       Document 0628
 DOCN  M9610628
 TI    Effect of a retroviral immunodeficiency syndrome on resistance to MCMV:
       a role for natural killer cells.
 DT    9601
 AU    Peacock CD; Price P; Department of Microbiology, University of Western
       Australia,; Nedlands.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Oct 1;10(2):120-8.
       Unique Identifier : AIDSLINE MED/96007273
 AB    Mice exhibiting T cell immunodeficiency and lymphadenopathy induced by
       LP-BM5 MuLV (MAIDS) were assessed for their ability to control murine
       cytomegalovirus (MCMV) infection. Elevated replication of MCMV was
       observed in spleens 4-6 days after MCMV infection. Production of
       interferon alpha/beta in response to MCMV was abrogated by MAIDS and
       natural killer (NK) cell activity, assessed by lysis of YAC-1 target
       cells, was correspondingly depressed on Day 1. However, this was
       elevated at later times. As previous studies attribute early control of
       MCMV in C57BL mice with splenic NK1.1 cells, we confirmed that YAC-1
       lysis declines and MCMV titres are elevated in M- mice given antibodies
       to NK1.1 or asialo GM1. However, M+ mice were less severely affected by
       these regimes. Hence M+ mice may acquire cells that do not express NK1.1
       or asialo GM1, but are able to lyse YAC-1 target cells and partially
       control MCMV replication. MCMV was essentially cleared from the spleens
       and livers of M+ and M- mice by Day 11, but in the salivary gland MCMV
       replication was enhanced by MAIDS 11-30 days postinfection. The role of
       CD4 T cells in this phenomenon is being investigated. Since patients
       with acquired immunodeficiency syndrome exhibit suppressed T and NK cell
       activity and experience severe cytomegalovirus disease, the model
       warrants further study.
 DE    Animal  Antibodies/ADMINISTRATION & DOSAGE  Cytomegalovirus
       Infections/*IMMUNOLOGY  Cytotoxicity, Immunologic  Female  Immunity
       Interferon-alpha/BIOSYNTHESIS  Interferon-beta/BIOSYNTHESIS  Killer
       Cells, Natural/*PHYSIOLOGY  Liver/VIROLOGY  Mice  Mice, Inbred C57BL
       Murine Acquired Immunodeficiency Syndrome/*IMMUNOLOGY
       Muromegalovirus/PHYSIOLOGY  Salivary Glands/VIROLOGY
       Spleen/CYTOLOGY/VIROLOGY  Support, Non-U.S. Gov't  Virus Replication
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

