       Document 0640
 DOCN  M9610640
 TI    Monocyte responsiveness and a T-cell subtype predict the effects induced
       by cotton dust exposure.
 DT    9601
 AU    Beijer L; Jacobs RR; Boehlecke B; Andersson B; Rylander R; Department of
       Environmental Medicine, Goteborg University,; Sweden.
 SO    Am J Respir Crit Care Med. 1995 Oct;152(4 Pt 1):1215-20. Unique
       Identifier : AIDSLINE MED/96023195
 AB    The aim of the study was to evaluate whether peripheral cellular
       parameters could predict susceptibility to decreased lung function and
       associated symptoms, in response to a single exposure to cotton dust.
       Previously nonexposed subjects (n = 42) inhaled an aerosol of cotton
       dust in a model cardroom during a period of 5 h. The subjects were
       examined before the exposure for FEV1, procoagulant activity (PCA) in
       blood mononuclear cells (BMNC), and serum IgE antibodies against a pool
       of inhalant antigens. Blood lymphocytes were typed into the
       helper/inducer (CD4+) and cytotoxic/suppressor (CD8+) T cells in
       combination with surface markers subdividing these populations. A
       questionnaire was used to identify atopic and nonatopic subjects.
       Immediately after exposure, the subjects were tested for FEV1 and PCA,
       and symptoms were recorded with a questionnaire. The dust exposure
       induced a decrease in FEV1 that was larger for the atopic group, but did
       not change the PCA in BMNC. The decrease in FEV1 was positively related
       to the preexposure PCA in both atopics and nonatopics. Symptoms from the
       airways after the exposure were reported to the same extent in the
       atopic and nonatopic group, and the subject group reporting chest
       tightness had a larger preexposure PCA. The atopic group had a larger
       proportion of blood CD8+ T lymphocytes negative for the monoclonal
       antibody anti-S6F1 (CD8+S6F1-), and in this group the decrease in FEV1
       was significantly related to the proportion of this cell type. Also, in
       the atopic group, the proportion of CD8+S6F1- cells correlated
       positively with the preexposure PCA, and a negative correlation was
       found for this cell and serum levels of IgE.(ABSTRACT TRUNCATED AT 250
       WORDS)
 DE    Adult  Blood Coagulation Factors/*METABOLISM  Case-Control Studies
       Comparative Study  Cotton/*ADVERSE EFFECTS  CD4-Positive
       T-Lymphocytes/*PHYSIOLOGY  CD8-Positive T-Lymphocytes/*PHYSIOLOGY
       Dust/*ADVERSE EFFECTS  Female  Forced Expiratory Volume/PHYSIOLOGY
       Human  Hypersensitivity, Immediate/BLOOD/*PHYSIOPATHOLOGY  IgE/BLOOD
       Leukocytes, Mononuclear/*PHYSIOLOGY  Lung/*PHYSIOPATHOLOGY  Male
       Spirometry  Support, Non-U.S. Gov't  Support, U.S. Gov't, Non-P.H.S.
       T-Lymphocyte Subsets/*PHYSIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

