       Document 0574
 DOCN  M9610574
 TI    AIDS: clinical and scientific issues past, present and future.
 DT    9601
 AU    Dalgleish AG; Moyle GJ; Easterbrook P; Gazzard BG; Division of Oncology,
       St. George's Hospital Medical School,; London, U.K.
 SO    Q J Nucl Med. 1995 Sep;39(3):156-62. Unique Identifier : AIDSLINE
       MED/96033585
 AB    The time from the recognition that AIDS was an infectious disease, to
       the discovery of HIV as the causative agent and the identification of
       the first specific antiviral agent that showed some clinical benefit,
       was impressively short. Over the last few years it would appear that
       progress against AIDS has slowed down considerably. Neither new
       treatments nor vaccines have given much grounds for optimism and back to
       basics has been the main battle cry. However it is easy to overlook the
       tremendous improvements that have taken place in the management of HIV
       disease in the absence of a curative treatment. Many of the
       opportunistic infections that used to kill patients are not only
       treatable but are able to be treated prophylactically. This has altered
       the clinical spectrum of disease with many patients surviving several
       years with virtually no CD4 lymphocytes only to succumb to other HIV
       related disease such as non Hodgkins lymphoma. This review identifies
       the major advances that have occurred in our understanding of AIDS and
       identifies the major problems to be overcome in the next few years at
       both the clinical and basic levels.
 DE    *Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY/PREVENTION &
       CONTROL/THERAPY  Human  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

