       Document 0608
 DOCN  M9610608
 TI    Natural killer cell immunodeficiency in HIV disease is manifest by
       profoundly decreased numbers of CD16+CD56+ cells and expansion of a
       population of CD16dimCD56- cells with low lytic activity.
 DT    9601
 AU    Hu PF; Hultin LE; Hultin P; Hausner MA; Hirji K; Jewett A; Bonavida B;
       Detels R; Giorgi JV; Department of Medicine, UCLA School of Medicine
       90095-1745, USA.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Nov 1;10(3):331-40.
       Unique Identifier : AIDSLINE MED/96027801
 AB    Natural killer (NK) cells were enumerated by three-color
       immunofluorescence in 255 uninfected and 399 human immunodeficiency
       virus-infected adults. Several dramatic alterations were observed.
       First, the median number and percentage of CD16+CD56+ NK cells, the
       subset that comprises > 90% of the NK cells in healthy adults, were
       severely decreased (median, 175/mm3 in uninfected controls; 63/mm3 in
       HIV-infected non-AIDS subjects). Even subjects with > 800 CD4+ cells/mm3
       had decreased CD16+CD56+ NK cell levels (97/mm3). Second, the number of
       CD16+CD56- cells, an NK population that is rare in healthy adults, was
       elevated (median, 20/mm3 in uninfected controls; 64/mm3 in
       HIV-seropositive non-AIDS subjects). Third, the expression of CD16 on
       the NK cells was markedly reduced; some CD56+ cells and virtually all
       CD56- cells were CD16dim. Fourth, fluorescence-activated cell-sorting
       studies revealed little NK- or antibody-dependent cellular cytotoxic
       activity in the CD16dimCD56- cell population. These results indicate
       that the pathogenesis of HIV disease includes numerical alterations in
       subpopulations of NK cells. A better understanding of how HIV infection
       causes this aspect of pathogenesis is needed.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY  Adult  Antibody-Dependent
       Cell Cytotoxicity/IMMUNOLOGY  Antigens, CD56/*IMMUNOLOGY  Antiviral
       Agents/THERAPEUTIC USE  Cell Separation  Cohort Studies  Cytotoxicity,
       Immunologic  Female  Flow Cytometry  Human  HIV Infections/DRUG
       THERAPY/ETIOLOGY/*IMMUNOLOGY  HIV Seropositivity/IMMUNOLOGY
       Immunophenotyping  Killer Cells, Natural/*IMMUNOLOGY  Lymphocyte Count
       Lymphocyte Subsets/*IMMUNOLOGY  Male  Receptors, IgG/*IMMUNOLOGY
       Regression Analysis  Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE
       MULTICENTER STUDY

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

