       Document 0561
 DOCN  M9610561
 TI    [Immunohistochemical study of collagen in gastric cancer tissue]
 DT    9601
 AU    Kondou S; Kanayama K; Morise K; First Department of Internal Medicine,
       Nagoya University School; of Medicine.
 SO    Nihon Rinsho Meneki Gakkai Kaishi. 1995 Apr;18(2):168-77. Unique
       Identifier : AIDSLINE MED/96058434
 AB    The distribution and localization of collagen types were studied
       immunohistochemically in resected tissues obtained from gastric cancer
       patients. The expression of transforming growth factor (TGF) -alpha,
       TGF-beta 1 and TGF-beta 2 on cancer cells as well as the aggregation of
       T lymphocytes in the cancer tissue were also studied, in order to
       determine the differences between differentiated and undifferentiated
       type cancer. The interstitial tissues of differentiated type cancer
       showed intense staining for types I and III collagen, while those of
       undifferentiated type cancer showed intense staining for types I and III
       collagen, in addition to the stronger staining for types IV, V and VI
       collagen. Characteristically, type IV collagen was intensely stained in
       the interstitium in 18 of 20 undifferentiated type cancer (90%), but was
       stained in only one of 15 differentiated type cancer (6%). CD 3+ T
       lymphocytes were aggregated in the interstitial tissue of both the
       tumors, where the density of CD 4+ cells and the ratio of CD 4 to CD 8
       were significantly higher in undifferentiated type cancer than in
       differentiated type cancer. TGF-alpha was detected in cancer cells in
       80% of the differentiated cases and in 45% of the undifferentiated
       cases. The staining of TGF-beta 1 was also detected in 80% of the
       undifferentiated cases, which was significantly higher than 47% in
       differentiated cases. There were no differences in the incidences of
       staining for TGF-beta 2 between differentiated (33%) and
       undifferentiated type cancer (40%). These results suggest that there
       exist different mechanisms in the regulation of collagen production
       between differentiated and undifferentiated types of gastric cancer.
 DE    Adenocarcinoma/*CHEMISTRY/IMMUNOLOGY  Aged  Collagen/*ANALYSIS  CD4-CD8
       Ratio  English Abstract  Female  Human  Immunohistochemistry  Male
       Stomach Neoplasms/*CHEMISTRY/IMMUNOLOGY  Transforming Growth Factor
       alpha/ANALYSIS  Transforming Growth Factor beta/ANALYSIS  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

