       Document 0630
 DOCN  M9610630
 TI    Increase in percentage of CD45RO+/CD8+ cells is associated with previous
       severe primary HIV infection.
 DT    9601
 AU    Bruunsgaard H; Pedersen C; Scheibel E; Pedersen BK; Department of
       Infectious Diseases, Rigshospitalet, Copenhagen,; Denmark.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Oct 1;10(2):107-14.
       Unique Identifier : AIDSLINE MED/96007271
 AB    The purpose of the study was to examine how memory (CD45RO) and naive
       (CD45RA) phenotypes of CD4+ and CD8+ T-cell subpopulations changed with
       respect to progression and duration of human immunodeficiency virus
       (HIV) infection. Forty-three HIV-seropositive (HIV+) subjects with known
       time for seroconversion were included in this cross-sectional study.
       They were divided into the following groups for comparison: persons with
       and without AIDS, persons who had seroconverted > 72 and < 72 months
       before entering the study, persons with or without previous severe
       primary infection, persons who had developed AIDS > 72 and <72 months
       before entering the study. Furthermore, the HIV+ group was compared with
       an HIV-seronegative (HIV-) age- and sex-matched group. There was no
       difference in the proportion of total naive relative to total memory
       cells between HIV+ and HIV- subjects, showing an equal loss of naive and
       memory CD4+ cells in this study. Moreover, there was no difference in
       the proportion of total naive relative to memory CD8+ cells, showing an
       equal increase in both subgroups of CD8+ cells in HIV+ subjects.
       However, HIV+ subjects who had experienced severe primary symptoms
       resembled the AIDS group regarding shift in the CD8 phenotype from naive
       to memory and by down-regulation of amounts of CD45RA protein.
       Furthermore, the results showed that during infection with HIV the
       amounts of both CD45RA and CD45RO markers on CD4+ cells and CD45RA on
       CD8+ cells were down-regulated, although with different
       kinetics.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/PHYSIOPATHOLOGY
       Adolescence  Adult  Aged  Antigens, CD45/*IMMUNOLOGY  Comparative Study
       Cross-Sectional Studies  CD4-Positive T-Lymphocytes/IMMUNOLOGY
       CD8-Positive T-Lymphocytes/CYTOLOGY/*IMMUNOLOGY  Female  Flow Cytometry
       Human  HIV Infections/*IMMUNOLOGY/PHYSIOPATHOLOGY  HIV
       Seropositivity/*IMMUNOLOGY/PHYSIOPATHOLOGY  *HIV-1  Immunophenotyping
       Lymphocyte Count  Male  Middle Age  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

