       Document 0562
 DOCN  M9610562
 TI    [Detection of soluble interleukin-2 receptor in idiopathic
       thrombocytopenic purpura]
 DT    9601
 AU    Nomura S; Suzuki M; Miyake T; Miyazaki Y; Kido H; Kagawa H; Yanabu M;
       Fukuhara S; First Department of Internal Medicine, Kansai Medical
       University.
 SO    Nihon Rinsho Meneki Gakkai Kaishi. 1995 Feb;18(1):14-9. Unique
       Identifier : AIDSLINE MED/96058413
 AB    We measured soluble interleukin-2 receptor (sIL-2 R) in serum samples
       from 57 patients with idiopathic thrombocytopenic purpura (ITP). The
       sIL-2 R level was significantly increased in the ITP patients (481.3 +/-
       378.5 U/ml) compared with controls (176.2 +/- 66.9 U/ml) (p < 0.001),
       and was significantly higher in 8 patients positive for hepatitis C
       virus (HCV) antibody positive (1,140.7 +/- 194.3 U/ml) than in 49
       HCV-antibody negative patients (378.9 +/- 278.6 U/ml) (p < 0.0001).
       There was also a significant difference between the HCV-antibody
       negative ITP patients and the controls (p < 0.01). Elevated sIL-2 R
       levels correlated with the CD 4/8 ratio (p < 0.05), but not with the
       platelet count or the level of platelet-associated IgG. The increase of
       sIL-2 R in ITP may be related to the immunological abnormalities
       underlying this disease.
 DE    Adult  Aged  CD4-CD8 Ratio  English Abstract  Female  Hepatitis C
       Antibodies/BLOOD  Human  IgG/BLOOD  Male  Middle Age  Purpura,
       Thrombocytopenic, Idiopathic/*IMMUNOLOGY  Receptors,
       Interleukin-2/*ANALYSIS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

