       Document 0604
 DOCN  M9610604
 TI    Weight loss prior to clinical AIDS as a predictor of survival.
       Multicenter AIDS Cohort Study Investigators.
 DT    9601
 AU    Palenicek JP; Graham NM; He YD; Hoover DA; Oishi JS; Kingsley L; Saah
       AJ; Department of Epidemiology, School of Hygiene and Public Health,;
       Johns Hopkins University, Baltimore, MD, USA.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Nov 1;10(3):366-73.
       Unique Identifier : AIDSLINE MED/96027805
 AB    In this analysis the aim was to determine the independent effect of
       moderate to severe weight loss prior to an AIDS diagnosis on survival
       after AIDS. The study was conducted as part of the Multicenter AIDS
       Cohort Study (MACS), a longitudinal study of HIV-1-seropositive gay or
       bisexual men. Measured weight and self-reported weight loss data were
       collected semiannually from 1984 through 1993. The study population
       included 962 HIV-1-seropositive men who developed clinical AIDS during
       the follow-up period. Median survival after AIDS was significantly lower
       for men with measured weight loss of > or = 4.5 kg 3-9 months and 3-15
       months prior to AIDS, or who had lost > 10% of their baseline body
       weight compared with men with less weight loss or weight gain. Men with
       self-reported unintentional weight loss of > or = 4.5 kg 3-9 months
       prior to AIDS had significantly poorer survival (median = 1.05 years vs.
       1.48 years; p = 0.0001) compared with men not reporting weight loss.
       After adjusting for potential confounding factors, men in the high
       measured weight loss group 3-9 months prior to AIDS still had
       significantly poorer survival [relative hazard (RH) = 1.36; p = 0.02].
       Similar trends were seen for the two longer intervals prior to AIDS (RH
       = 1.38, p = 0.01; and RH = 1.50, p = 0.02, respectively). Men who
       self-reported weight loss > or = 4.5 kg 3-9 months prior to AIDS also
       had significantly poorer survival after AIDS (RH = 1.43; p = 0.002) in
       multivariate analysis.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Acquired Immunodeficiency Syndrome/*MORTALITY/PHYSIOPATHOLOGY  Adult
       Body Weight  Cohort Studies  Comparative Study  Human  HIV
       Seropositivity/*COMPLICATIONS/PHYSIOPATHOLOGY  *HIV-1  Longitudinal
       Studies  Male  Multivariate Analysis  Nutrition  Prospective Studies
       Self Disclosure  Support, U.S. Gov't, P.H.S.  Survival Rate  United
       States/EPIDEMIOLOGY  *Weight Loss  JOURNAL ARTICLE  MULTICENTER STUDY

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

