       Document 0606
 DOCN  M9610606
 TI    Validity of the Karnofsky Performance Status in an HIV-infected sample.
 DT    9601
 AU    O'Dell MW; Lubeck DP; O'Driscoll P; Matsuno S; Department of Physical
       Medicine and Rehabilitation, University of; Cincinnati, College of
       Medicine, OH 45267-0530, USA.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Nov 1;10(3):350-7.
       Unique Identifier : AIDSLINE MED/96027803
 AB    The Karnofsky Performance Status (KPS) is the most widely used health
       status measure in human immunodeficiency virus (HIV) medicine and
       research. Because there are limited data on KPS metric properties in
       this setting, we present evidence of the construct validity of the KPS
       in a sample of HIV-infected persons using data from the AIDS
       Time-Oriented Health Outcome Study (ATHOS). The sample consisted of 160
       primarily white, homosexual/bisexual men with a mean age of 45 years and
       a mean KPS score of 82 (range, 40-100). Ninety percent were classified
       in Centers for Disease Control (CDC) clinical category B or C. Pearson's
       product-moment correlations were strong between the KPS and measures of
       global health status, physical disability, numbers of symptoms, CDC
       clinical category, social function, days off work, and energy/fatigue (r
       = 0.39-0.52, p < 0.0001). Correlations with measures of mental health
       and cognition were less impressive but statistically significant.
       Analysis of variance followed by Student Newman-Keuls test showed
       significant differences among three KPS groupings for global health
       status but not for physical disability. Regression analysis indicated
       three significant variables accounting for KPS variance: visual analogue
       global health status (27%), days off work (10%), and energy/fatigue
       (1.7%). We conclude that the upper range of the KPS reflects global
       health status better than physical performance and much better than
       psychosocial constructs, in persons with HIV infection. Further research
       examining the ability of the KPS to detect clinically significant change
       over time is needed.
 DE    Adult  Aged  Analysis of Variance  Disabled  Health Status  Health
       Status Indicators  Human  HIV
       Infections/CLASSIFICATION/*PHYSIOPATHOLOGY/PSYCHOLOGY  *Karnofsky
       Performance Status  Male  Middle Age  Quality of Life  Regression
       Analysis  Reproducibility of Results  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

