       Document 0646
 DOCN  M9610646
 TI    IgE antibodies against snake venoms.
 DT    9601
 AU    Alonso A; Scavini LM; Marino GA; Rodriguez SM; Department of Allergy and
       Immunology, Clinical Hospital, Buenos; Aires, Argentina.
 SO    J Investig Allergol Clin Immunol. 1995 Jan-Feb;5(1):31-4. Unique
       Identifier : AIDSLINE MED/96053417
 AB    A similar event was detected in the clinical records of a small group of
       atopic patients living in the northern provinces of Argentina, i.e.,
       they were bitten by a snake of the Bothrops species (or yarara) during
       their rural activities (woodcutters, cattle-drivers and farmers). Those
       who were bitten twice suffered an acute episode of hives and angioedema
       within 15 minutes after the snake bite. The presence of specific
       antibodies against Bothrops alternata (Ba) extract was detected by means
       of RAST for IgE and Ouchterlony and Boyden for IgG. The Ouchterlony also
       demonstrated crossreactivity among the venoms of the Bothrops species
       and the positivity of the six fractions obtained by DEAE-cellulose
       column fractionation against the horse anti-Ba serum. The Ba antigen
       induced a definite inhibition of the RAST. We presume that hives and
       angioedema in atopic patients immediately after a second snake bite
       could be attributed to the presence of a specific IgE antibody against
       the venom, and must not be misinterpreted with the toxic effects that
       appear later.
 DE    Adult  Animal  Asthma/IMMUNOLOGY  Bothrops/*IMMUNOLOGY  Crotalid
       Venoms/*IMMUNOLOGY  Hay Fever/IMMUNOLOGY  Human  Hypersensitivity,
       Immediate/*IMMUNOLOGY  IgE/*BLOOD  Male  Precipitin Tests
       Radioallergosorbent Test  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

