better
       understanding of the pathogenesis of progressive multifocal
       leukoencephalopathy and have provided sufficient information to plan new
       approaches for treatment.
 DE    Antiviral Agents/THERAPEUTIC USE  AIDS-Related Opportunistic
       Infections/*DIAGNOSIS/DRUG THERAPY/  VIROLOGY  Cytarabine/THERAPEUTIC
       USE  Human  Leukoencephalopathy, Progressive Multifocal/*DIAGNOSIS/DRUG
       THERAPY/VIROLOGY  Polymerase Chain Reaction  Polyomavirus hominis 2/DRUG
       EFFECTS/GENETICS/ISOLATION & PURIF  Virus Replication/DRUG
       EFFECTS/GENETICS  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

