       Document 0563
 DOCN  M9610563
 TI    [Clinical course of a HIV-seropositive patient with thrombocytopenia and
       hypergammaglobulinemia who was initially screened by annual complete
       physical examination]
 DT    9601
 AU    Kanai E; Miyazawa K; Kuwabara S; Yoshikawa O; Toyama K; Oshimi K; First
       Department of Internal Medicine, Tokyo Medical College.
 SO    Nihon Rinsho Meneki Gakkai Kaishi. 1995 Feb;18(1):110-5. Unique
       Identifier : AIDSLINE MED/96058426
 AB    A 57-year-old man was admitted because of hypergammaglobulinemia which
       was initially pointed out by annual complete physical examination. No
       significant abnormal findings were observed except polyclonal
       hypergammaglobulinemia at that time (IgG; 2,662 mg/dl, IgA; 422 mg/dl).
       Seven months later, he has progressed to show thrombocytopenia. The
       laboratory data showing the reduction of peripheral CD 4-positive T
       cells (CD 4; 0.2 x 10(9)/l, CD 4/8 ratio; 0.19) and positive serum HIV
       antibody revealed that his hypergammaglobulinemia and thrombocytopenia
       were resulted from HIV infection. The peripheral platelet count
       decreased to 28 x 10(9)/l at minimal point, however, it recovered to 160
       x 10(9)/l within 7 months without treatment. His good performance status
       has been still maintained over 4 years. His whole clinical course
       suggests that there is no significant correlation between peripheral
       platelet counts, serum gammaglobulin levels or the amounts of PAIgG in
       this case. This case proposes that we should also consider a possibility
       of HIV infection for the patients showing hypergammaglobulinemia.
 DE    Case Report  English Abstract  Human
       Hypergammaglobulinemia/DIAGNOSIS/*ETIOLOGY  HIV
       Seropositivity/*COMPLICATIONS  HIV-1/*IMMUNOLOGY  IgA/ANALYSIS
       IgG/ANALYSIS  Male  Middle Age  *Multiphasic Screening  Physical
       Examination  Thrombocytopenia/DIAGNOSIS/*ETIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

