       Document 0567
 DOCN  M9610567
 TI    99mTc DTPA transfer/permeability in patients with HIV disease.
 DT    9601
 AU    O'Doherty MJ; St Thomas' Hospital, London, UK.
 SO    Q J Nucl Med. 1995 Sep;39(3):231-42. Unique Identifier : AIDSLINE
       MED/96033592
 AB    Lung 99mTc DTPA transfer/permeability has been widely used to assess the
       integrity of the lung alveolar-capillary interface. The use in HIV
       positive patients to provide a rapid assessment of causes of
       breathlessness or fever is discussed in this overview. There is I
       believe a clear role for this technique in this group of patients. It is
       more sensitive than Gallium-67 scanning in defining lung disease and is
       capable of distinguishing between alveolitic processes and bacterial
       infections of Kaposi sarcomatous infiltration. The 99mTc DTPA
       transfer/permeability can also define the absence of lung involvement in
       those patients with a fever to allow more suitable investigation to
       proceed. The 99mTc DTPA transfer/permeability measurement is a rapid,
       easy method of evaluating patients with HIV disease. Depending on the
       clinicians philosophy it can be used as a basis to initiate treatment or
       at the very least point to the next necessary investigation.
 DE    *Blood-Air Barrier  Human  HIV
       Infections/COMPLICATIONS/*PHYSIOPATHOLOGY/RADIONUCLIDE  IMAGING  HIV
       Seropositivity/PHYSIOPATHOLOGY/RADIONUCLIDE IMAGING  Lung/*RADIONUCLIDE
       IMAGING  Lung Diseases/COMPLICATIONS/RADIONUCLIDE IMAGING  Permeability
       Technetium Tc 99m Pentetate/*DIAGNOSTIC USE  JOURNAL ARTICLE  REVIEW
       REVIEW, ACADEMIC

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

