       Document 0560
 DOCN  M9610560
 TI    [Chronic cytomegalovirus infection that present specific clinical
       course--a case of a boy with common variable immunodeficiency]
 DT    9601
 AU    Wada Y; Sato T; Kitajima H; Kubo M; Department of Pediatrics, Kashiwa
       Hospital, Tokyo Jikei; University School of Medicine.
 SO    Nihon Rinsho Meneki Gakkai Kaishi. 1995 Apr;18(2):247-55. Unique
       Identifier : AIDSLINE MED/96058444
 AB    We describe an 8-year-old boy with CVID and chronic CMV infection.
       Although at onset he was diagnosed as IgA deficiency, 4 years after his
       clinical manifestations because compatible to CVID. During his clinical
       course he had suffered from various disorders as follows; AIHA,
       interstitial pneumonia, hemophagocytic syndrome, chronic
       gastroenterocolitis and so forth. At the age of 8 the PCR of CMV-DNA of
       biopsy specimen from colon, lung and bone marrow were confirmed to be
       positive. Hematological examinations revealed abnormal cellular immunity
       such as decreased CD 4/8 ratio with increased HLA- DR+ CD 8+ T cell,
       decrease of absolute blood lymphocytes count and reduced response of
       lymphocytes to blastogenetic agents. These findings brought us to
       diagnose him as having CVID complicated with chronic CMV infection. This
       case gives us some impact to speculate what role CMV infection plays in
       CVID, Whose etiology is unknown.
 DE    Anemia, Hemolytic, Autoimmune/ETIOLOGY  Case Report  Child  Chronic
       Disease  Common Variable Immunodeficiency/*COMPLICATIONS/IMMUNOLOGY
       Cytomegalovirus Infections/*ETIOLOGY  CD4-CD8 Ratio  English Abstract
       Histiocytosis, Non-Langerhans-Cell/ETIOLOGY  Human  Lung Diseases,
       Interstitial/ETIOLOGY  Male  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

