       Document 0554
 DOCN  M9610554
 TI    Examination of variables affecting syncytium formation by, and serum
       neutralization of, feline immunodeficiency virus on CrFK cells.
 DT    9601
 AU    Bandecchi P; Pistello M; Matteucci D; Lombardi S; Bendinelli M; Tozzini
       F; Department of Animal Pathology, University of Pisa, Italy.
 SO    New Microbiol. 1995 Jul;18(3):241-52. Unique Identifier : AIDSLINE
       MED/96028320
 AB    The feline immunodeficiency virus (FIV) induces syncytia in Crandell
       feline kidney (CrFK) cells grown in low fetal bovine serum-containing
       medium. This finding has allowed the development of sensitive FIV
       titration and neutralization assays using syncytium formation as an
       indicator of infection. In this report we examine several variables that
       can influence number and size of syncytia. In addition, by performing
       assays under rigidly controlled culture conditions, we confirm that
       serum neutralization assays based on FIV-induced syncytium formation in
       CrFK cells detect broadly reactive neutralizing antibodies.
 DE    Animal  Antibodies, Viral/*IMMUNOLOGY  Carbon Dioxide/PHARMACOLOGY  Cats
       Cell Line  Culture Media  Giant Cells/*METABOLISM/PATHOLOGY/VIROLOGY
       Hydrogen-Ion Concentration  Immune Sera/IMMUNOLOGY  Immunodeficiency
       Virus, Feline/*GROWTH & DEVELOPMENT/GENETICS/  IMMUNOLOGY
       Neutralization Tests/*METHODS  Polymerase Chain Reaction  Sodium
       Bicarbonate/PHARMACOLOGY  Support, Non-U.S. Gov't  Time Factors  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

