       Document 0578
 DOCN  M9610578
 TI    Intraoral squamous cell carcinoma in human immunodeficiency virus
       infection. A clinicopathologic study.
 DT    9601
 AU    Flaitz CM; Nichols CM; Adler-Storthz K; Hicks MJ; Department of
       Stomatology, University of Texas Health Science; Center-Houston, USA.
 SO    Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Jul;80(1):55-62.
       Unique Identifier : AIDSLINE MED/96012669
 AB    The purpose of this study was to characterize the clinical and
       histological features of intraoral squamous cell carcinoma in men who
       were seropositive for the human immunodeficiency virus and to evaluate
       viral cofactors (human papillomavirus, herpes simplex virus,
       Epstein-Barr virus), proliferative index (proliferating cell nuclear
       antigen), a factor associated with invasion (cathepsin D), and mutated
       tumor suppressor gene and proto-oncogene products (mutated p53,
       c-erbB-2). Four men who were seropositive for the human immunodeficiency
       virus and had acquired immunodeficiency syndrome presented with painful
       oral lesions of variable duration. Oral cancer risk factors included
       heavy tobacco use (four of four), heavy alcohol use (three of four), and
       previous radiotherapy (one of four). The lesions consisted of ulcers
       (two of four), a fungating mass (one of four), and papillary
       erythroplakia (one of four). Incisional biopsy specimens were obtained.
       High-stringency in situ hybridization was performed with DNA probes to
       the human papillomavirus (types 6/11; 16/18; 31/33/35) and Epstein-Barr
       virus: Immunocytochemical studies for the herpes simplex virus,
       proliferating cell nuclear antigen, cathepsin D, mutated p53, and
       c-erbB-2 were performed. Two lesions were moderately differentiated
       squamous cell carcinoma, one lesion was a basaloid squamous cell
       carcinoma, and one was carcinoma in situ. Stage of disease at diagnosis
       was II (one of four), III (two of four), and IV (one of four). Three
       cases were positive for the human papillomavirus, one case was positive
       for Epstein-Barr virus, and three cases were positive for the herpes
       simplex virus. C-erbB-2 was focally positive in one case, and mutated
       p53 was positive in a separate case.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Adult  Alcohol Drinking/ADVERSE EFFECTS  Carcinoma in
       Situ/ETIOLOGY/PATHOLOGY/VIROLOGY  Carcinoma,
       Basosquamous/ETIOLOGY/PATHOLOGY/VIROLOGY  Carcinoma, Squamous
       Cell/*ETIOLOGY/PATHOLOGY/VIROLOGY  Herpesvirus 4, Human/ISOLATION &
       PURIF  Human  HIV Infections/*COMPLICATIONS  Male  Middle Age  Mouth
       Neoplasms/*ETIOLOGY/PATHOLOGY/VIROLOGY  Papillomavirus, Human/ISOLATION
       & PURIF  Proliferating Cell Nuclear Antigen/ANALYSIS  Protein
       p53/ANALYSIS  Proto-Oncogene Proteins c-erbB-2/ANALYSIS  Risk Factors
       Simplexvirus/ISOLATION & PURIF  Smoking/ADVERSE EFFECTS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

